RHEOLOGICAL STUDIES OF GEL, CONTAINING A WATER EXTRACT WITH A XENODERM, FOR LOCAL TREATMENT ОF BURNS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.2.10199

Keywords:

carbomer, xenoderm, gel, dynamic viscosity, thixotropic properties, stability

Abstract

The aim of the work. Investigation of rheological (thixotropic) properties of the developed gel and determination of temperature influence on its stability.

Materials and Methods. The subject of the study was a gel for local treatment of burns based on a cross-linked copolymer of acrylic acid – a carbomer Carbopol® Ultrez 21 containing a water extract with xenoderm and lidocaine hydrochloride. The rheological properties studied on a rotary viscometer "Rheomat-30". The shear stress, dynamic viscosity and mechanical stability were studied as a characteristic of gel.

Results and Discussion. In order to determine the flow type, the presence of thixotropic properties and the mechanical stability of the gel, the rheogram of its fluidity was investigated. During the experiments, it was found that the gel under investigation is a non-Newtonian fluid and had a plastic type of fluidity that characterizes it as a structured disperse system. The presence of thixotropic properties in the investigated gel characterizes the satisfactory ability to extrude from tubes and smearing.

Conclusions. Dependence of rheological properties, in particular, structural viscosity of the investigated gel on temperature is determined. Calculated values of the mechanical stability of the gel allow predicting the stability of the drug during its intended shelf life.

Author Biographies

B. V. Vons, I. Horbachevsky Ternopil National Medical University

PhD student, the Pharmacy Management, Economics and Technology Department

Y. Y. Melnyk, Lviv Polytechnic National University

Senior Research Fellow,  the Chemical Technology of Plastics Processing Department

T. A. Hroshovyi, I. Horbachevsky Ternopil National Medical University

DS (Pharmacy), Professor, Head of the Pharmacy Management, Economics and Technology Department

V. Y. Skorokhoda, Lviv Polytechnic National University

DS (Technical), Professor, the Chemical Technology of Plastics Processing Department, Director of the Institute of Chemistry and Chemical Technology

M. B. Chubka, I. Horbachevsky Ternopil National Medical University

PhD, Associate Professor,the Pharmacy Department, Educational Scientifiс Institute of Postgraduate Education

References

Vons ВV, Chubka MB, Hroshovyi TA [The problem of treatment of burns’ wounds and characteristic of drugs for the local treatment of burns]. Aktualni pytannia farmatsevtychnoi i medychnoi nauky ta praktyky. 2018;11(1): 119-25. Available from: DOI: 10.14739/2409-2932.2018.1.123731. Ukrainian.

Powar RS, Sudhir BM, Prabhu MD, Rajput DU, Mallapur BN. Epidemiological study of pediatric burns at a tertiary care centre in South India. Int J Community Med Public Health. 2016;3: 1242-6. Available from: http://dx.doi.org/10.18203/2394-6040.ijcmph20161392. DOI: https://doi.org/10.18203/2394-6040.ijcmph20161392

Vons BV, Chubka MB, Groshovyi TA. Market analysis of semisolid dosage forms registered in Ukraine and research of excipients included to their formulas. Farmatsevt chasop. 2015;1:55-61. Available from: https://doi.org/10.14739/2409-2932.2018.1.123731. DOI: https://doi.org/10.14739/2409-2932.2018.1.123731

Regulatory documents of the Ministry of Health of Ukraine [Нормативно-директивні документи МОЗ України]. Available from: http://mozdocs.kiev.ua. Ukrainian.

Lyapunov AN,. Bezuglaya EP, Lyapunov NA, Kirilyuk IA [Studying gels with carbomers by the rotational viscometry and spin probe techniques]. J Chem-Pharm. 2015;49(9):51-6. Russian. Available from: https://doi.org/10.30906/0023-1134-2015-49-9-51-56. DOI: https://doi.org/10.30906/0023-1134-2015-49-9-51-56

Carbopol® Ultrez 21Polymer, Technical Data Sheet (TDS-297), Lubrizol, Cleveland (2002). Available from: https://www.ge-iic.com/files/fichas%20productos/Carbopol_Ultrez_21_hoja_tecnica.pdf.

Hladukh IeV, Marcelle Seguy Anael, Nicolaychuk NO. [The rheological studies of the gel base with a dense extract from burdock]. Sotsialna farmatsiia v okhoroni zdorovia. 2017;3(3): 21-6. Available from: https://doi.org/10.24959/sphhcj.17.92. Ukrainian. DOI: https://doi.org/10.24959/sphhcj.17.92

Carvalho FC, Calixto G. Rheological, mechanical and bioadhesive behavior of hydrogels to optimize skin delivery system. Drug. Dev. Ind. Pharm. 2013;39(11): 1750-7. Available from: DOI: 10.3109/03639045.2012.734510. DOI: https://doi.org/10.3109/03639045.2012.734510

State Pharmacopoeia of Ukraine in 3 vol., 2nd edition. [Державна Фармакопея України: в 3 т.] Kharkiv: State Enter prise “Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines”; 2015. Ukrainian.

Davtian LL, Vashchuk VA, Polishchuk YuP. Rheological research process as the basis for creating a new drug. Farmatsevt zhurnal. 2013;4: 52-8. Ukrainian.

Shramm G. Osnovy prakticheskoy reologii i reometrii [Fundamentals of practical rheology and rheometry]. Moscow: Kolos; 2003. Russian.

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Published

2019-06-12

How to Cite

Vons, B. V., Melnyk, Y. Y., Hroshovyi, T. A., Skorokhoda, V. Y., & Chubka, M. B. (2019). RHEOLOGICAL STUDIES OF GEL, CONTAINING A WATER EXTRACT WITH A XENODERM, FOR LOCAL TREATMENT ОF BURNS. Pharmaceutical Review Farmacevtičnij časopis, (2), 30–35. https://doi.org/10.11603/2312-0967.2019.2.10199

Issue

No. 2 (2019)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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