SERUM LEVELS OF β-2 MICROGLOBULIN AND ITS RELATIONSHIP TO IMMUNOLOGICAL AND HEMATOLOGICAL PARAMETERS IN THE PROGRESSION OF HIV-INFECTION
DOI:
https://doi.org/10.11603/1681-2727.2017.3.8222Keywords:
HIV infection, beta-2-microglobulin, hematological parameters, platelets, ESR.Abstract
The aim of the work – to investigate the relationship between the levels of serum beta-2-microglobulin (B2-MG) and the basic hematological and immunological laboratory parameters in order to determine the predictive potential of the complex use of these factors in HIV infection.
Patients and methods. 135 HIV-infected patients aged 20 to 56 years were involved in the study. Patients were categorized into three groups with the first and second clinical stage of HIV – group 1 (n=30), with the third stage – group 2 (n=28), the fourth stage – group 3 (n=77). The control group comprised 15 practically healthy persons of the corresponding sex and age.
Results. We established a statistically significant difference as markers of immune status and hemograms: platelet and ESR levels in patients with different clinical stages of HIV infection with the greatest deviation of the indicators in the fourth stage of the disease. The study of В2-MG revealed a steady tendency to increase as HIV progression ranged from 8.0 (6.3–9.0) ng/ml at 1–2 stages (first group) to 8.75 (7.1–9.5) ng/ml at stage 3 (group 2) (p<0.05) and 9.0 (8.2–9.5) ng/ml at 4 clinical stages of HIV (group 3) (p<0.001, p<0.05).
References
O’brien, W.A., Hartigan, P.M., Martin, D., Esinhart, J., Hill, A., Benoit, S., ... & Hamilton, J.D. (1996). Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. New England Journal of Medicine, 334 (7), 426-431.
Halota, W., Jaruga, B., & Pawłowska, M. (2002). Serum neopterin and beta2-microglobulin concentration as «prognostic markers» of AIDS. Polski merkuriusz lekarski, 13 (74), 126-128.
Mocroft, A., Johnson, M.A., Sabin, C.A., Bofill, M., Janossy, G., & Phillips, A.N. (1997). The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals. Epidemiology & Infection, 118 (3), 259-266.
Gupta, S. M., Ray, K., & Bala, M. (2004). Evaluation of beta2 microglobulin level as a marker to determine HIV/AIDS progression. J. Сommun. Dis., 36 (3), 166-170.
Wanchu, A., Arora, S., Bhatnagar, A., Sud, A., Bambery, P., & Singh, S. (2004). Beta2 microglobulin as a surrogate marker for HIV infection: good correlation with CD4 counts. Ind. J. Pathology & Microbiology, 47 (2), 298-301.
Hofmann, B., Wang, Y., Cumberland, W.G., Detels, R., Bozorgmehri, M., & Fahey, J.L. (1990). Serum beta2-microglobulin level increases in HIV infection: relation to seroconversion, CD4 T-cell fall and prognosis. AIDS, 4 (3), 207-214.
Onifade, A. A., Emeka, G. J., Olaniyi, J. A., Adeyanju, A. S., Ojerinde, A. O., & Aiku, A. O. (2016). Non-reliability of beta-2 microglobulin and neopterin as short-term immunological markers of HIV progression. African J. Biomed. Res., 19 (3), 205-212.
Volikova, O.A., Shostakovich-Koretskaya, L.R., Litvin, E.Yu., & Kushnerova, E.A. (2014). Prognosticheskoe znachenie β2-mikroglobulina i neopterina na raznikh klinicheskikh stadiyakh VICh-infektsii [Prognostic value of β2-microglobulin and neopterin at different clinical stages of HIV infection]. Medychnyi forum – Medical Forum, 2, 49-54 [in Russian].
Volikova, O.A., Shostakovych-Koretska, L.R., Lytvyn, E.Yu., Kushnerova, E.A., Kriachkova, L.V., & Marhitich, I.M. (2014). Vykorystannia β-2 mikrohlobulinu ta neopterynu dlia prohnozuvannia perebihu VIL-infektsii [β-2 microglobulin and neopterin are used to predict the course of HIV infection]. Aktualni infektsiini zakhvoriuvannia. Klinika, diahnostyka, likuvannia ta profilaktyka: zbirnyk naukovykh practs Ukrainskoi viiskovo-medychnoi akademii – Acute Infectious Diseases. Clinic, Diagnostics, Treatment and Prevention. Collection of Scientific Works of the Ukrainian Military Medical Academy, 40, 381-387 [in Ukrainian].
Volikova, O.A., Shostakovych-Koretska, L.R., Lytvyn, E.Yu., Kushnerova, E.A., Kriachkova, L.V., Marhitich, I.M. … & Symonova, N.V. (2017). Prohnostychne znachennia β2-mikrohlobulinu u VIL-infikovanykh patsiientiv [Prognostic value of β2-microglobulin in HIV-infected patients]. Farmakoterapiia pry infektsiinykh zakhvoriuvanniakh: Materialy naukovo-praktychnoi konferentsii – Pharmacotherapy for infectious diseases. Proceedings of the Conference. Kyiv, April 6-7. (p. 25-26) [in Ukrainian].
Sullivan, P.S., Hanson, D.L., Chu, S.Y., Jones, J.L., Ciesielski, C.A., & Adult/Adolescent Spectrum of Disease Group. (1997). Surveillance for thrombocytopenia in persons infected with HIV: results from the multistate Adult and Adolescent Spectrum of Disease Project. JAIDS, 14(4), 374-379.
Attili, S. V. S., Singh, V. P., Rai, M., Varma, D. V., Gulati, A. K., & Sundar, S. (2008). Hematological profile of HIV patients in relation to immune status – a hospital-based cohort from Varanasi, North India. Turk. J. Hematol, 25 (1), 13-19.
Dikshit, B., Wanchu, A., Sachdeva, R. K., Sharma, A., & Das, R. (2009). Profile of hematological abnormalities of Indian HIV infected individuals. BMC Hematology, 9 (1), 5.
Tsegaye, A., Messele, T., Tilahun, T., Hailu, E., Sahlu, T., Doorly, R. ... & de Wit, T. F. R. (1999). Immunohematological reference ranges for adult Ethiopians. Clinical and Diagnostic Laboratory Immunology, 6 (3), 410-414.
Servais, J., Nkoghe, D., Schmit, J. C., Arendt, V., Robert, I., Staub, T. ... & Hemmer, R. (2001). HIV-associated hematologic disorders are correlated with plasma viral load and improve under highly active antiretroviral therapy. JAIDS, 28 (3), 203-210.
Downloads
Published
How to Cite
Issue
Section
License
Journal Infectious Disease (Infektsiini Khvoroby) allows the author(s) to hold the copyright without registration
Users can use, reuse and build upon the material published in the journal but only for non-commercial purposes
This journal is available through Creative Commons (CC) License BY-NC "Attribution-NonCommercial" 4.0
