ASSOCIATION OF POLYMORPHISMS OF GENES ACUTEPHASES PARAMETERS IN PATIENTS WITH NEWLY DIAGNOSED PULMONARY TUBERCULOSIS
DOI:
https://doi.org/10.11603/1681-2727.2015.4.5518Abstract
SUMMARY. We examined 150 patients with newly diagnosed pulmonary tuberculosis (NDPT) and 30 healthy donors (HD). It was determined the level of interleukin-2 (IL-2) and C-reactive protein (CRP) in the serum of venous blood ELISA method. In addition, it was investigated polymorphism T330G gene IL-2 and C3872T – CRP in human hennomi by polymerase chain reaction.
Before the chemotherapy in patients with NDPT, there was a significant increase in IL-2 and CRP when compared with the HD. After the two-month standard therapy was observed a significant decrease in IL-2 and CRP. High changes IL-2 and CRP was significantly associated with a mutation homozygotes polymorphism T330G gene IL-2 and C3872T – CRP in patients with NDPT.
Mutation homozygous polymorphism T330G gene IL-2 and C3872T – CRP, which determines the level of production of the studied parameters, is a significant factor in susceptibility to NDPT.
Key words: pulmonary tuberculosis, immunity, gene polymorphism, acutephases parameters, interleukin-2, C-reactive protein.
References
Література
Bloom B.R. The evolving relation between humans and Mycobacterium tuberculosis / B.R. Bloom, P.M. Small // N. Engl. J. Med. – 1998. – N 10. – P. 677-680.
Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese / [H.W. Tso, W.K. Lp, W.P. Chong et al.] // Genes. Immun. – 2005. – Vol. 6, N 4. – P. 358-363.
Butov D.O. Dynamika imunolohichnykh hostrofazovykh pokaznykiv krovi u khvorykh na retsydyv tuberkulozu lehen u protsesi likuvannia / D.O. Butov // Tuberkuloz, lehenevi khvoroby, VIL-infektsiia. – 2013. – №.3. – S. 28-32.
Differential early posttransplant cytokine responses in living and cadaver donor renal allografts / [M. Sadeghi, V. Daniel, R. Weimer et al.] // Transplantation. – 2003. – Vol. 75, N 8. – P. 1351-1355.
Intracellular IFN-γ and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients / [O. Millán, L. Rafael-Valdivia, E. Torrademé et al.] // Cytokine. – 2013. – Vol. 61, N 2. – P. 556-564.
C-reactive protein-mediated suppression of nephrotoxic nephritis: role of macrophages, complement, and Fcγ receptors / [W. Rodriguez, C. Mold, M. Kataranovski et al.] // J. Immunol. – 2007. – Vol. 178, N 1. – P. 530-538.
Crystal structure of Fcγ receptor I and its implication in high affinity γ-immunoglobulin binding / [J. Lu, J.L. Ellsworth, N. Hamacher et al.] // J. Biol. Chem. – 2011. – Vol. 286, N 47. – P. 40608-40613.
Lapach S.N. Statystycheskye metody v medykobyolohycheskykh yssledovanyiakh s yspolzovanyem Excel / S.N. Lapach, A.V. Chubenko, P.N. Babych. – K.: Moryon, 2000. – 320 s.
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