RESEARCH OF THE PRESERVATIVES’ ANTIMICROBIC ACTIVITY FOR THE DEVELOPMENT OF A NEW COMBINED GEL COMPOSITION FOR THE LOCAL TREATMENT OF BURNS
DOI:
https://doi.org/10.11603/2312-0967.2019.3.10409Keywords:
gel, burns, preservatives, antimicrobial activity, microbiological studiesAbstract
The aim of the work. Investigation of the preservatives antimicrobial activity in the gel samples based on water extraction from xenoderm and with lidocaine hydrochloride for topical treatment of burns.
Materials and methods. The study used the method of evaluating the effectiveness of antimicrobial preservatives in accordance with the requirements of the State Pharmacopoeia of Ukraine. The following microorganisms were used as test cultures: Staphylococcus аureus АТСС 25923, Escherichia сoli 055К59 №3912/41, Pseudomonas aeruginosa АТСС 2853 (F51), Candida albicans АТСС 885-653, Aspergіllus brasіlіensіs АТСС 16404.
Results and Discussion. As a result of the conducted research, the effectiveness of the investigated antimicrobial preservatives (nipagine/nipazole, cosgard, phenylethyl alcohol, benzalkonium chloride) of different concentrations in the gel samples based on water extraction from xenoderm and with lidocaine hydrochloride was established. The tested gel samples meet the requirements of the State Pharmacopoeia of Ukraine (second edition, volume 1, section 5.1.3) for the indicator “Antimicrobial preservative efficacy” for medicinal products for external use.
Conclusion. As a result of the conducted research, the most suitable preservative was selected phenylethyl alcohol at a concentration of 0.4%, which is due to its high antimicrobial activity in this pharmaceutical composition, physiological safety, economy, and the possibility of its use as a flavoring.
References
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