PROBIOTICS FROM THE POSITION OF EVIDENCE-BASED MEDICINE
DOI:
https://doi.org/10.11603/2312-0967.2019.3.10391Keywords:
probiotics, evidence-based medicine, the Cochrane library, systematic reviewsAbstract
The aim of the work. To systematize the data of evidence-based medicine about probiotics, taking into account the degree of confirmation of their effectiveness in the prevention and treatment of various diseases.
Materials and methods. The research material was systematic reviews of the Cochrane library for the period from 2006 to 2018, methods used: information search, analysis and generalization.
Results and discussion. Systematic reviews of the effectiveness and safety of using probiotics have been ranked by date and topic. It has been shown that the relevance of studying the effectiveness of probiotics is increasing. It has been established that the largest share of systematic reviews is devoted to the use of probiotics in gastroenterology.
The safety of probiotic therapy has been confirmed and it has been determined that in order to achieve an effect similar to the one obtained in randomized clinical trials, the same form and dose of a probiotic as in the study should be used. The positive effect of probiotics observed in patients of one age is not extrapolated to patients of other age, and the effect of a certain probiotic is not transferred to other species and strains of probiotic microorganisms.
Conclusions. Based on the analysis of the data of the Cochrane library, 32 systematic reviews of the effectiveness and safety of the use of probiotics have been identified, which are divided into four groups: with verified efficacy; with proven efficacy requiring additional randomized clinical trials; with insufficient evidence of efficacy, but with the prospect of further randomized clinical trials; with unverified efficacy. According to the systematic reviews of the first group, it has been established that the clinically justified direction of the use of probiotics is the prevention of antibiotic-associated diarrhea and the treatment of acute infectious diarrhea.
References
Kalinichenko SV,. Korotkykh OO, Tishchenko IYu. [Contemporary directions of creation and improvement of probiotics]. Ukrayinskyy biofarmatsevtychnyi zhurnal. [Internet]. 2016;1(42). Available from: http://dspace.nuph.edu.ua/bitstream/123456789/8824/1/04-10.pdf
Besh LV. [The problem of intestinal dysbacteriosis in the practice of child allergist: controversial questions and the possibilities of their solutions]. Zdorov`ya dytyny. [Internet]. 2012;7 (42). Available from: http://www.mif-ua.com/archive/article/34947.
Marushko YuV, Asonov АО. [Evidence based for the use of specific probiotics for antibiotic-associated diarrhea in children]. Zdorov`ya dytyny. [Internet]. 2018;5. Available from: http://www.mif-ua.com/archive/article/46432.
Сochrane [Internet]. Available from: http://www.cochrane.org/search/site/probiotics.
Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database of Syst. Rev. [Internet]. 2015 Dec (12). Available from: https://www.cochrane.org/CD004827/IBD_probiotics-prevention-antibiotic-associated-diarrhea-children DOI: 10.1002/14651858. DOI: https://doi.org/10.1002/14651858
Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhea. Cochrane Database of Syst. Rev. [Internet]. 2010 (11). Available from: https://www.cochrane.org/CD003048/INFECTN_probiotics-treating-acute-infectious-diarrhoea DOI: 10.1002/14651858.CD003048.pub3. DOI: https://doi.org/10.1002/14651858.CD003048.pub3
Goldenberg JZ, Yap C, Lytvyn L, Lo CK, Beardsley J, Mertz D, Johnston BS. The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use. Cochrane Database of Syst. Rev. [Internet]. 2017 (12). Available from: https://www. ncbi.nlm.nih.gov/pubmed/23728658 DOI: 10.1002/14651858.CD006095.pub4. DOI: https://doi.org/10.1002/14651858.CD006095.pub4
AlFaleh K, Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database of Syst. Rev. [Internet]. 2014 (4). Available from: https://www.cochrane.org/CD005496/NEONATAL_probiotics-for-prevention-of-necrotizing-enterocolitis-in-preterm-infants DOI: 10.1002/14651858.CD005496.pub4. DOI: https://doi.org/10.1002/14651858.CD005496.pub4
Othman M, Alfirevic Z, Neilson JP. Probiotics for preventing preterm labour. Cochrane Database of Syst. Rev. [Internet]. 2007 (1). Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005941.pub2/full?highlightAbstract=prevent%7Cpreventing%7Cprobiot%7Cfour%7Cpreterm%7Cfor%7Clabour%7Cprobiotics%7Clabor DOI: 10.1002/14651858.CD005941.pub2. DOI: https://doi.org/10.1002/14651858.CD005941.pub2
Senok AC, Verstraelen H, Temmerman M, Botta GA. Probiotics for thetreatment of bacterial vaginosis. Cochrane Data base of Syst.Rev. [Internet]. 2009 (4). Available from: https://www.cochrane.org/CD006289/STI_probiotics-for-the-treatment-of-bacterial-vaginosis DOI: 10.1002/14651858.CD006289.pub2. DOI: https://doi.org/10.1002/14651858.CD006289.pub2
Xie H, Feng D, Wei D, Mei L, Chen H, Wang X, Fang F. Probiotics for vulvovaginal candidiasis in non-pregnant women. Cochrane Database of Syst. Rev. [Internet]. 2017 (11). Available from: https://www.cochrane.org/CD010496/STI_probiotics-vulvovaginal-candidiasis-non-pregnant-women DOI: 10.1002/14651858.CD010496.pub2. DOI: https://doi.org/10.1002/14651858.CD010496.pub2
Newlove-Delgado TV, Martin AE, Abbott RA, Bethel A, Thompson-Coon J, Whear R, Logan S. Dietary interventions for recurrent abdominal pain in childhood. Cochrane Database of Syst. Rev. [Internet]. 2017 (3). Available from: https://www.cochrane.org/CD010972/BEHAV_dietary-interventions-recurrent-abdominal-pain-children DOI: 10.1002/14651858.CD010972.pub2. DOI: https://doi.org/10.1002/14651858.CD010972.pub2
Hao Q, Dong B, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database of Syst. Rev. [Internet]. 2015 (2). Available from: https://www.cochrane.org/CD006895/ARI_probiotics-live-micro-organisms-to-prevent-upper-respiratory-tract-infections-urtis-for-example-the-common-cold DOI: 10.1002/14651858.CD006895.pub3. DOI: https://doi.org/10.1002/14651858.CD006895.pub3
Schwenger EM, Tejani AM, Loewen PS. Probiotics for preventing urinary tract infections in adults and children. Cochrane Database of Syst. Rev. [Internet]. 2015 (12). Available from: http://www.cochrane.org/CD008772/RENAL_probiotics-preventing-urinary-tract-infections-adults-and-children DOI: 10.1002/14651858.CD008772.pub2. DOI: https://doi.org/10.1002/14651858.CD008772.pub2
Barrett HL, Dekker Nitert M, Conwell LS, Callaway LK. Probiotics for preventing gestational diabetes. Cochrane Database of Syst. Rev. [Internet]. 2014 (2). Available from: http://www.cochrane.org/CD009951/PREG_probiotics-to-prevent-gestational-diabetes-mellitus DOI: 10.1002/14651858.CD009951.pub2. DOI: https://doi.org/10.1002/14651858.CD009951.pub2
Bo L, Li J, Tao T, Bai Y, Ye X, Hotchkiss RS, Kollef MH, Crooks NH, Deng X. Probiotics for preventing ventilator-associated pneumonia. Cochrane Database of Syst.Rev. [Internet]. 2014 (10). Available from: http://www.cochrane.org/CD009066/ARI_probiotics-for-preventing-ventilator-associated-pneumonia DOI: 10.1002/14651858.CD009066.pub2. DOI: https://doi.org/10.1002/14651858.CD009066.pub2
Dalal R, McGee RG, Riordan SM, Webster AC. Probiotics for people with hepatic encephalopathy. Cochrane Database of Syst. Rev. [Internet]. 2017 (2). Available from: http://www.cochrane.org/CD008716/LIVER_probiotics-people-hepatic-encephalopathy DOI:10.1002/14651858.CD008716.pub3. DOI: https://doi.org/10.1002/14651858.CD008716.pub3
Wei D, Heus P, van de Wetering FT, van Tienhoven G, Verleye L, Scholten RJPM. Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer. Cochrane Database of Sys. Rev. [Internet]. 2018 (8). Available from: https://www.cochrane.org/CD008831/GYNAECA_live-micro-organisms-prevention-or-treatment-diarrhoea-people-cancer-who-are-treated-chemotherapy-or DOI: 10.1002/14651858.CD008831.pub3. DOI: https://doi.org/10.1002/14651858.CD008831.pub3
Bernaola Aponte G, Bada Mancilla C, Carreazo N, Rojas Galarza R. Probiotics for treating persistent diarrhoea in children. Cochrane Database of Syst. Rev. [Internet]. 2013 (8). Available from: http://www.cochrane.org/CD007401/INFECTN_probiotics-for-persistent-diarrhoea-in-children DOI: 10.1002/14651858.CD007401.pub3. DOI: https://doi.org/10.1002/14651858.CD007401.pub3
Mallon PT, McKay D, Kirk SJ, Gardiner K. Probiotics for the treatment of active ulcerative colitis. Cochrane Database of Syst. Rev. [Internet]. 2007 (4). Available from: https://www.cochrane.org/CD005573/IBD_probiotics-for-the-treatment-of-active-ulcerative-colitis DOI: 10.1002/14651858.CD005573.pub2. DOI: https://doi.org/10.1002/14651858.CD005573.pub2
Makrgeorgou A, Leonardi-Bee J, Bath-Hextall FJ, Murrell DF, Tang MLK, Roberts A, Boyle RJ. Probiotics for treating eczema. Cochrane Database of Syst.Rev. [Internet]. 2018 (11). Available from: http://www.cochrane.org/CD006135/SKIN_probiotics-for-treating-eczema DOI: 10.1002/14651858.CD006135.pub3. DOI: https://doi.org/10.1002/14651858.CD006135.pub3
Naidoo K, Gordon M, Fagbemi AO, Thomas AG, Akobeng AK. Probiotics for maintenance of remission in ulcerative colitis. Cochrane Database of Syst.Rev. [Internet]. 2011 (12). Available from: https://www.cochrane.org/CD007443/IBD_probiotics-for-maintenance-of-remission-in-ulcerative-colitis DOI: 10.1002/14651858.CD007443.pub2. DOI: https://doi.org/10.1002/14651858.CD007443.pub2
Singh S, Stroud AM, Holubar SD, Sandborn WJ, Pardi D. Therapy for treatment and prevention of pouchitis. Cochrane Database Syst. Rev. [Internet]. 2015 (11). Available from: https://www.cochrane.org/CD001176/IBD_ therapy-treatment-and-prevention-pouchitis DOI: 10.1002/14651858.CD001176.pub4. DOI: https://doi.org/10.1002/14651858.CD001176.pub4
Poropat G, Giljaca V, Hauser G, Štimac D. Enteral nutrition formulations for acute pancreatitis. Cochrane Database of Syst. Rev. [Internet]. 2015 (3). Available from: https://www.cochrane.org/CD010605/UPPERGI_tube-feeding-in-patients-with-acute-pancreatitis DOI: 10.1002/14651858.CD010605.pub2. DOI: https://doi.org/10.1002/14651858.CD010605.pub2
Osborn DA, Sinn JKH. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database of Syst. Rev. [Internet]. 2007 (4). Available from: https://www.cochrane.org/CD006475/NEONATAL_probiotics-in-infants-for-prevention-of-allergic-disease-and-food-hypersensitivity DOI: 10.1002/14651858.CD006475.pub2. DOI: https://doi.org/10.1002/14651858.CD006475.pub2
Kafil TS, Nguyen TM, Patton PH, MacDonald JK, Chande N, McDonald J. Interventions for treating collagenous colitis. Cochrane Database of Syst. Rev. [Internet]. 2017 (11). Available from: https://www.cochrane.org/CD003575/IBD_treatments-collagenous-colitis DOI: 10.1002/14651858.CD003575.pub6. DOI: https://doi.org/10.1002/14651858.CD003575.pub6
Rolfe VE, Fortun PJ, Hawkey CJ, Bath-Hextall FJ. Probiotics for maintenance of remission in Crohn's disease. Cochrane Database of Syst. Rev. [Internet]. 2006 (4). Available from: https://www.cochrane.org/CD004826/IBD_probiotics-for-maintenance-of-remission-in-crohns-disease DOI: 10.1002/14651858.CD004826.pub2. DOI: https://doi.org/10.1002/14651858.CD004826.pub2
Butterworth AD, Thomas AG, Akobeng AK. Probiotics for induction of remission in Crohn's disease. Cochrane Database of Syst. Rev. [Internet]. 2008 (3). Available from: https://www.cochrane.org/CD006634/IBD_probiotics-for-treatment-of-active-crohns-disease DOI: 10.1002/14651858.CD006634.pub2. DOI: https://doi.org/10.1002/14651858.CD006634.pub2
Lawrie TA, Green JT, Beresford M, Wedlake L, Burden S, Davidson SE, Lal S, Henson CC, Andreyev HN. Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers // Cochrane Database of Syst. Rev. [Internet]. 2018 (1). Available from: https://www.cochrane.org/CD012529/GYNAECA_interventions-reduce-digestive-side-effects-pelvic-x-ray-treatment DOI: 10.1002/14651858.CD012529.pub2. DOI: https://doi.org/10.1002/14651858.CD012529.pub2
Henson CC, Burden S, Davidson SE, Lal S. Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy // Cochrane Database of Syst. Rev. [Internet]. 2013 (11). Available from: https://www.cochrane.org/CD009896/GYNAECA_do-nutritional-interventions-reduce-gastrointestinal-toxicity-in-adults-undergoing-radical-pelvic-radiotherapy DOI: 10.1002/14651858.CD009896.pub2. DOI: https://doi.org/10.1002/14651858.CD009896.pub2
Gurusamy K, Nagendran M, Davidson BR. Methods of preventing bacterial sepsis and wound complications after liver transplantation. Cochrane Database of Syst. Rev. [Internet]. 2014 (3) Available from: https://www.cochrane.org/CD006660/LIVER_interventions-to-prevent-bacterial-infective-complications-and-wound-complications-in-liver-transplantation DOI: 10.1002/14651858.CD006660.pub3. DOI: https://doi.org/10.1002/14651858.CD006660.pub3
Pillai A, Nelson RL. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database of Syst. Rev. [Internet]. 2008 (1). Available from: https://www.cochrane.org/CD004611/IBD_probiotics-for-treatment-of-clostridium-difficile-associated-colitis-in-adults DOI: 10.1002/14651858.CD004611.pub2. DOI: https://doi.org/10.1002/14651858.CD004611.pub2
Lirussi F, Mastropasqua E, Orando S, Orlando R. Probiotics for non-alcoholic fatty liver disease and/or steatohepatitis // Cochrane Database of Syst. Rev. [Internet]. 2007 (1). Available from: https://www.cochrane.org/CD005165/LIVER_no-evidence-to-support-or-refute-probiotics-for-patients-with-non-alcoholic-fatty-liver-disease-andor-steatohepatitis DOI: 10.1002/14651858.CD005165.pub2. DOI: https://doi.org/10.1002/14651858.CD005165.pub2
Grev J, Berg M, Soll R. Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database of Syst. Rev. [Internet]. 2018 (12). Available from: https://www.cochrane.org/CD012519/NEONATAL_maternal-probiotic-supplementation-prevention-morbidity-and-mortality-preterm-infants DOI: 10.1002/14651858.CD012519.pub2. DOI: https://doi.org/10.1002/14651858.CD012519.pub2
Toh S, Boswell-Ruys CL, Lee BB, Simpson JM, Clezy KR. Probiotics for preventing urinary tract infection in people with neuropathic bladder. Cochrane Database of Syst. Rev. [Internet]. 2017 (9). Available from: https://www.cochrane.org/CD010723/RENAL_probiotics-preventing-urinary-tract-infections-people-bladder-dysfunction-after-nervous-system DOI: 10.1002/14651858.CD010723.pub2. DOI: https://doi.org/10.1002/14651858.CD010723.pub2
Doherty G, Bennett G, Patil S, Cheifetz A, Moss AC. Interventions for prevention of post-operative recurrence of Crohn's disease. Cochrane Database of Syst. Rev. [Internet]. 2009 (4). Available from: https://www.cochrane.org/CD006873/IBD_interventions-for-prevention-of-post-operative-recurrence-of-crohns-disease DOI: 10.1002/14651858.CD006873.pub2. DOI: https://doi.org/10.1002/14651858.CD006873.pub2
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