DISTURBANCE OF B-LYMPHOCYTE FUNCTION AT HIV INFECTION

Authors

  • H. O. Revenko State Institution «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»
  • V. V. Mavrutenkov State Institution «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»

DOI:

https://doi.org/10.11603/1681-2727.2017.1.7772

Keywords:

HIV, B-cell, lymphocytes, lymphopenia, immunopathogenesis, apoptosis, ART, vaccination.

Abstract

Aim – on the basis of literary information to analyse the parafunction of B-limphocytes at HIV infection.

HIV causes a chronic infection, which is not destroyed by the immune system of the body. Besides progressive decline and dysfunction of CD4+ T cells, HIV infection leads to intensive phenotypic and functional abnormalities in a pool of B-lymphocytes. Although B cells are not the primary target for HIV, there are enough studies that show significant damage specifically in subpopulation of B lymphocytes.

Conclusions. Besides apparent lymphopenia, which is caused by CD4+ T lymphocytopenia, there are functional disorders, first of all, in populations of B cells, namely hipergammaglobuliemia, polyclonal abnormal activation of B cells, expansion of immature/transitional B cells, induction of terminal differentiation of B cells, increased levels of autoantibodies, abnormal predisposition to apoptosis, increased frequency of B-cell malignancies, as well, which is also quite important, low humoral immune response to vaccine antigens. In addition, HIV infection is associated with a decrease of CD27 memory B cell may not be negated, even with the early appointment of antiretroviral therapy. Both cellular and humoral immunity are not capable of controlling the infection, which leads to a significant depletion of lymphocytes function and increases susceptibility to opportunistic infections. Deeper understanding of the pathogenic mechanisms of B-lymphocyte dysfunction could potentially lead to new strategies for treatment and creating preventive vaccine. This review presents the mechanisms involved in the dysfunction of B cells in HIV infection, which are least studied in the immunopathogenesis of HIV infection.

Author Biographies

H. O. Revenko, State Institution «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»

асистент кафедри інфекційних хвороб ДЗ "Дніпропетровська медична академія МОЗ України"

V. V. Mavrutenkov, State Institution «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»

доктор медичних наук, професор кафедри інфекційних хвороб ДЗ "Дніпропетровська медична академія"

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Published

2017-06-14

How to Cite

Revenko, H. O., & Mavrutenkov, V. V. (2017). DISTURBANCE OF B-LYMPHOCYTE FUNCTION AT HIV INFECTION. Infectious Diseases – Infektsiyni Khvoroby, (1), 50–59. https://doi.org/10.11603/1681-2727.2017.1.7772

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