A CLINICAL CASE OF RAMSAY-HUNT SYNDROME TYPE II IN A PATIENT WITH AIDS

Authors

DOI:

https://doi.org/10.11603/1681-2727.2024.1.14414

Keywords:

HIV, Varicella Zoster virus, pemphigus vulgaris

Abstract

SUMMARY. Aim – to describe a case of Ramsay-Hunt syndrome type 2 in a patient with acquired immunodeficiency syndrome. Highlight the features of differential diagnosis and the method of treatment of this syndrome.

After the appearance of vesicles on the skin, the dermatologist prescribed a Tzanck smear test (positive result was obtained). A diagnosis of pemphigus vulgaris was made and was prescribed a combined betamethasone treatment. The use of glucocorticosteroid caused a significant deterioration of the patient’s condition due to the immunosuppressive effect. Cancellation of GCS and usage of Valacyclovir led to healing of skin ulcers, reduction of symptoms of facial paresis and deafness.

Author Biographies

V. V. Vysochanska

Associate Professor at the Microbiology, Virology, Epidemiology and Infectious Diseases Department, Medical Faculty, Uzhhorod National University, Transcarpathian Regional Clinical Infectious Diseases Hospital

I. V. Polyak, Transcarpathian Regional Clinical Infectious Diseases Hospital

infectious diseases doctor, Transcarpathian Regional Clinical Infectious Diseases Hospital

A. I. Kogutych, Uzhhorod National University Transcarpathian Regional Clinical Infectious Diseases Hospital

Associate Professor at the Microbiology, Virology, Epidemiology and Infectious Diseases Department, Medical Faculty, Uzhhorod National University

M. S. Ba­bych, Transcarpathian Regional Clinical Infectious Diseases Hospital

infectious diseases doctor, Transcarpathian Regional Clinical Infectious Diseases Hospital

A. A. Halamba, Uzhhorod National University

PhD, Associate Professor of the Microbiology, Virology, Epidemiology and Infectious Disease Department, Medical Faculty, Uzhhorod National University

References

Jeon, Y., & Lee, H. (2018). Ramsay hunt syndrome. Journal of Dental Anesthesia and Pain Medicine, 18(6), 333-337. DOI: https://doi.org/10.17245/jdapm.2018.18.6.333

Dayan, R. R., & Peleg, R. (2017). Herpes zoster–typical and atypical presentations. Postgraduate Medicine, 129(6), 567-571. DOI: https://doi.org/10.1080/00325481.2017.1335574

Terada, K., Niizuma, T., Kawano, S., Kataoka, N., Akisada, T., & Orita, Y. (1998). Detection of varicella-zoster virus DNA in peripheral mononuclear cells from patients with Ramsay Hunt syndrome or zoster sine herpete. Journal of Medical Virology, 56(4), 359-363. DOI: https://doi.org/10.1002/(SICI)1096-9071(199812)56:4<359::AID-JMV12>3.3.CO;2-0

Yamamoto, T., & Aoyama, Y. (2021). Detection of multinucleated giant cells in differentiated keratinocytes with herpes simplex virus and varicella zoster virus infections by modified Tzanck smear method. The Journal of Dermatology, 48(1), 21-27. DOI: https://doi.org/10.1111/1346-8138.15619

Hussain, M. H., Tanweer, F., Sakagiannis, G., Mair, M., Mahmood, S., & Ashokkumar, S. (2021). Pemphigus vulgaris and bullous pemphigoid of the upper aerodigestive tract: a review article and novel approaches to management. ORL, 83(6), 395-403. DOI: https://doi.org/10.1159/000515229

Egami, S., Yamagami, J., & Amagai, M. (2020). Autoimmune bullous skin diseases, pemphigus and pemphigoid. Journal of Allergy and Clinical Immunology, 145(4), 1031-1047. DOI: https://doi.org/10.1016/j.jaci.2020.02.013

Porro, A. M., Seque, C. A., & Ferreira, M. C. C. (2019). Pemphigus vulgaris. Anais Brasileiros de Dermatologia, 94, 264-278. DOI: https://doi.org/10.1590/abd1806-4841.20199011

Panwar, H., Joshi, D., Goel, G., Asati, D., Majumdar, K., & Kapoor, N. (2017). Diagnostic utility and pitfalls of Tzanck smear cytology in diagnosis of various cutaneous lesions. Journal of Cytology, 34(4), 179. DOI: https://doi.org/10.4103/JOC.JOC_88_16

Gharib, K., Nassar, A., Youssef, A., & Bessar, H. (2023). Dermoscopic approach for differential diagnosing of autoimmune bullous disease: pemphigus vulgaris, pemphigus foliaceus, and IgA pemphigus. International Journal of Dermatology, 62(6), 770-775. DOI: https://doi.org/10.1111/ijd.16623

Zeng, Q., Liu, J., Mu, J., Yang, J., Gao, Q., Wu, F., & Zhou, H. (2023). Optimal biopsy site for the diagnosis of oral pemphigus vulgaris and mucous membrane pemphigoid: a systematic review and meta-analysis. International Journal of Oral and Maxillofacial Surgery. DOI: https://doi.org/10.1016/j.ijom.2023.05.005

Zhao, W., Zhu, H., Zhao, X., Wu, X., Sun, F., Pan, M., & Zhou, S. (2023). Direct Immunofluorescence of IgG on Formalin-Fixed Paraffin-Embedded Tissue by Heat-Induced Antigen Retrieval as a Sensitive Method for the Diagnosis of Pemphigus. Clinical, Cosmetic and Investigational Dermatology, 1233-1241. DOI: https://doi.org/10.2147/CCID.S408613

Published

2024-02-09

How to Cite

Vysochanska, V. V., Polyak, I. V., Kogutych, A. I., Ba­bych, M. S., & Halamba, A. A. (2024). A CLINICAL CASE OF RAMSAY-HUNT SYNDROME TYPE II IN A PATIENT WITH AIDS. Infectious Diseases – Infektsiyni Khvoroby, (1), 55–60. https://doi.org/10.11603/1681-2727.2024.1.14414

Issue

Section

Brief reports