COMPARATIVE ANALYSIS OF APPROACHES TO PHARMACOTHERAPY FOR THE TREATMENT OF EPILEPSY IN UKRAINE AND THE UNITED KINGDOM

Abstract

The aim of the work. To carry out a comparative analysis of the range of medicines used for the treatment of epilepsy in accordance with the provisions of regulatory documents in Ukraine and the United Kingdom.

Materials and Methods. The study used official data on the regulatory regulation of epilepsy pharmacotherapy, in particular, the recommendation of the British National Form (updated April 2018), the State Medicines Form (Issue 11, Ministry of Health, Order No. 892 of 18.04.2019), Unified Clinical protocol of primary, emergency, secondary (specialized) and tertiary (highly specialized) medical care for epilepsy in adults ”(Order of the Ministry of Health of Ukraine of April 27, 2014 No. 276). The following methods were used: logical, system-analytical, comparative analysis and generalization of information.

Results and Discussion. According to the results of the analysis of the data of the British National Form, it is determined that 19 anti-epileptic drugs under the international non-proprietary name are recommended for the treatment of epilepsy patients. When comparing antieptic drugs with drugs that are included in the domestic regulatory provisions governing the provision of quality medical and pharmaceutical care to patients, a number of differences were identified. These differences include both the absence of certain medicines under the international non-proprietary name and different approaches to the formation of patients' pharmacotherapy lines. According to the results of a comparative analysis of the composition of the range of recommended anti-epileptic drugs, the British National Form with the State Form of Medicines found that only nine drugs of international non-proprietary name were included in the national composition. Studies of anti-epileptic drugs, according to the State Medicines Form, give grounds for claiming the dominance of foreign-made drugs (68 % of the total number of anti-epileptic drugs presented). Manufacturers of anti-epileptic drugs have been analyzed, leaders in foreign and domestic companies have been established.

Conclusions. A number of differences have been identified between the recommendations of the British National Form and the National Medicines Form and the standardized clinical protocol for the treatment of epilepsy patients. Thus, there are only 9 antiepileptic drugs in the National Medicines Form, out of the 19 medicines listed in the British National Form. The national protocol of treatment includes 12 drugs under the international non-proprietary name. Analysis of the data of the State form of medicines for anti-epileptic drugs, showed that the total number of medicines represented was 315 trade names, taking into account the forms of issue, the main share of this range was formed by drugs of foreign companies, the ratio was 68 % to 32 %.