COMBINATION OF ANTIBIOTICS AND BACTERIOPHAGES TO COMBAT ANTIBIOTIC-RESISTANT MICROORGANISMS
DOI:
https://doi.org/10.11603/1681-2727.2024.3.14669Keywords:
bacteriophages, phage-antibiotic synergyAbstract
Despite antibiotics being the main method of combating bacterial infections today, the rapid emergence and prevalence of antibiotic resistance generate interest in alternative and supplementary antimicrobial strategies, particularly concerning infections caused by MDR, PDR, and XDR microorganisms. In recent decades, research has been conducted on the use of bacteriophages (phages) and antibiotics either separately or in combination, both in vitro and in vivo. The materials presented in the review indicate the synergistic action of phages and antibiotics when used in combination, although some experiments have shown indifferent effects and even antagonism between phages and antibiotics. Strategies involving the combination of phages and antibiotics are promising, especially concerning biofilms, including their mature forms.
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