CLINICAL AND RADIOLOGICAL CHARACTERISTICS AND TREATMENT EFFICACY OF DRUG-RESISTANT PULMONARY TUBERCULOSIS IN PATIENTS WITH HIV INFECTION UNDER CRISIS CONDITIONS
DOI:
https://doi.org/10.11603/1681-2727.2025.4.15756Keywords:
HIV infection, drug-resistant pulmonary tuberculosis, treatment, mortalityAbstract
SUMMARY. One of the clinical challenges in the treatment of pulmonary tuberculosis (TB) in patients with HIV infection is the atypical clinical presentation of the disease. Mortality from TB in the setting of HIV infection is a complex phenomenon caused by the synergistic interaction of both diseases and a range of clinical and socioeconomic factors.
Objective. To study the clinical and radiological features and treatment efficacy in patients with drug-resistant pulmonary tuberculosis and HIV infection under crisis conditions.
Patients and methods. The data of 70 patients with drug-resistant pulmonary TB treated at the Zaporizhzhia Regional Phthisiopulmonology Clinical Diagnostic Center during 2020–2022 were analyzed.
Results. Night sweats were more frequently observed in patients with TB/HIV coinfection compared to those with pulmonary TB alone. Infiltrative forms of TB with cavitary lesions predominated. Timely initiation of ART in HIV-positive patients, optimization of integrated TB/HIV treatment, enhanced adherence support, and prevention of opportunistic infections were noted. However, a higher rate of treatment failures and fatal outcomes remains.
Conclusions. The coexistence of drug-resistant pulmonary TB and HIV infection remains a pressing problem, highlighting the importance of improving treatment effectiveness.
References
Chemych, M. D., Sosnovenko, D. S., & Yanchuk, S. M. (2021). Neuroimmunological changes in early diagnostics of HIV infection. Infectious Diseases, 3, 68–74. https://doi.org/10.11603/1681-2727.2021.3.12497 DOI: https://doi.org/10.11603/1681-2727.2021.3.12497
Hamada, Y., Getahun, H., Tadesse, B. T., & Ford, N. (2021). HIV-associated tuberculosis. International Journal of STD & AIDS, 32(9), 780–790. https://doi.org/10.1177/0956462421992257 DOI: https://doi.org/10.1177/0956462421992257
Sakhelashvili, M. I., Piskur, Z. I., Sakhelashvili-Bil, O. I., & Yurchenko, I. (2025). Course of HIV/AIDS-associated pulmonary tuberculosis by sensitivity of MBT strains. Infusion & Chemotherapy, 2, 13–19. https://doi.org/10.32902/2663-0338-2025-1-13-19 DOI: https://doi.org/10.32902/2663-0338-2025-1-13-19
Todoriko, L., Pidverbetskyi, O., Pidverbetska, O., & Shevchenko, O. (2024). Impact of military conflict in Ukraine on the achievement of the goals of the WHO “End TB” strategy. Infusion & Chemotherapy, 7(4), 28–34. https://doi.org/10.32902/2663-0338-2024-4-28-34 DOI: https://doi.org/10.32902/2663-0338-2024-4-28-34
Pikas, O. B., & Semeniuk, M. A. (2024). Clinical and epidemiological features of tuberculosis in Ukraine (Review). Tuberculosis, Lung Diseases, HIV Infection (Ukraine), 2, 93–98. https://doi.org/10.30978/TB2024-2-93 DOI: https://doi.org/10.30978/TB2024-2-93
Yang, N., He, J., Li, J., Zhong, Y., Song, Y., & Chen, C. (2023). Predictors of death among TB/HIV co-infected patients on tuberculosis treatment in Sichuan, China: A retrospective cohort study. Medicine (Baltimore), 102(5), e32811. https://doi.org/10.1097/MD.0000000000032811 DOI: https://doi.org/10.1097/MD.0000000000032811
Derseh, N. M., Agimas, M. C., Aragaw, F. M., Birhan, T. Y., Nigatu, S. G., Alemayehu, M. A., Tesfie, T. K., Yehuala, T. Z., Godana, T. N., & Merid, M. W. (2024). Incidence rate of mortality and its predictors among tuberculosis and human immunodeficiency virus coinfected patients on antiretroviral therapy in Ethiopia: Systematic review and meta-analysis. Frontiers in Medicine, 11, 1333525. https://doi.org/10.3389/fmed.2024.1333525 DOI: https://doi.org/10.3389/fmed.2024.1333525
Spooner, E., Reddy, S., Ntoyanto, S., Sakadavan, Y., Reddy, T., Mahomed, S., Mlisana, K., Dlamini, M., Daniels, B., Luthuli, N., Ngomane, N., Kiepiela, P., & Coutsoudis, A. (2022). TB testing in HIV-positive patients prior to antiretroviral treatment. International Journal of Tuberculosis and Lung Disease, 26(3), 224–231. https://doi.org/10.5588/ijtld DOI: https://doi.org/10.5588/ijtld.21.0195
Rahmadhani, W., Aprina, H., & Chamroen, P. (2025). Therapy duration, treatment fatigue from antiretrovirals, and adherence to antiretroviral therapy in people living with HIV: A cross-sectional study. Tuberculosis, Lung Diseases, HIV Infection (Ukraine), 2, 11–16. https://doi.org/10.30978/TB2025-2-11 DOI: https://doi.org/10.30978/TB2025-2-11
Lytvynenko, N. A., Senko, Y. O., Protsyk, L. M., Davydenko, V. V., Korotchenko, S. P., & Senko, T. V. (2021). Optimal methods of psychological support in patients with multidrug-resistant pulmonary tuberculosis and their effect on adherence to treatment. Tuberculosis, Lung Diseases, HIV Infection (Ukraine), 1, 67–75. https://doi.org/10.30978/TB2021-1-67 DOI: https://doi.org/10.30978/TB2021-1-67
Chaban, T. I., Bulda, V. I., Noreiko, S. B., Mialovytska, O. A., & Drevitska, O. O. (2025). The role of the family physician in refuting misconceptions in patients with tuberculosis (Review). Tuberculosis, Lung Diseases, HIV Infection (Ukraine), 2, 93–100. https://doi.org/10.30978/TB2025-2-93 DOI: https://doi.org/10.30978/TB2025-2-93
Ntsame Owono, M. M., Manomba Boulingui, C., Essomeyo Ngue Mebale, M., & Bouyou Akotet, M. K. (2025). Clinico-radiological characteristics and lethality of HIV-tuberculosis coinfection in the Infectiology ward of the Libreville University Hospital, Gabon. South African Journal of Infectious Diseases, 40(1), Article 695. https://doi.org/10.4102/sajid.v40i1.695 DOI: https://doi.org/10.4102/sajid.v40i1.695
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Т. К. Сагайдак, Н. О. Скороходова
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal Infectious Disease (Infektsiini Khvoroby) allows the author(s) to hold the copyright without registration
Users can use, reuse and build upon the material published in the journal but only for non-commercial purposes
This journal is available through Creative Commons (CC) License BY-NC "Attribution-NonCommercial" 4.0
