THE ROLE OF PROBIOTIC CULTURES IN THE FORMATION OF THE GUT MICROBIOTA. THE GUT-BRAIN MICROBIOTA AXIS

Authors

DOI:

https://doi.org/10.11603/1681-2727.2024.4.15006

Keywords:

probiotic, intestinal microbiota, enteric nervous system, gut-brain axis, stress

Abstract

Probiotics and prebiotics modulate the gut-brain axis, which has a supportive effect on the central nervous system, and also reduces or controls the incidence of some mental disorders (depression, anxiety, autism, schizophrenia, and Alzheimer’s disease). The commensal microbiota plays a central role in the relationship between the gut microbiota and the central nervous system (the microbiota-gut-brain axis).

The gut-brain axis (GBA) consists of bidirectional communication between the central and enteric nervous systems, linking the emotional and cognitive centers of the brain with peripheral gut functions. As a result, modulation of the gut microbiota is considered a key aspect in the treatment of neurological disorders.

Research shows that the gut microbiome can influence the gut-brain axis and play an important role in the prevention and control of certain brain diseases, such as stress, Alzheimer’s disease, depression and insomnia.

Conclusions: The presented literature data can provide a motivational basis for conducting additional and in-depth research in the study of pathogenetic aspects of anxiety syndromes and stress.

Author Biographies

V. V. Kunovskyi, Danylo Halytsky Lviv National Medical University

PhD, Associate Professor of the Department of General Surgery

O. V. Laba, Danylo Halytsky Lviv National Medical University

PhD, assistant of the Department of Obstetrics, Gynecology and Perinatology, FPED

 

L. M. Kunovska, Danylo Halytsky Lviv National Medical University

assistant of Department of Pediatrics and Neonatology of the Faculty of Postgraduate Education (FPED)

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Published

2024-12-17

How to Cite

Kunovskyi, V. V., Laba, O. V., & Kunovska, L. M. (2024). THE ROLE OF PROBIOTIC CULTURES IN THE FORMATION OF THE GUT MICROBIOTA. THE GUT-BRAIN MICROBIOTA AXIS. Infectious Diseases – Infektsiyni Khvoroby, (4), 43–50. https://doi.org/10.11603/1681-2727.2024.4.15006

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Section

Reviews and lectures