INVESTIGATION OF THE INFLUENCE OF EXCIPIENTS ON PHARMACO-TECHNOLOGICAL PROPERTIES OF POWDER MASSES WITH PLANT EXTRACTS AND ESSENTIAL OIL

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.2.10248

Keywords:

powder masses, plant extracts, Geranium sibiricum, Geranium sanguineum, pharmaco-technological indicators, mathematical planning

Abstract

The aim of the work. Investigation of the influence of excipients on the pharmaco-technological properties of powder masses with plant extracts and essential oil.

Materials and Methods. The composition of powder masses included active substances such as dry extract of Geranium sanguineum L. herbs, dry extract of Geranium sibiricum L. herbs and essential oil of Salvia sclare in the ratio – 3:1:1,2. 30 excipients were selected for the experiment. They were used to obtain tablets by direct compression. All of them were divided into 6 groups of 5 substances in each. The study of the influence of excipients on the pharmaco-technological properties of powder masses was carried out by determining the bulk density, density after shrinkage, flowability, the angle of natural slope (SPF 2 edition).

Results and Discussion. The results of the dispersion analysis of experimental data showed that the highest value of the free bulk density of powder masses with plant extracts and essential oil was obtained using basic magnesium carbonate, microcrystalline cellulose (MCC) burst, sodium starch glycolate, ludipress, perlitol 500 DC, compactrol and sodium lauryl sulfate. At presence in the powder masses neusilin UFL 2, MCC burst, sodium starch glycolate, ludipress, MagGran and stearate acid the best indexes of density after shrinkage were obtained.

Basic magnesium carbonate, MCC burst, sodium carboxymethyl starch, ludipress, emcompress and calcium stearate is most positively affected on the flowability of powder masses.

The smallest value of the angle of natural slope of powder masses was obtained with the use of neusilin UFL 2, microcelac 100, MCC burst, pregelatinized starch, calcium hydrogen phosphate anhydrous and stearic acid.

Conclusions. The conducted studies allowed to determine the influence of 30 excipients on the basic pharmaco-technological parameters of powder masses with dry extracts herbs of Geranium sanguineum L. and Geranium sibiricum L., as well as essential oil of Salvia sclare.

Author Biographies

O. I. Hordiienko, I. Horbachevsky Ternopil National Medical University

teacher of pharmaceutical disciplines, Chortkiv State Medical College; PhD student of the Department of Pharmacy Management, Economics and Technology

Т. А. Hroshovyi , I. Horbachevsky Ternopil National Medical University

DS (Рharmacy), Professor, Chief of the Department of Pharmacy Management, Economics and Technology

References

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Hordiienko OI, Hroshovyy TA, Klymnyuk SI, Pokryshko OV, Benzel IL, Benzel LV , inventors; I. Horbachevsky Ternopil National Medical University, assignee. Pharmaceutical composition with antimicrobial, antifungal and anti-inflammatory action on the basis of plant extracts and essential oil [Фармацевтична композиція з антимікробною, протигрибковою і протизапальною дією на основі рослинних екстрактів та ефірної олії]. UA 2018 07941 (Patent) 2019 Jan 10. Ukrainian.

State Pharmacopoeia of Ukraine. [Державна Фармакопея України: в 3 т.,2e вид.] Kharkiv: Derzhavne pidpryiemstvo “Naukovoekspertnyi farmakopeinyi tsentr”; 2015. Ukrainian.

Ruban OA, Pertsev IM, Kutsenko SA, Maslii YuS. Substances in the manufacture of drugs: teaching manual for students of higher education [Допоміжні речовини у виробництві ліків: навч. посіб. для студентів вищ. фармац. навч. закл.] Kharkiv: Zoloti storinkн; 2016. Ukrainian.

Hroshovyi TA, Martseniuk VP, Kucherenko LI, Vronska LV, Hurieieva SM. Matematychne planuvannia eksperymentu v farmatsii [Mathematical planning of experiment in pharmacy]. Ternopil: Ternopil State Medical University; 2008. Ukrainian.

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Published

2019-06-23

How to Cite

Hordiienko, O. I. ., & Hroshovyi Т. А. (2019). INVESTIGATION OF THE INFLUENCE OF EXCIPIENTS ON PHARMACO-TECHNOLOGICAL PROPERTIES OF POWDER MASSES WITH PLANT EXTRACTS AND ESSENTIAL OIL. Pharmaceutical Review Farmacevtičnij časopis, (2), 36–42. https://doi.org/10.11603/2312-0967.2019.2.10248

Issue

No. 2 (2019)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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