CHANGES OF CELL IMMUNITY IN HIV-INFECTED WITH CHRONIC KIDNEY DISEASE

Abstract

The aim of the work – to determine the va­lue of immunograms in assessing HIV-infected persons.

Patients and methods. Objective 292 HIV-infected patients, who were on an outpatient screening at the Chernivtsi Regional AIDS Center, were screened.

Results. In HIV-infected persons with chronic kidney disease, deviations from the side have been detected absolute content of T-helper cells, cytotoxic T-cells, as well as immunoregulatory index. At the level of subpopulations of T-lymphocytes sexual differences are manifested. At grouping data on the level of proteinuria to determine population and subpopulations the composition of lymphocytes in the blood were determined by the differences between the total amount lymphocytes, absolute number of T-lymphocytes and cytotoxic T-cells.

Conclusions. The absolute and relative numbers of CD3⁺CD4⁺-cells, immunoregulatory index, and absolute and relative values of cytolytic T-lymphocytes (CD3⁺CD56⁺) in HIV-infected patients with renal impairment were significantly lower in comparison with HIV-infected patients without kidney disease (p<0.05). Thus, it can be argued that kidney damage in people with HIV develops in the context of a more significant drop in the number of predominantly T-helper subpopulations of lymphocytes.

At the level of subpopulations of T-lymphocytes, sexual differences are also manifested: in men, compared to women, a significantly lower percentage of T-helper lymphocytes (CD3⁺CD4⁺), a significantly higher proportion of cytotoxic T cells (CD3⁺CD8⁺) and, correspondingly, a lowering of the immunoregulatory index (in all cases p<0.05).

With an increase in the level of proteinuria in the blood, the absolute number of lymphocytes and T-lymphocytes (CD3⁺) decreases, as well as the percentage and absolute number of cytotoxic T-cells (CD3⁺CD8⁺) increases. However, no correlation analysis of proteinuria and immunohistochemistry rates showed any significant association.