JAUNDICE IN PREGNANT WOMEN
DOI:
https://doi.org/10.11603/1681-2727.2025.3.15597Keywords:
pregnancy, jaundice, differential diagnosisAbstract
SUMMARY. A modern view of jaundice in pregnant women and their differential diagnosis is presented. In some cases, jaundice can be induced by pregnancy (intrahepatic cholestasis of pregnant women, excessive vomiting of pregnant women, preeclampsia, eclampsia, HELLP-syndrome, acute fatty liver disease), in others – it manifests itself independently of it (infectious and toxic hepatitis, acute cholestasis due to gallstones’ disease or neoplasms, Budd-Chiari syndrome, autoimmune hepatitis, primary sclerosing cholangitis, liver cirrhosis, hemolytic jaundice of various genesis, etc.).
Adequate diagnosis enables timely ethiotropic, symptomatic or pathogenetic therapy, or premature delivery to prevent complications, to reduce risks for mother and child.
References
Дуда, А. К., Голеновский, О. В., Мамчич, В. И., & Чайка, М. А. (2017). Диференціальна діагностика жовтяниць у вагітних і необхідна хірургічна тактика. Сімейна Медицина, 6 (74), 17–21.
Gupta, V., Jain, S. (2018). Jaundice in Pregnancy. Journal, Indian Academy of Clinical Medicine, 19(1). 52-57.
Kumari, A., Sharma, T., & Singh, S. (2022). Liver Disorders in Pregnancy. A Retrospective Study. Journal Of Clinical And Diagnostic Research, 16(2), QC27-QC31. DOI: https://doi.org/10.7860/JCDR/2022/52250.16038
Horgan, R., Bitas, C., & Abuhamad, A. (2023). Intrahepatic cholestasis of pregnancy: a comparison of Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists’ guidelines. American Journal of Obstetrics & Gynecology MFM, 5(3), 100838. DOI: https://doi.org/10.1016/j.ajogmf.2022.100838
Acog, A. (2004). American College of Obstetrics and Gynecology. Practice Bulletin: nausea and vomiting of pregnancy. Obstet Gynecol, 103, 803-14. DOI: https://doi.org/10.1097/00006250-200404000-00045
Tan, P. C., Khine, P. P., Vallikkannu, N., & Omar, S. Z. (2010). Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. Obstetrics & Gynecology, 115(5), 975-981. DOI: https://doi.org/10.1097/AOG.0b013e3181d99290
Jueckstock, J. K., Kaestner, R., & Mylonas, I. (2010). Managing hyperemesis gravidarum: a multimodal challenge. BMC medicine, 8, 1-12. DOI: https://doi.org/10.1186/1741-7015-8-46
Hay, J. E. (2008). Liver disease in pregnancy. Hepatology, 47(3), 1067-1076. DOI: https://doi.org/10.1002/hep.22130
Sonkusare, S. (2008). Hyperemesis gravidarum: a review. Med J Malaysia, 63(3), 272-6.
Giannubilo, S. R., Marzioni, D., Tossetta, G., & Ciavattini, A. (2024). HELLP syndrome and differential diagnosis with other thrombotic microangiopathies in pregnancy. Diagnostics, 14(4), 352. DOI: https://doi.org/10.3390/diagnostics14040352
White, M., Han, H., & Khungar, V. (2024). Acute fatty liver disease of pregnancy. Clinical Liver Disease, 23(1), e0145. DOI: https://doi.org/10.1097/CLD.0000000000000145
Kingham, J. G. (2010). Swansea criteria for diagnosis of acute fatty liver of pregnancy. Gut, gut-2010.
Rios, J., Aliasi-Sinai, L., Schmidt, N., & Kushner, T. (2024). Management of Hepatitis B in Pregnancy. Current Hepatology Reports, 23(2), 278-286. DOI: https://doi.org/10.1007/s11901-024-00659-2
Kamani, L., & Razzak, A. A. (2024). Hepatitis-C during Pregnancy: Antenatal period challenges, management and the way forward. Pakistan Journal of Medical Sciences, 40(1Part-I), 227. DOI: https://doi.org/10.12669/pjms.40.1.7578
Aisha, A., Abbas, S., Eed, E. M., Ahmed, D., Irfan, S., Rehman, F. U., ... & Naeem, M. (2024). Hepatitis E associated determinants and diagnostic biomarkers during pregnancy and its prenatal consequences in Multan, Punjab tertiary care setting (Pakistan). American Journal of Translational Research, 16(5), 2049. DOI: https://doi.org/10.62347/SLWM5449
Huang, D., Lai, H., Shi, X., Jiang, J., Zhu, Z., Peng, J., ... & Chen, J. (2024). Global Temporal Trends And Projections of Acute Hepatitis E Incidence Among Women of Childbearing Age: Age-Period-Cohort Analysis 2021. Journal of Infection, 106250. DOI: https://doi.org/10.1016/j.jinf.2024.106250
Chen, C., Wang, M. L., Li, W. X., Qi, X., Li, Q., & Chen, L. (2024). Hepatitis E virus infection increases the risk of obstetric complications and perinatal adverse outcomes in pregnant women with chronic hepatitis B virus infection. European Review for Medical & Pharmacological Sciences, 28(5).
Brewer, G. J., Johnson, V. D., Dick, R. D., Hedera, P., Fink, J. K., & Kluin, K. J. (2000). Treatment of Wilson’s disease with zinc. XVII: treatment during pregnancy. Hepatology, 31(2), 364-370. DOI: https://doi.org/10.1002/hep.510310216
Merz, W. M., Rüland, A. M., Hippe, V., Poetzsch, B., Meyer, C., Pollok, J. M., ... & Trebicka, J. (2016). Pregnancy in Budd-Chiari syndrome: case report and proposed risk score. Medicine, 95(22), e3817. DOI: https://doi.org/10.1097/MD.0000000000003817
Braga, A., Vasconcelos, C., & Braga, J. (2020). Autoimmune hepatitis and pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology, 68, 23-31. DOI: https://doi.org/10.1016/j.bpobgyn.2020.03.007
Miller, H. M., & Westbrook, R. H. (2022). Pregnancy and Liver Disease. In Liver Disease in Clinical Practice (pp. 261-286). Cham: Springer International Publishing. DOI: https://doi.org/10.1007/978-3-031-10012-3_13
Panchbudhe, S. A., Parulekar, M., & Kudale, S. (2022). Liver Disease in Pregnancy: A Prospective Analysis of Maternal and Fetal Outcomes among 120 Patients at a Tertiary Care Center. Journal of South Asian Federation of Obstetrics and Gynaecology, 14(5), 551-556. DOI: https://doi.org/10.5005/jp-journals-10006-2137
Katke, R. D., Shah, B., Chinchoriya, S., Nawarange, S., Farogh, A., Syed, S., & Vashisth, P. (2021). A Successful Feto-Maternal Outcome In Pregnancy With Wilsons Disease: An Extremely Rare Case Report With Review Of Literature.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 В. С. Копча
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal Infectious Disease (Infektsiini Khvoroby) allows the author(s) to hold the copyright without registration
Users can use, reuse and build upon the material published in the journal but only for non-commercial purposes
This journal is available through Creative Commons (CC) License BY-NC "Attribution-NonCommercial" 4.0
