NERVOUS SYSTEM AFFECT CAUSED BY VARICELLA-ZOSTER VIRUS IN CHILDREN
DOI:
https://doi.org/10.11603/1681-2727.2017.3.8224Keywords:
сhickenpox, complications, encephalitis, ischemic stroke, children.Abstract
The aim of the work – to study the peculiarities of the clinical course of specific neurological complications in children associated with Varicella-Zoster virus.
Patients and methods. This study focused on 47 children with neurological complications of сhickenpox ranging in age from 2 months to 17 years old, who were admitted to the Lviv Region Infectious Diseases Hospital (LRIDH) during 2000-2016. The diagnosis of сhickenpox was based on typical clinical manifestations of the disease, epidemiological history, the results of conventional laboratory and immunological studies.
Conclusions. Atactic form of encephalitis which was diagnosed in 80.9 % of children with сhickenpox, developed during the recession of the acute stage of the disease – during the period of drying crusts, and was characterized by benign course that indicates infectious and allergic genesis of this neurological complication. Focal encephalitis, caused by the direct effect of the Varicella-Zoster virus, was observed in 12.5 % of children. The first clinical symptoms of diffuse lesions of cerebral matter and cranial nerves arose in the early stages of the disease (2-4 days). Among other neurological complications of сhickenpox purulent meningitis (2.1 %), Reye’s syndrome (2.1 %), ischemic stroke (2.1 %) were diagnosed. Ischemic stroke as a complication of infectious vasculitis associated with Varicella-Zoster, which developed into a 4-year old child, debunks traditional interpretation of сhickenpox as a childhood disease with mild course.
References
Shostakovych-Koretska, L.R., Revenko, H.A., Budaeva, I.V., Danilina, E.S., & Lukianchenko, P.V. (2017). Kliniko-epidemiolohichna kharakterystyka suchasnoi vitrianoi vispy [Clinical and epidemiological characteristics of current varicella]. Semeynaya meditsyna [Family medicine], 1 (69), 145-147 [in Ukrainian]
Podavalenko, A.P., Romanenko, T.A., Тishchenko, V.V., Мoroz, V.A., & Podavalenko, A.V. (2015). Epidemichnyi protses vitrianoi vispy ta faktory ryzyku yoho intensyfikaciyi [Epidemic process of varicella and risk factors of its intensification]. Zhurnal klinichnykh ta eksperymentalnykh medychnykh doslidzhen [Journal of Clinical and Experimental Medical Research], 3 (4), 600-608 [in Ukrainian].
Grahn, A., & Studahl, M. (2015). Varicella-zoster virus infections of the central nervous system – Prognosis, diagnostics and treatment. J. Infect., 71 (3), 281-293.
Kennedy, P.G. (2004). Viral encephalitis: causes, differential diagnosis, and management. J. Neurol. Neurosurg. Psychiatry, 75, 10-15.
Astapov, A.A., Yasinskaya, L.I., & Akulich, A.S. (2015). Kliniko-etiologicheskaya kharakteristika nevrologicheskikh oslozhneniy pri vetryanoy ospe [Clinical-etiologic description of neurological complications at chicken-pox]. Lechebno-profilakticheskie voprosy [Medical and Preventive Questions], (1), 15-17 [in Russian].
Bozzola, E., Bozzola, M., Tozzi, A.E., & Villani, A. (2014). Acute cerebellitis in varicella: a ten year case series and systematic review of the literature. Ital. J. Pediatr., 40, 57.
Bonhoeffer, J., Baer, G., Muehleisen, B., Aebi, C., Nadal, D. & Heininger, U. (2005). Prospective surveillance of hospitalizations associated with varicella-zoster virus infections in children and adolescents. Eur. J. Pediatr., 164, 366-370.
Kramarev, S., Vygovska, O., & Deev V. (2015). Vitriana vispa u ditey v umovakh sohodennia [Varicella]. Z turbotoiu pro dytynu [Taking Care of a Child], 2 (52), 46-51 [in Ukrainian]
Kimirilova, O.G., Kharchenko, G.A., & Galimzyanov, Kh.M. (2011). Gerpesvirusnye entsefality u detey [Herpesviral encephalitis in children]. Astrakhanskiy meditsynskiy zhurnal [Astrakhan Medical Journal], (3), 182-184 [in Russian]
Yılmaz, C., & Çaksen, H. Severe neurological complications of chickenpox. Journal of Pediatric Neurology. Retrieved from: http://www.ejgm.org.
Mueller, N.H., Gilden, D.H., Cohrs, R.J., Mahalingam, R., & Nagel, M.A. (2008). Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency. Neurol. Clin., 26 (3), 675-697.
Nezhoda, I.I., & Levytska, L.I. (2017). Vitriana vispa u ditei [Chickenpox in children]. Infektsiini khvoroby [Infectious diseases], 1 (87), 60-70 [in Ukrainian].
Zinoveva, O.E., Katushkina, E.A., Rogovina, E.G., Scherbanina, V.Yu., Shyshov, A.Y., & Pursanov, M.G. (2010). Ishemicheskiy insult v detskom vozraste [Ischemic stroke in children]. Nevrologicheskiy zhurnal [Neurological Journal], (5), 41-46 [in Russian].
Amlie-Lefond, C., & Jubelt, B. (2009). Neurologic manifestation of varicella zoster virus infection. Curr. Neurol. Neurosci. Rep., 9 (6), 430-434.
Belyaletdinova, I.H., Malinnikova, Yu.E, Mitrofanova, I.V., & Prytkova, M.I. (2016). Porazheniya nervnoy sistemy, vyzvannye virusom Varicella-Zoster u detey [The lesions of the nervous system caused by the Varicella-Zoster Virus in children]. Detskie infektsii [Children’s Infections], (3), 10-15 [in Russian].
Science, M., Mac Gregor, D., Richardson, S.E., Mahant, S., Tran, D., & Bitnun, A. (2014). Central nervous system complications of varicella-zoster virus. J. Pediatr., 165 (4), 779-785.
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