RISK OF THE FETUS AND NEWBORN INFECTION IN PREGNANT WOMEN WITH HBV- AND HCV-INFECTION
DOI:
https://doi.org/10.11603/1681-2727.2017.2.7994Keywords:
HBV-infection, HCV-infection, vertical transmission, pregnancy, fetus, newborn children.Abstract
The aim of the work – to analyze risk factors of vertical transmission (VT) of hepatitis B virus (HBV) and C (HCV) from mother to child to prevent intrauterine infection (IUI) of the fetus and newborn.
Research results. Replicative form of HBV-infection was diagnosed in 32.4 % of pregnant women, carriering of HBV in 67.6 %. In HCV-infected women replicative form of the disease (61%) dominated, and carriering was established in 39% of patients.
In women with replicative forms of HBV- and HCV-infection (4.4 % and 2.8 % accordingly), high viral load and minimal degree of hepatitis activity reproductive losses (early and late miscarriage), missed abortion were observed.
In 8.7 % of pregnant women with replicating form of HBV-infection, high viral load and minimal cytolysis level delivery was held by cesarean section and all children were born not infected.
Conclusions. Vertical transmission of HBV and HCV occurs in case of high viral load in the third trimester of pregnancy, especially before birth and during natural delivery in such women. The degree of hepatitis activity does not affect the risk of perinatal infection.
In women with replicative forms of HBV- and HCV-infection reproductive losses occurred, probably related to increased penetration of viruses through the placenta.
References
Wiseman, E., Fraser, M.A., Holden, S., Glass, A., Kidson, B.L., Heron, L.G., … & Levy, M.T. (2009). Perinatal transmission of hepatitis B virus: viral load and HBеAg status are significant risk factors. Hepatology, 48 (4), 676.
Duda, O.K., Vdovychenko, Iu.P., & Boiko, V.O. (2011). Khronichnyi virusnyi hepatyt C u vahitnykh: kliniko-epidemiolohichni osoblyvosti [Chronic virus Hepatitis C in pregnancy: clinical and epidemiological features]. Zdorove zhenshchiny – Woman’s Health, 2 (58), 87-89 [in Ukrainian].
Chuykova, K.I., Kovaleva, T.A., & Evtushenko, I.D. (2009). Khronicheskie virusnye gepatity B i C vo vremya beremennosti (strategiya minimizatsii riska vertikalnoy peredachi infektsii) [Chronic viral hepatitis B and C during pregnancy (the strategy to minimize the risk of the infection vertical transmission)]. Lechashchiy vrach – Therapist, 11, 68-71 [in Russian].
Yang, J., Zeng, X.M., Men, Y.L., & Zhao, L.S. (2008) Elective caesarean section versus vaginal delivery for preventing mother to child transmission of hepatitis B virus – a systematic review. Virol. J., 28 (5), 100.
Syriopouloua, V., Nikolopouloua, G., Daikosb, G., Theodoridoua, M., & Pavlopouloua, I. (2005). Mother-to-child transmission of hepatitis C virus: rate of infection and risk factors. Scan. Infect. Dis., 37 (5), 350-353.
Giles, M., Garland, S., Grover, S., Lewin, S., & Hellard, M. (2006) Impact of an education campaign on management in pregnancy of women infected with a blood-borne virus. Medical Journal of Australia, 184 (8), 389-392.
Kurtash, N.Ia. (2015). Diahnostyka porushen stanu fetoplatsentarnoho kompleksu u vahitnykh z HBV-infektsiieiu [Diagnosis of the state of fetoplacental complex in pregnant women with a HBV infection]. Zdorove zhenshchiny – Woman’s Health, 1 (97), 179-181 [in Ukrainian].
Andreychin, M.A., & Randyuk, Yu. (2005). Perenatalnoe infitsirovanie virusom gepatita B i C: patomorfologicheskie mekhanizmy i morfofunktsionalnoe sostoyanie platcenty [Perinatal infection with hepatitis B and C virus: the pathomorphological mechanisms and the morphofunctional state of the placenta]. Mezhdunarodnyy meditsinskiy zhurnal – International Medical Journal, 11 (1), 103-107 [in Russian].
Iakovlieva, Ie.B., & Holodenko, Iu.M. (2008). Osoblyvosti patomorfolohii platsenty pry hepatyti C [Features of the pathomorphology of the placenta in hepatitis C]. Ukrainskyi medychnyi almanakh – Ukrainian Medical Almanac, 11 (3), 199-200 [in Ukrainian].
Muzyka, O.P. (2013). Features of pregnancy and the fetus in women with hepatitis C. Candidate’s Extended abstract. Institute of Pediatric, Obstetric and Gynecology of National Academy of Medical Sciences of Ukraine, Kyiv [in Ukrainian].
Arendar, O.A. (2009). Prohnozuvannia ta profilaktyka vertylalnoi / (perynatalnoi) transmisii virusu hepatytu C [Prediction and prevention of vertical / (perinatal) transmission of hepatitis C virus]. Candidate’s Extended abstract. National Medical University named after O.O. Bohomolets, Kyiv [in Ukrainian].
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