MODERN STATE OF CREATION, PRODUCTION AND RESEARCH OF TABLET DRUGS Part 29. Characteristics of the process of development and research of matrix tablets
DOI:
https://doi.org/10.11603/2312-0967.2019.2.10197Keywords:
matrix tablets, polymers, prolonged releaseAbstract
The aim of the work. Analysis and systematization of the literature data about peculiarities of the creation of various types of matrix tablets, as well as the influence of the factors which regulate the drug release from matrix systems.
Materials and Methods. The methods of information search and data analysis about the medical form matrix tablets were used.
Results and Discussion. The literature data on the requirements for drugs on the basis of which matrix tablets can be formulated are presented. The hydrophobic, hydrophilic, fat-wax, biodegradable types of matrix systems are considered. The examples of technologies, formulations, and methods of analysis of matrix tablets are presented. The influence of the factors which regulate the drug release from matrix systems is analyzed. The examples of drugs as potential candidates for preparing matrix tablets are presented.
Conclusions. Matrix tablets, developed by the rational combination of polymers with other excipients, can be successfully applied for prolonged drug release. The current perspective is the creation of matrix tablets with poorly water soluble drug and provides drug release up to 24 hours.
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