DISTRIBUTION OF METALLO-β-LACTAMASE PRODUCING STRAINS AMONG POLY-DRUG RESISTANT NON-FERMENTING GRAM-NEGATIVE BACILLI IN THE MODERN PERIOD IN UKRAINE
DOI:
https://doi.org/10.11603/1681-2727.2016.2.6524Keywords:
metallo-β-lactamases, antibiotic resistance, non-fermenting Gram-negative bacilli, Pseudonomas, Acinetobacter.Abstract
Among poly-drug resistant non-fermenting gram-negative bacilli (NFGNB), isolated from patients of surgical departments of hospitals located in different regions of Ukraine, 54.0-56.0 % of strains were detected as producers of metallo-β-lactamases (MβL) – enzymes that induce high-level resistance to carbapenem antibiotics. All strains were resistant to cephalosporins and had low susceptibility to non-β-lactam antibiotics. The most active antibiotic against polyresistant Acinetobacter baumannii was netillin (68 %), polyresistant strains of Pseudomonas aeruginosa maintained susceptibility only to imipenem (29.6 %).
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