BACTERIAL QUORUM SENSING AS A MEANS OF COMMUNICATION IN BIOFILMS
DOI:
https://doi.org/10.11603/1681-2727.2026.1.16164Keywords:
quorum sensing – QS, biofilm, bacteria, virulence, antibiotic resistance, quorum quenching, QQAbstract
Summary. There is no doubt that the bacteria forming human microbiome exist in biofilms. This is a way for bacteria to survive under the influence of many unfavorable host’s factors and the environment. Within biofilms bacteria can communicate through a special quorum sensing (QS) system, which allows them to change their functioning mechanisms depending on population density, increase their virulence, or to maintain their resistance to a range of antibacterial agents.
Some molecular mechanisms of QS both of n Gram-positive and Gram-negative bacteria has been described. According to the different intrinsic signaling molecules, several types of bacterial QS signaling systems have been identified. One of them is the QS system with acyl-homoserine lactone as an intrinsically induced molecule, which exists in Gram-negative bacteria. The second type is associated with oligopeptides and exists in Gram-positive bacteria. The other types are QS systems using furanborate diesters as self-induced molecules are synthesized both in Gram-negative and Gram-positive bacteria. The role of QS system in the development of pathogenic properties and antimicrobial resistance of pathogens such as S. aureus, P. aeruginosa, B. fragilis, which quite often cause nosocomial infections, was analyzed. The possibilities of exogenous coordinated intervention in QS mechanisms and quorum quenching system to suppress bacterial virulence and prevent transfer antimicrobial resistance genes, were outlined.
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- Автори залишають за собою право на авторство своєї роботи та передають журналу право першої публікації цієї роботи, яка через [ВКАЖІТЬ ПЕРІОД ЧАСУ] з дати публікації автоматично стає доступною на умовах ліцензії Creative Commons Attribution License, котра дозволяє іншим особам вільно розповсюджувати опубліковану роботу з обов'язковим посиланням на авторів оригінальної роботи та першу публікацію роботи у цьому журналі.
- Автори мають право укладати самостійні додаткові угоди щодо неексклюзивного розповсюдження роботи у тому вигляді, в якому вона була опублікована цим журналом (наприклад, розміщувати роботу в електронному сховищі установи або публікувати у складі монографії), за умови збереження посилання на першу публікацію роботи у цьому журналі.
Політика журналу дозволяє і заохочує розміщення авторами в мережі Інтернет (наприклад, у сховищах установ або на особистих веб-сайтах) рукопису роботи, як до подання цього рукопису до редакції, так і під час його редакційного опрацювання, оскільки це сприяє виникненню продуктивної наукової дискусії та позитивно позначається на оперативності та динаміці цитування опублікованої роботи (див. The Effect of Open Access).
Accepted 2026-04-18
Published 2026-04-20
