IMPROVING THE EFFICIENCY OF HAART WITH METHADONE AND BUPRENORPHINE TREATMENT IN HIV-INFECTED INJECTING DRUG USERS
DOI:
https://doi.org/10.11603/1681-2727.2016.3.6885Keywords:
HIV, HAART, CD4-lymphocyte, HIV viral load, buprenorphine, methadone, injecting drug users.Abstract
The study evaluated the impact of methadone (buprenorphine) maintenance treatment (MMT) on immunological and virological efficiency of HAART in HIV-infected injecting drug users (IDUs). 65 HIV-infected patients, IDUs, were under the supervision and they were divided into two groups. The first group included 33 patients who were on MMT with methadone or buprenorphine. The second group included 32 patients who did not receive MMT. After the enrollment, all patients started receiving HAART. It was found that in patients with HIV infection the substitution maintenance therapy significantly increases the immunological and virological efficiency of HAART after the 12 months of treatment, increases the efficiency of clinical examination, and allows starting HAART in time at the absence of severe immunosuppression, which significantly improves the immunological effectiveness of HAART.References
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