RESEARCH OF THE PRESERVATIVES’ ANTIMICROBIC ACTIVITY FOR THE DEVELOPMENT OF A NEW COMBINED GEL COMPOSITION FOR THE LOCAL TREATMENT OF BURNS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.3.10409

Keywords:

gel, burns, preservatives, antimicrobial activity, microbiological studies

Abstract

The aim of the work. Investigation of the preservatives antimicrobial activity in the gel samples based on water extraction from xenoderm and with lidocaine hydrochloride for topical treatment of burns.

Materials and methods. The study used the method of evaluating the effectiveness of antimicrobial preservatives in accordance with the requirements of the State Pharmacopoeia of Ukraine. The following microorganisms were used as test cultures: Staphylococcus аureus АТСС 25923, Escherichia сoli 055К59 №3912/41, Pseudomonas aeruginosa АТСС 2853 (F51), Candida albicans АТСС 885-653, Aspergіllus brasіlіensіs АТСС 16404.

Results and Discussion. As a result of the conducted research, the effectiveness of the investigated antimicrobial preservatives (nipagine/nipazole, cosgard, phenylethyl alcohol, benzalkonium chloride) of different concentrations in the gel samples based on water extraction from xenoderm and with lidocaine hydrochloride was established. The tested gel samples meet the requirements of the State Pharmacopoeia of Ukraine (second edition, volume 1, section 5.1.3) for the indicator “Antimicrobial preservative efficacy” for medicinal products for external use.

Conclusion. As a result of the conducted research, the most suitable preservative was selected phenylethyl alcohol at a concentration of 0.4%, which is due to its high antimicrobial activity in this pharmaceutical composition, physiological safety, economy, and the possibility of its use as a flavoring.

Author Biographies

B. V. Pavliuk, I. Horbachevsky Ternopil National Medical University

PhD-student, Department of Pharmacy Management, Economics and Technology

O. Ya. Lukashiv, SE “Ternopil Scientific and Production Center for Standardization, Metrology and Certification”

PhD (Biology), engineer at testing laboratory

O. V. Pokryshko, I. Horbachevsky Ternopil National Medical University

MD, PhD (Medicine), Associate Professor, Department of Microbiology, Virology and Immunology

M. B. Chubka, I. Horbachevsky Ternopil National Medical University

PhD (Pharmacy), Associate Professor, Pharmacy Department of Educational Scientifiс Institute of Postgraduate Education

T. A. Hroshovyi, I. Horbachevsky Ternopil National Medical University

DS (Pharmacy), Professor, Head of the Department of Pharmacy Management, Economics and Technology

References

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Noronha C, Almeida A. Local burn treatment – topical antimicrobial agents. Annals of Burns and fire disasters. 2000;XIII(4). Available from: http://www.medbc.com/annals/review/vol_13/num_4/text/vol13n4p216.htm

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The effectiveness of antimicrobial preservatives / State Pharmacopoeia of Ukraine in 3 vol., 2nd edition. [Державна Фармакопея України: в 3 т.] Kharkiv: State Enterprise “Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines”; 2015;1:773-5. Ukrainian.

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Published

2019-09-09

How to Cite

Pavliuk, B. V., Lukashiv, O. Y., Pokryshko, O. V., Chubka, M. B., & Hroshovyi, T. A. (2019). RESEARCH OF THE PRESERVATIVES’ ANTIMICROBIC ACTIVITY FOR THE DEVELOPMENT OF A NEW COMBINED GEL COMPOSITION FOR THE LOCAL TREATMENT OF BURNS. Pharmaceutical Review Farmacevtičnij časopis, (3), 35–42. https://doi.org/10.11603/2312-0967.2019.3.10409

Issue

No. 3 (2019)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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