EFFICIENCY AND DYNAMIC ANTIVIRALTHERAPY AND INDICATORS OF QUALITY OF LIFE IN PATIENTS WITH CHRONIC HEPATITIS C DEPENDING ON AVAILABILITY MIXED CRYOGLOBULIN
DOI:
https://doi.org/10.11603/1681-2727.2016.4.7209Keywords:
chronic hepatitis C, and mixed cryoglobulinemia, liver fibrosis, antiviral treatment.Abstract
The work included 71 patients with chronic hepatitis C with the stages of liver fibrosis F 3-4, who received antiviral treatment. It is shown that the presence of mixed cryoglobulinemia in these patients had a negative impact on the frequency of achieving sustained virological response (42,1% vs 71,4%, p<0,05) and required medical correction of side effects of treatment in 10,5 % of patients. Among patients with a sustained virologic response in 70,8% of patients recorded disappearance of mixed cryoglobulinemia against 3,0% of patients who do not respond to treatment (p<0,01). Patients with mixed cryoglobulinemia presence of quality of life was worse due to lower performance-emotional role functioning, and social functioning, compared with healthy subjects (p<0.05). In patients with chronic hepatitis C with advanced fibrosis and liver mixed cryoglobulinemia who achieved sustained virological response, higher quality of life than patients who do not respond to treatment or had a relapse (p<0,05-0,01).References
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