AUTONOMIC DYSFUNCTION IN PATIENTS WITH HIV-INFECTION RECEIVING ANTIRETROVIRAL THERAPY: STUDY OF HEART RATE VARIABILITY

Authors

  • Kh. I. Vozna
  • V. D. Moskaliuk

DOI:

https://doi.org/10.11603/1681-2727.2016.2.6517

Keywords:

HIV-infection, heart rate variability, highly active antiretroviral therapy, molsydomin.

Abstract

The dynamics of changes in time and spectral parameters of heart rate variability in 44 HIV-infected patients are analizyed in the article. The patients received highly active antiretroviral therapy and treatment, complete with nitric oxide donor – molsydomin. It is shown that the additional inclusion of molsydomin in treatment of HIV-infected patients helps to restore autonomic balance by reducing sympathicotonia.

References

Compostella C. Cardiovascular autonomic neuropathy in HIV-positive african patients / C. Compostella, L. Compostella, R. DElia // Minerva cardioangiologica. – 2008. – Vol. 56. – P. 417-428.

Power spectral analysis of heart rate variability in HIV-infected and AIDS patients / [D. Correia, D.E. Rodrigues, L.A. Resende et al.] // PACE. – 2006. – Vol. 29. – P. 53-58.

Autonomic dysfunction as a predictor of heart disease in human immunodeficiency virus (HIV) / [Y. Elnahar, M. Bisharat, J. Daoko et al.] // J. AIDS HIV Res. – 2013. – Vol. 5, N 1. – P. 1-11.

Heart rate variability and autonomic function tests in HIV positive individuals in India / [A. Sakhuja, A. Goyal, A.K. Jaryal et al.] // Clin. Auton. Res. – 2007. – Vol. 17, N 3. – P. 193-196.

Yun A.J. Modulation of host immunity by HIV may be partly achieved through usurping host autonomic functions / A.J. Yun, P.Y. Lee, K.A. Bazar // Med Hypotheses. – 2004. – Vol. 63. – P. 362-366.

Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia / [D.S. Chow, R. Wood, J. Choi et al.] // HIV Clin. Trials. – 2011. – Vol. 12, N 3. – P. 141-150.

Chimelli L. Degenerative and inflammatory lesions in sympathetic ganglia: further morphological evidence for an autonomic neuropathy in AIDS / L. Chimelli, A. R. Martins // J. NeuroAIDS. – 2002. – Vol. 2. – P. 67-82.

Zaporozhan V.M. VIL-infektsiia i SNID / V.M. Zaporozhan, M.L. Ariaiev. – K.: Zdorovia, 2004. – 636 s.

Malpas S.C. Sympathetic nervous system overactivity and its role in the development of cardiovascular disease / S.C. Malpas // Physiol Rev. – 2010. – Vol. 90. – P. 513-517.

Ramchandra R. Nitric oxide and sympathetic nerve activity in the control of blood pressure / R. Ramchandra, C.J. Barret,

S.C. Malpas // Clin. Exp. Pharmacol. Physiol. – 2005. – Vol. 32,

N 5-6. – P. 440-446.

Prevalence of metabolic syndrome in HIV infected patients receiving highly active antiretroviral therapy using International Diabetes Foundation and adult treatment panel III criteria / [K. Samaras, H. Wand, M. Law et al.] // Diabetes Care. – 2007. – Vol. 30. – R. 113-119.

Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection / [H. Wand, A. Calmy, D.L. Carey et al.] // AIDS. – 2007. – Vol. 21,

N 18. – R. 2445-2453.

Effects of HIV infection and antiretroviral therapy on the heart and vasculature / [M.P. Dubé, S.E. Lipshultz, C.J. Fichtenbaum et al.] // Circulation. – 2008. – Vol. 118. – R. e36-e40.

Starkova N.T. Metabolicheskij sindrom insulinorezistentnosti: osnovnaya koncepciya i sledstvie: obzor / N.T. Starkova, I.V. Dvoryashina // Terapevt. arkh. – 2004. – № 10. – S. 54-58.

Lechenie VICh-infekcii / [M. Al'tfel'd, G. Berens, P. Braun i dr.]; pod. red. K. KHoffman, Yu.K. Rokshtro. — M.: R. Valent, 2012. — 736 s..

Decreased heart rate variability in HIV positive patients receiving antiretroviral therapy: importance of blood glucose and cholesterol / [G. Askgaard, U.S. Kristoffersen, J. Mehlsen et al.]. // PLoS ONE. – 2011. – Vol. 6. – P. e20196.

Klinichnyi protokol antyretrovirusnoi terapii VIL-infektsii u doroslykh ta pidlitkiv. – Zatverdzheno nakazom MOZ Ukrainy № 551 vid 12.07.2010 r.: http://mozdocs.kiev.ua/view.php?id=11177.

Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use // Circulation. – 1996. – Vol. 93. – R. 1043-1065.

Zharinov O.I. Doslidzhennia variabelnosti rytmu sertsia: chy ziavliatsia novi uzghodzheni rekomendatsii? / O.I. Zharinov,

U.P. Cherniaha-Roiko // Ukr. kardiol. zhurn. – 2007. – № 6. – S. 98-102.

Bokeriya L.A. Variabel'nost' serdechnogo ritma: metody' izmereniya, interpretaciya, klinicheskoe ispol'zovanie / L.A. Bokeriya, O.L. Bokeriya, I.V. Volkovskaya // Annaly' aritmologii. – 2009. – № 4. – S. 21-32.

Yabluchanskij N.I. Variabel'nost' serdechnogo ritma v pomoshh' prakticheskomu vrachu / N.I. Yabluchanskij, A.V. Marty'nenko. – KHar'kov, 2010. – 131 s.

Autonomic dysfunction in HIV patients on antiretroviral therapy: studies of heart rate variability / [A. Lebech, U.S. Kristoffersen, J. Mehlsen et al.] // Clin. Physiol. Funct. Imaging. – 2007. – Vol. 27. –

R. 363-367.

Post-exercise heart rate recovery in HIV-positive individuals on highly active antiretroviral therapy. Early indicator of cardiovascular disease? / [W.T. Cade, D.N. Reeds, S. Lassa-Claxton et al.]. // HIV Med. – 2008. – Vol. 9. – P. 96-100.

Protease inhibitors and cardiac autonomic function in HIV-infected patients: a cross-sectional analysis from the Strategies for Management of Antiretroviral Therapy (SMART) Trial / [E.Z. Soliman, M.P. Roediger, D.A. Duprez et al.] // BMJ Open. – 2013. – Vol. 3. –

P. e002523.

Heart rate variability in HIV patients, diabetics, and controls: The AGATAA Study / [I.M. Bensenor, M. Eira, E.L. Dorea et al.] // ISRN Vascular Medicine. – 2011. – Article ID 876864, 8 p.

Published

2016-06-23

How to Cite

Vozna, K. I., & Moskaliuk, V. D. (2016). AUTONOMIC DYSFUNCTION IN PATIENTS WITH HIV-INFECTION RECEIVING ANTIRETROVIRAL THERAPY: STUDY OF HEART RATE VARIABILITY. Infectious Diseases – Infektsiyni Khvoroby, (2), 25–29. https://doi.org/10.11603/1681-2727.2016.2.6517

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