INFLUENCE OF VAGINAL SUPPOSITORIES OF "KLIMEDEKS" ON THE STATE OF THE SYSTEM OF LPO-AOS ON THE MODEL OF NONSPECIFIC VAGINITIS IN RATS
DOI:
https://doi.org/10.11603/2312-0967.2019.4.10686Keywords:
suppositories, experimental vaginitis, rats, lipid peroxidation, antioxidant systemAbstract
The aim of the work. Investigation of the influence of new vaginal suppositories "Klimedeks" on the indicators of LPO-AOS on the model of nonspecific vaginitis in rats.
Materials and Methods. Nonspecific vaginitis was modeled by a single intravaginal application a mixture of turpentine and dimethyl sulfoxide to non-linear female rats. The activity of the components of the system of LPO-AOS was determined in blood serum and vaginal tissues homogenate. Level of TBA-AP, activity of CAT and SOD were determined in blood serum, and activity of CAT, levels of TBA-AP and G-SH were determined in vaginal tissue. As reference drug there were taken vaginal tablets "Micogynax" and "Suppositories with hippophaes oleum" recommended for the treatment of nonspecific vaginitis.
Results and Discussion. The study found that the suppositories "Klimedeks" showed an antioxidant effect on the model of non-specific (irritative) vaginitis in rats. A significant decrease in the level of TBA-AP, an increase in the activity of CAT in the blood serum and in the vaginal homogenate, a restoration of the level of G-SH in the vaginal homogenate, as well as the activity of SOD in the blood serum of rats with non-specific experimental vaginitis were observed as a result of the influence of the studied suppositories "Klimedeks". Suppositories "Klimedeks" are not inferior to the reference drugs "Micogynax" and "Suppositories with hippophaes oleum" in the activity to reduce the level of TBA-AP, to restore the level of G-SH, the activity of CAT and significantly surpassed the reference drug"Suppositories with hippophaes oleum" in the ability to restore the activity of SOD. This indicates a positive effect of the studied suppositories on the state of the prooxidant-antioxidant system, both locally and systemically, which is positive in the treatment of nonspecific vaginitis and will inhibit the development of systemic complications.
Conclusions. The results of the experiment allow us to recommend the suppositories "Klimedeks" for further study as a drug for the treatment of nonspecific vaginitis.
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