THE COURSE OF COMBINED COEXISTENCE OF TUBERCULOSIS AND LAMBLIOSIS

Authors

  • L. P. Melnyk I. Horbachevsky Ternopil State Medical University
  • L. A. Hryshchuk I. Horbachevsky Ternopil State Medical University
  • N. A. Vasylieva I. Horbachevsky Ternopil State Medical University
  • M. I. Shkilna I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/1681-2727.2017.3.8227

Keywords:

tuberculosis, lambliosis (giardiasis), combined course.

Abstract

Despite of the being taken anti-TB measures, the prevalence of tuberculosis in Ukraine still remains high, especially in regions that are endemic to parasitic infections.

The aim of the study – to identify the prevalence of lambliosis (giardiasis) among patients with tuberculosis.

Patients and methods. Under the supervision were 82 patients with tuberculosis (TB) treated at the Ternopil Regional TB Dispensary during 2016–2017. Men (79.3 %) and the inhabitants of the village (73.2 %) dominated.

In all patients the diagnosis of TB was confirmed bacteriologically or by DNA detection (PCR), in 2 patients with breast tuberculosis and TB meningitis − histologically. Liamblia intestinalis were detected by stool microscopy.

Conclusions. Accompanying lambliosis is probably one of the aggravating factors in the course of tuberculosis. Elimination of invasion in patients with tuberculosis may also allow the adjusting of development of adverse reactions to anti-tuberculosis drugs.

References

Tuberkuloz v Ukraini: Analitychno-statystychnyi dovidnyk [Tuberculosis in Ukraine: Analytical and statistical guide]. (2016) [in Ukrainian].

Kramariev S.O., Yershova I.B., & Mochalova H.O. (2012). Problemy diahnostyky i likuvannia liambliozu u ditei [Problems of diagnosis and treatment of giardiasis in children]. Ukrainskyi medychnyi almanakh [Ukrainian Medical Almanah], 15 (6), 92-95 [in Ukrainian].

Stepanian I.E. (2006). Differentsialnaya diagnostika legochnykh eozinofiliy i infiltratov infektsionnoy prirody [Differential diagnosis of pulmonary eosinophilias and infiltrates of infectious nature]. Prakticheskaya pulmonologiya [Practical Pulmonology], (1), 10-13 [in Russian].

Guila, A.V., Ginda, S.S., & Iaskina, V.E. (2015). Kharakteristika limfotsitov T u bolnykh s sochetaniem tuberkuleza legkikh i toksokaroza [Characteristics of T lymphocytes in patients with a combination of pulmonary tuberculosis and toxocariasis]. Meditsinskiy Alyans [Medical Alliance], (1), 64-65 [in Russian].

Kolpakova, T.A. (2011). Problema komorbidnosti v klinike legochnogo tuberkuleza [The problem of comorbidity in the pulmonary tuberculosis clinic]. Klinicheskaya meditsina. Byulleten Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy Akademii meditsinskikh nauk [Journal of the East Siberian Scientific Center SBRAMS], 78 (2), 48-51 [in Russian].

Kotlyarov, P.M. (2015). Luchevaya diagnostika parazitarnikh zabolevaniy legkikh [Radiodiagnostics of parasitic diseases of the lungs]. Vestnik rossiyskogo nauchnogo Tsentra rentgenoradiologii minzdrava Rossii – Journal of the Russian Scientific Center of Roentgenology Radiology of the Ministry of Health of Russia, (4), 51-63 [in Russian].

Osipova, S.O., Davis, N.A., Islamova, Zh.I., & Syrov, V.N. (2010). Sostoyanie pecheni u bolnykh tuberkulezom legkikh s soputstvuyushchimi kishechnymi parazitozami [Status of the liver in patients with pulmonary tuberculosis and concomitant intestinal parasites]. Zhurnal infektologii [Journal of Infectology], 2 (4), 96-97 [in Russian].

Yoshiaki Iwashita, Kei Suzuki, Asami Masui, & Eiji Kawamoto Iwashita (2013). A case of Strongyloides hyperinfection associated with tuberculosis. J. Intensive Care, (1), 7.

Hwang, E.H., Ahn, P.G., Lee, D.M., & Kim, H.S. (2012). Cerebral toxoplasmosis combined with disseminated tuberculosis. J.Korean Neurosurg. Society, 51, 316-319.

Guneratne, R., Mendis, D., Bandara, T., & Fernando, S.D. (2011). Toxoplasma, toxocara and tuberculosis co-infection in a four year old child. BMC Pediatr., 11, 44.

Saeed, M.Y., Ahmed, A.H., Elhassan, N.B., & Elhassan, A.M. (2009). Concomitant tuberculosis and hydatid cyst in a solitary pulmonary nodule of left lower lobe. BMJ Case Rep. doi: 10.1136/bcr.04.2009.1738

Valadas, E., Gomes, A., Sutre, A., Briiha, S., & Wete, A. (2013). Tuberculosis with malaria or HIV co-infection in a large hospital in Luanda, Angola. J. Infect. Dev. Ctries, 7 (3), 269-272.

Voytsekhovskiy, V.V., Landyshev, Yu.S., Tseluyko, S.S. (2015). Eozinofilii [Eosinophilia]. Amurskiy meditsinskiy zhurnal [Amur Medical Journal], 9 (1), 6-17 [in Russian].

Kolobovnikova, Yu.V., Urazova, O.I., Novitskiy, V.V., & Churina, E.G. (2014). Patogeneticheskie faktory immunosupressii pri tuberkuleze legkikh s eozinofiliyey [Pathogenetic factors of immunosuppression in pulmonary tuberculosis with eosinophilia]. Vestnik nauki Sibiri [Journal of Siberian Science], 14 (4), 272-276 [in Russian].

Abate, E., Belayneh, M., Gelaw, A., Idh, J., Getachew, A., Alemu S., … & Schön T. (2012). The impact of asymptomatic helminth co-infection in patients with newly diagnosed tuberculosis in North-West Ethiopia. PLoS ONE, 7 (8): e42901. https://doi.org/10.1371/journal.pone.0042901

Parakkal Jovvian, G., Pavan Kumar, N., Rathinam Sridhar, Luke, E. H., Nair, D. … & Subash Babu (2014). Coincident helminth infection modulates systemic inflammation and immune activation in active pulmonary tuberculosis. PLoS Negl. Trop. Dis., 8 (11). e3289.

McSorley, H.J., Hewitson, J.P., & Maizels R.M. (2013). Immunomodulation by helminth parasites: Defining mechanisms and mediators. Intern. J. Parasitology, (43), 301-310.

Hűbner, M.P., Layland L.E., & Hoerauf, A. (2013). Helminths and their implication in sepsis – a new branch of their immunomodulatory behaviour? Pathogens and Disease, (69), 127-141.

Ezenwa, V.O., & Jolles A.E. (2011). From host immunity to pathogen invasion: the effects of helminth coinfection on the dyna­mics of microparasites. Integrative and Comparative Biology, 51 (4), 540-551.

Blackwell, A.D., Martin, M., Kaplan, H., & Gurven, M. (2013). Antagonism between two intestinal parasites in humans: the importance of co-infection for infection risk and recovery dynamics http://dx.doi.org/10.1098/rspb.2013.1671

Loboda, V.F., Hlushko, K.T., & Dobrovolska, L.I. (2012). Aktualnist parazytarnykh zakhvoriuvan u ditei z patolohiieiu orhaniv travlennia [Actuality of parasitic diseases in children with pathology of digestive organs]. Visnyk naukovykh doslidzhen [J. Sci. Res.], (4), 87-89 [in Ukrainian].

Pesotckaya, L.A., Evstigneev, I.V., Nikoneko, V.A., & Opryatnaya, T.O. (2012). Sluchai legochnoy formy askaridoza u bolnogo so mnozhestvennoy mielomoy [Case of a pulmonary form of ascaridosis in a patient with multiple myeloma]. Ukrainskyi medychnyi chasopys [Ukrainian Medical Journal], 87 (1), 134-135 [in Russian].

Li-Guang Tian, Jia-Xu Chen, Tian-Ping Wang, Guo-Jin Cheng, Peter Steinmann, Feng-Feng Wang … & Xiao-Nong Zhou (2012). Co-infection of HIV and intestinal parasites in rural area of China. Parasites & Vectors, 5 (1), 530.

Zaccone, P., & Cook, A. (2013). Helminth mediated modulation of Type 1 diabetes (T1D). Intern. J. Parasitology, (43), 311-318.

Vasylieva, N.А., & Shkilna, М.І. (2009). Zastosuvannia meratynu v kompleksnomu likuvanni khvorykh na alerhodermatozy iz suputnim liambliozom [Application of meratine in complex treatment of patients with allergodermatoses and contaminant lambliasis]. Infektsiini khvoroby [Infectious Diseases], (1), 45-47 [in Ukrainian].

Halliez, M.C.M., & Buret, A. G. (2013). Extra-intestinal and long term consequences of Giardia duodenalis infections. World J. Gastroenterology, 47(19), 8974-8985.

Shkilna, М.І. (2008). Laboratorna diahnostyka liambliozu [Laboratory diagnosis of lambliosis]. Infektsiini khvoroby [Infectious Diseases], (4), 43-46 [in Ukrainian].

Published

2017-11-06

How to Cite

Melnyk, L. P., Hryshchuk, L. A., Vasylieva, N. A., & Shkilna, M. I. (2017). THE COURSE OF COMBINED COEXISTENCE OF TUBERCULOSIS AND LAMBLIOSIS. Infectious Diseases – Infektsiyni Khvoroby, (3), 52–58. https://doi.org/10.11603/1681-2727.2017.3.8227

Issue

Section

Original investigations