EXPERIENCE OF DETERMINATION OF INTRATHECAL SYNTHESIS OF ANTIBODIES IN PATIENTS WITH DISEASES OF THE CENTRAL NERVOUS SYSTEM
DOI:
https://doi.org/10.11603/1681-2727.2017.3.8223Keywords:
neuroinfections, intrathecal synthesis of specific antibodies.Abstract
The aim of the work – to study the frequency of intrathecal synthesis of specific antibodies at patients with inflammatory lesions of the central nervous system.
Patients and methods. In this work the data of the determination of intrathecal synthesis of specific antibodies (ITSA) in 90 patients are given who were treated at the Lev Hromashevskyi Institute of Epidemiology and Infectious Diseases. The research included quantitative definition of antibodies of the class IgG in serum (S) and cerebrospinal fluid (CSF) to neurotropic pathogens: herpes simplex virus 1/2, cytomegalovirus, Epstein-Barr virus, varicella zoster virus, rubella virus, Borrelies. Calculations of ITSA indicators were carried out according to the method of Reiber H. The condition of a hematoencephalic barrier (HEB) was estimated by means of coefficient of albumine (Qalb) taking into account age norms.
Results. ITSA was established in (25.6±4.6) % of the examined patients with damages of the central nervous system. In patients with ITSA most often (in 52.2 %) simultaneously present antibodies to several neurotropic pathogens. Detection of ITSA at the examined patients didn’t depend on concentration of specific antibodies in S and CSF and wasn’t followed by malfunction of HEB. The incidence of HEB dysfunction at patients with ITSA and without ITSA appeared with an identical frequency (13,0 % and 13,6 % respectively).
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