MODERN UNDERSTANDING OF THE PATHOGENESIS AND DIAGNOSIS OF SEPTIC CONDITIONS IN CHILDREN (PART I)
DOI:
https://doi.org/10.11603/1681-2727.2017.2.7998Keywords:
sepsis, pathogenesis, diagnostics, children.Abstract
The aim of the work – to summarize the data current views on the etiology and pathogenesis of sepsis in different age groups, including children.
The article adduces the analytical review of the literature on modern views on the pathogenesis, genetic features and diagnostic markers of septic states in children. The first part deals with modern theories of pathogenesis of septic conditions in children. The role of patogenassociate molecular structures Gr+ and Gr- bacteria; the mechanism of their interaction with the receptor cells of the body in which sepsis developing occurs are described. The onset of synthesis of pro- and anti-inflammatory cytokines triggers the pathological cascade of reactions leading to the development of the systemic inflammatory response syndrome and in the subsequent the syndrome of multiple organ failure (SMOF). The features of SMOF in various etiological pathogens of the septic process and the pathogenetic mechanisms of the separated consequences of the transmitted severe sepsis and septic shock are described.
Conclusion. The current depth understanding of the pathogenic mechanisms of sepsis will more effectively diagnose and treat septic conditions, which in turn will reduce mortality and adverse consequences after sepsis suffering in children.References
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