METAPNEUMOVIRUS INFECTION IN THE WORLD AND UKRAINE: WHAT IS KNOWN AND ARE THERE RISKS?

(PART 1)

Authors

  • V. I. Zadorozhna State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0002-0917-2007
  • N. P. Vynnyk State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0002-5608-005X
  • T. A. Serheieva State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0001-6488-4042

DOI:

https://doi.org/10.11603/1681-2727.2025.1.15151

Keywords:

human metapneumovirus, metapneumovirus infection, epidemic process, surveillance, seasonality, bronchiolitis, pneumonia, vaccines

Abstract

Metapneumovirus (HMPV) can affect the lower respiratory tract. During replication, it can spread from cell to cell, which makes it similar to SARS-CoV-2 in terms of these properties. Risk groups are children who are infected with this pathogen for the first time and older adults with an unfavorable premorbid background accompanied by an immunocompromised state. The most frequent manifestations of infection are bronchiolitis and pneumonia.

There is no specific treatment or vaccine. HMPV is characterized by cyclical circulation, the activity of which has been affected by the COVID-19 pandemic, increasing the intensity of the epidemic process after a certain decline in some areas. In Ukraine, for the period 2019/2020 – 2024/2025 (the first 2 weeks), the highest indicators of the frequency of HMPV detection were against the background of the COVID-19 epidemic in 2020/2021 (1.83–4.33 %). In 2021/2022 only 2 cases of HMPV infection were detected. In the next 2 seasons (2022/2023–2023/2024), HMPV was detected within the sentinel surveillance with a frequency of 1.44 and 1.13 %, respectively, but the number of viruses increased from 63 to 106. In 2024/2025 (the first 2 weeks), the increase in the intensity of НMPV circulation was not determined (according to sentinel surveillance data, НMPV was determined in 0.43–1.11 % of the number of hospitalized patients with acute respiratory infections (ARIs). In 2022/2023 and 2023/2024 НMPV circulated throughout the entire epidemic season of ARIs, but with different intensity. In 2020/2021 circulation began in February 2021, and the peak incidence was observed at the end of March–April. In the 2022/2023 season the highest frequency of detection of НMPV was recorded in November–December 2022 with subsequent sporadic cases until the month of May. In the 2023/2024 season most cases were identified in mid-December with a further slight increase in March–April. It should be noted that in 2020/2021 and 2023/2024 sporadic cases were also registered in May, i.e. until the end of the season/observation (20th week). It can be assumed that the circulation of НMPV continued further. In Ukraine, at present, there has been no increase in the frequency of cases of HMPV infection, which would exceed the limits expected during the epidemic season of ARIs. At the same time, cases of НMPV infection are constantly being determined among patients with a severe course of ARIs, which indicates the relevance of this infectious disease for Ukraine. It has been shown that sentinel surveillance is much more informative than routine surveillance in terms of diagnosing HMPV infection, operational assessment of the epidemic situation and trends in the epidemic process. It is necessary to further improve the system of surveillance for ARIs, in particular for HMPV infection, in order to increase the sensitivity of its informational component. At the moment, there is no reason to talk about the emergence of an emergent, i.e. new to humans, metapneumovirus, as well as the acquisition of new properties by the known HMPV. According to the analyzed data of its role in the development of ARIs in the world and in Ukraine, the current situation can be assessed as a seasonal rise in HMPV infection, which may be more pronounced both in general and in certain areas due to the previous impact of the COVID-19 pandemic.

Author Biographies

V. I. Zadorozhna, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

DSc (Medicine), Professor, Corresponding Member of the NAMS of Ukraine, Director of the

 

N. P. Vynnyk, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

PhD, Senior Researcher of the Department of Epidemiological Analysis and Immunoprophylaxis of the

T. A. Serheieva, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

DSc (Medicine), Senior Researcher, Head of the Laboratory of Epidemiology of Infectious Diseases, Department of Epidemiological Analysis and Immunoprophylaxis of the

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Published

2025-03-06

How to Cite

Zadorozhna, V. I., Vynnyk, N. P., & Serheieva, T. A. (2025). METAPNEUMOVIRUS INFECTION IN THE WORLD AND UKRAINE: WHAT IS KNOWN AND ARE THERE RISKS? (PART 1). Infectious Diseases – Infektsiyni Khvoroby, (1), 9–26. https://doi.org/10.11603/1681-2727.2025.1.15151

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Original investigations