THE EFFICIENCY OF ANTI-VIRUS THERAPY IN RESIDENTS OF TERNOPIL WITH CHRONIC HEPATITIS В AND C USED BY STATE PROGRAM THERAPY
DOI:
https://doi.org/10.11603/1681-2727.2017.4.8421Keywords:
сhronic hepatitis, fibrosis, treatment, interferon, sophosbuvir, tenofovir.Abstract
The issue of parenteral viral hepatitis has focused attention not only on doctors but also on the public due to their very dangerous medical and social consequences over the past decades.
The aim of the study – to describe the effectiveness of modern antiviral therapy (MAT) of HB, H B+C and HC in residents of the Ternopil region, which were treated under the State Program.
Patients and methods. In 2013-2016 due to State Program 79 patients were treated, including chronic hepatitis (CH) C – 47, CHB+C – 3, CHB – 29. Men were 74.7 %, women – 25.3 %. The efficacy of MAT was evaluated according to biochemical, virological, and histological criteria.
Conclusions. The use of sofosbuvir in patients with CHC significantly increases the effectiveness of MAT. MAT of CHB is not sufficient (55.2 %), which needs improvement in future. Eradication of HVC does not guarantee the progression of liver fibrosis.
References
Kabinet Ministriv Ukrayiny (2013). Postanova vid 29.04.2013 № 617 «Derzhavna tsilova sotsialna prohrama profilaktyky, diahnostyky ta likuvannia virusnykh hepatytiv na period do 2016 roku» [«State target social program of prevention, diagnosis and treatment of viral hepatitis for the period till 2016», approved by the decision of the Cabinet of Ministers of Ukraine dated April 29, 2013 № 617]. [in Ukrainian].
MOZ Ukrainy (2005). Nakaz vid 13.06.2005 № 271 «Klinichnyi protokol nadannia medychnoi dopomohy khvorym na khronichni hepatyty» [«Clinical protocol for the provision of medical care to patients with chronic hepatitis», approved by the order of the Ministry of Health of Ukraine dated 13.06.2005 N 271]. [in Ukrainian].
MOZ Ukrainy (2014). Nakaz vid 02.04.2014 № 233 «Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) medychnoi dopomohy doroslym ta ditiam «Virusnyi hepatyt C» [«Unified clinical protocol of primary, secondary (specialized) medical care for adults and children «Viral hepatitis C», approved by the order of the Ministry of Health of Ukraine from 02.04.2014 № 233]. [in Ukrainian].
MOZ Ukrainy (2016). Nakaz vid 21.06.2016 r. № 613. «Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi), tretynnoi (vysokospetsializovanoi) medychnoi dopomohy «Virusnyi hepatyt B u doroslykh» [«Unified clinical protocol of primary, secondary (specialized), tertiary (highly specialized) medical care «Viral hepatitis B in adults», approved by the Order of the Ministry of Health of Ukraine dated June 21, 2016, № 613]. [in Ukrainian].
MOZ Ukrainy (2016). Nakaz vid 18.07.2016 r. № 729 «Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi), tretynnoi (vysokospetsializovanoi) medychnoi dopomohy «Virusnyi hepatyt С u doroslykh» [«Unified clinical protocol of primary, secondary (specialized), tertiary (highly specialized) medical care «Viral hepatitis C in adults», approved by the order of the Ministry of Health of Ukraine dated July 18, 2016, № 729] [in Ukrainian].
EASL (2015). Recommendations on Treatment of Hepatitis C 2015. J. Hepatology, 63, 199-236.
EASL (2017). Recommendations on Treatment of Hepatitis C 2016. J. Hepatology, 66, 153-194.
Ukrainian base of Medical statistic «Zdorovya dlya vsikh» (09.09.2013). http://medstat.gov.ua/ukr/about.html.
El-Serag, H., Kunik, M., Richardson, P., Rabeneck, L. (2002). Psychiatric disorders among veterans with hepatitis С infection. Gastroenterology, 123 (2), 476-482.
Kowala-Piaskowska, A., Figlerowicz, M., Mozer-Lisewska, I. (2007). Early virological response in children with chronic hepatitis C treated with pegulated interferon and ribavirin. Infection, 35, 175-179.
Dubynska, H.M., Koval, T.I., Syzova, L.M., Iziumska, O.M., Bodnar, V.A., Kotelevska, T.M., … & Voloshyna, L.H. (2016). Analiz efektyvnosti protyvirusnoi terapii khronichnoho hepatytu C u patsientiv Poltavskoi oblasti (otrymanoi za rakhunok Derzhavnoi tsilovoi sotsialnoi prohramy profilaktyky, diahnostyky ta likuvannia virusnykh hepatytiv) [Analysis of the effectiveness of antiviral therapy of chronic hepatitis C in patients of the Poltava region (obtained at the expense of the State target social program for the prevention, diagnosis and treatment of viral hepatitis)]. Diahnostyka i terapiia infektsiinykh khvorob na riznykh rivniakh nadannia medychnoi dopomohy: Materialy Vseukr. nauk.-prakt. konf. infektsionistiv i plenumu HO «Vseukrainska asotsiatsiia infektsionistiv» (29-30 veresnia 2016 r., m. Vinnytsia). Ternopil: TDMU, Ukrmedknyha, 60-62. [in Ukrainian].
Downloads
Published
How to Cite
Issue
Section
License
Journal Infectious Disease (Infektsiini Khvoroby) allows the author(s) to hold the copyright without registration
Users can use, reuse and build upon the material published in the journal but only for non-commercial purposes
This journal is available through Creative Commons (CC) License BY-NC "Attribution-NonCommercial" 4.0
