STATE OF SPECIFIC IMMUNITY TO ENDOTOXIN FOR PATIENTS WITH BRONCHIAL ASTHMA WITH THE FIXED/ CIRCULATING OBSTRUCTION
DOI:
https://doi.org/10.11603/1681-2727.2016.1.5961Abstract
SUMMARY. The study included 331 patients with asthma.
Depending on the degree of post-bronhodilyatatsionoho
ratio of FEV1/FVC there were identified 151 patients
with fixed and 180 with reversible obstruction. Levels of
anti-endotoxin antibodies of A, M, G classes and sCD14
were determined by ELISA. The results showed that
the level of ant-endotoxin IgG was significantly higher
(P<0.001) in both control groups, while the level of this
immunoglobulin was significantly higher (P<0.05) in
patients with fixed obstruction compared to reversible
one. A concentration of sCD14 in induced sputum was
significantly higher (P <0.001) compare to control in
both study groups, although the level of this mediator in
serum was significantly higher (P<0.05) only in patients
with reversible obstruction.
Key words: bronchial asthma, endotoxin, immunity.
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