BIOSAFETY, BIOSECURITY AND “DISEASE X”: DEFINITIONS, GLOBAL AND NATIONAL PROBLEMS, WAYS OF SOLUTION

Authors

  • V. I. Zadorozhna State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0002-0917-2007
  • V. R. Shahinian State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0002-2746-3414
  • N. P. Vynnyk State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine” https://orcid.org/0000-0002-5608-005X

DOI:

https://doi.org/10.11603/1681-2727.2024.3.14878

Keywords:

biosafety, biosecurity, biorisks, “disease X”, epidemic, pandemic

Abstract

The paper discusses the issues of modern biological threats, in particular “disease Х”, the consequences of artificial disasters, which can be different in scale and unpredictable in terms of biorisks, etc., approaches to defining the concepts of biological safety and biological protection, as well as ways to improve the biological safety system in Ukraine. Given the diversity of modern bio-threats and bio-risks, the term “biosecurity” should be a broad concept and cover all their elements. Due to the ambiguity of the interpretation of this term in various literature sources, we offer our own vision of it, namely: “Biosafety is the preservation of a state of equilibrium between the human population, flora and fauna, on the one hand, and their pathogens, on the other hand, characterized by the absence or controllability of adverse events that could lead to the spread of particularly dangerous pathogens and cause an emergency in the field of healthcare, animal husbandry or agriculture”.

Ensuring biosecurity is possible through the functioning of an appropriate sustainable biosafety and biosecurity system at the regional and national levels, which is able to properly counter both emerging and routine bio-threats. Although much has already been done in Ukraine to build a biosafety system, it needs further development. It should be a comprehensive system that will involve all relevant central authorities, agencies and organizations at all administrative levels. As for the purely medical component of this system, the main place in it belongs to the epidemiological surveillance system, whose
functions remain supervision, detection, analysis, forecasting, making and implementation of management decisions aimed at preventing and counteracting biorisks.

Author Biographies

V. I. Zadorozhna, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

MD, Professor, Corresponding Member of the NAMS of Ukraine, Director of the State Institution “L. V. Gromashevsky Epidemiology and Infectious Diseases Institute of National Academy of Medical Sciences of Ukraine”

 

V. R. Shahinian, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

MD, Head of the Department of Diagnostics of infectious and parasitic diseases of the State Institution “L. V. Gromashevsky Epidemiology and Infectious Diseases Institute of National Academy of Medical Sciences of Ukraine”

N. P. Vynnyk, State Institution “L. V. Gromashevsky Institute of Epidemiology and Infectious Diseases of National Academy of Medical Science of Ukraine”

PhD, Senior Researcher of the Department of Epidemiological Analysis and Immunoprophylaxis of the State Institution “L. V. Gromashevsky Epidemiology and Infectious Diseases Institute of National Academy of Medical Sciences of Ukraine”

References

Brès, P. L., & World Health Organization. (1986). Public health action in emergencies caused by epidemics: a practical guide. World Health Organization.

NATO’s Chemical, Biological, Radiological and Nuclear (CBRN) Defence Policy. Last updated: 05 Jul. 2022. [E-resource] – Retrieved from https://www.nato.int/cps/en/natohq/official_texts_197768.htm.

Non-binding guidelines for civil-military medical cooperation in response to CBRN mass casualty incidents. NATO. [E-resource] – Retrieved from https://www.nato.int/nato_static_fl2014/assets/pdf/2022/2/pdf/220222-0407-21_Guidelines-Civil-Military.pdf.

Non-binding guidelines for enhanced civil-military cooperation for large-scale CBRN events associated with terrorist attacks. NATO. [E-resource] – Retrieved from https:// www.nato.int/nato_static_fl2014/assets/pdf/2020/4/pdf/200414-guidelines-civmilcoop-cbrn.pdf.

Combined Joint Chemical, Biological, Radiological and Nuclear (CBRN) Defence Task Force. Last updated: 13 Apr. 2022. [E-resource] – Retrieved from https://www.nato.int/cps/en/natohq/topics_49156.htm?selectedLocale=en.

WHO. (2023). One Health. 23 October 2023. [E-resource] – Retrieved from https://www.who.int/news-room/fact-sheets/detail/one-health.

Задорожна, В. І., Шагінян, В. Р., Винник, Н. П. (2024). Від епідемій минулого до сьогодення і хвороби Х, досвід боротьби та перспективи. Превентивна медицина. Теорія і практика, 1(5), 3-15. DOI : https://doi.org/10.61948/prevmed-2024-1-3.

CDC (2024). 2022-2023 Mpox Outbreak Global Map. Data as of 05 Mar.2024 [E-resource] – Retrieved from https://www.cdc.gov/poxvirus/mpox/response/2022/world-map.html.

WHO (2024). Research response to pathogen X during a pandemic. [E-resource] – Retrieved from https://www.who.int/news-room/events/detail/2024/01/19/default-calendar/Research-response-to-pathogen-X-during-a-pandemic.

Blueprint for R&D preparedness and response to public health emergencies due to highly infectious pathogens. WORKSHOP ON PRIORITIZATION OF PATHOGENS. 8-9 December 2015. [E-resource] – Retrieved from https://cdn.who.int/media/docs/default-source/blue-print/blueprint-for-r-d-preparedness-and-response-meeting-report.pdf?sfvrsn=156d23be_2.

Coulson M. (2024). Defining Disease X. Johns Hopkins Bloomberg School of Public Health. [E-resource] – Retrieved from https://publichealth.jhu.edu/2024/what-is-disease-x.

WHO. Prioritizing diseases for research and development in emergency contexts. [E-resource] – Retrieved from https://www.who.int/activities/prioritizing-diseases-for-research-and-development-in-emergency-contexts/prioritizing-diseases-for-research-and-development-in-emergency-contexts.

COVID-19 coronavirus pandemic. Last updated: April 04, 2024. [E-resource] – Retrieved from https://www.worldometers.info/coronavirus/

Tahir, M. J., Sawal, I., Essar, M. Y., Jabbar, A., Ullah, I., Ahmed, A. (2022). Disease X: A hidden but inevitable creeping danger. Infect Control Hosp Epidemiol. Nov;43(11):1758-1759. DOI: 10.1017/ice.2021.342.

Cameron, E. E., Nuzzo, J. B., Bell, J. A. et al. (2019). Global Heath Security Index (GHSI). Available from: https://ghsindex.org/wp-content/ uploads/2019/10/2019-Global-Health-Security-Index.pdf.

Laboratory biosafety manual, fourth edition, WHO, 2020, 100 р. Available from: https://iris.who.int/bitstream/handle/10665/337956/9789240011311-eng.pdf?sequence=1.

Стегній, Б. Т., Герілович, А. П., Ібатуллін, І. І. (2013). Проб­леми біологічної безпеки та біологічного захисту у ветеринарній медицині та біотехнології. Харків: «НТМТ», 414 с.

Biosafety in Microbiological and Biomedical Laboratories, 6th Edition. (2020). CDC. 574 р. Available from: https://www.cdc.gov/labs/pdf/SF__19_308133-A_BMBL6_00-BOOK-WEB-final-3.pdf.

Nambisan, P. (2017). Laboratory biosafety and good laboratory practices. An Introduction to Ethical, Safety and Intellectual Property Rights Issues in Biotechnology, 253. DOI: 10.1016/B978-0-12-809231-6.00011-9.

Safety by Design. (2015). Biosafety Monograph. US. Department of Health and Human Services. Public Health Service. National Institutes of Health. Office of Research Services Division of Occupational Health and Safety, 224 р. Available from: https://ors.od.nih.gov/sr/dohs/Documents/biosafety-monograph.pdf.

Nelsen, A., Language, A., Steenhard, N. R. (2016). Biological Defense: An Effective and Practical Approach. 1st Edition. Center for Biosecurity and Biopreparedness Statens Serum Institutе, Denmark, 312 p.

Wooley, D. P., & Byers, K. B. (Eds.). (2020). Biological safety: principles and practices. John Wiley & Sons. ISBN-10: 1555816207; ISBN-13: 978-1555816209. 741 р.

Schröder, I. (2019). Biological safety: Principles and practices. Emerging Infectious Diseases, 25(1), 195. DOI: 10.3201/eid2501.180458.

Gangadharan, D., Smith, J., Weyant, R. (2013). Centers for Disease Control and Prevention. Biosafety Recommendations for Work with Influenza Viruses Containing a Hemagglutinin from the A/goose/Guangdong/1/96 Lineage. MMWR Recomm Rep. Jun 28, 62(RR-06), 1-7.

Loibner, M., Langner, C., Regitnig, P., Gorkiewicz, G., & Zatloukal, K. (2021). Biosafety requirements for autopsies of patients with COVID-19: example of a BSL-3 autopsy facility designed for highly pathogenic agents. Pathobiology, 88(1), 37-45. DOI: 10.1159/000513438.

Li, X. Y., Xue, K. N., Jiang, J. S., & Lu, X. C. (2016). The main biological hazards in animal biosafety level 2 facilities and strategies for control. Biomedical and Environmental Sciences, 29(4), 300-304. DOI: 10.3967/bes2016.039.

European Commission. Food Safety: Biological Safety. [An official website of the European Union]. Available from: https://food.ec.europa.eu/safety/biological-safety_en.

Yale Environmental Health & Safety. What is biological safety? Available from: https://ehs.yale.edu/what-biological-safety.

Biological Safety Procedure. Department of Engineering Health & Safety. The University of Cambridge. Available from: https://safety.eng.cam.ac.uk/safe-working/coshh-assessment-procedure/biological-safety-1.

Biological safety. Imperial College London. Available from: https://www.imperial.ac.uk/safety/safety-by-topic/laboratory-safety/biological-safety/

Biological Safety. Health and Safety Office. The Hong Kong Polytechnic University. Available from: https://www.polyu.edu.hk/hso/hs-topics/biological-safety/

Величко, М. В., Андрейчин, М. А. (2023). Підготовка спеціа­лістів із біологічної безпеки та біологічного захисту як ключова умова відповідних дієвих заходів. Інфекційні хвороби, 2 (112), 4-8. DOI 10.11603/1681-2727.2023.2.14096.

Андрейчин, М. А., Величко, М. В., Мельник, Л. П., Анд­рейчин, Ю. М. (2023). Світовий досвід з підготовки фахівців із біобезпеки. Медична освіта, 3, 15-25. DOI: 10.11603/m.2414-5998.2023.3.14267.

Published

2024-10-11

How to Cite

Zadorozhna, V. I., Shahinian, V. R., & Vynnyk, N. P. (2024). BIOSAFETY, BIOSECURITY AND “DISEASE X”: DEFINITIONS, GLOBAL AND NATIONAL PROBLEMS, WAYS OF SOLUTION. Infectious Diseases – Infektsiyni Khvoroby, (3), 53–63. https://doi.org/10.11603/1681-2727.2024.3.14878

Issue

Section

Reviews and lectures