PREVALENCE AND CLINICAL MANIFESTATIONS OF CARDIOVASCULAR SYSTEM LESIONS IN LYME BORRELIOSIS
DOI:
https://doi.org/10.11603/1681-2727.2024.1.14412Keywords:
Lyme disease, Lyme carditis, pathogenesis, prevalence, clinical manifestationsAbstract
SUMMARY. The article provides analyzis of the scientific literature data on the epidemiology and pathogenesis of heart lesions in Lyme borreliosis (LB); the frequency, timing and clinical significance of its cardiological symptoms. The reasons for clinical diagnostics difficulties in Lyme carditis at the current stage are considered as well. It has been proven that in general the relevance of Lyme borreliosis continues to grow in a number of countries, despite the success in treatment, which is due to climatic changes and other factors.
Clinical manifestations of Lyme carditis are diverse, those that occur in the period of early dissemination of the pathogen are described in more detail, in particular, such a potentially life-threatening condition as atrioventricular block. At the same time, there are some reports of no less dangerous heart disorders, such as sick sinus syndrome, sinoatrial block etc, which are usually not in the focus of investigations. A number of LB clinical aspects today require a more in-depth study, in particular, regarding myocarditis and pericarditis of Borrelia etiology, which are often asymptomatic. The least studied are cardiac complications in the chronic stage of LB, about which there are isolated reports in the scientific literature.
Thus, the issue of diagnosis of myocarditis and late cardiac lesions in LB requires further research and development of clear diagnostic criteria. In endemic areas, vigilance is needed regarding the possibility of heart lesions of Borrelia etiology, not only in the case of AV-block, but also in other rhythm and conduction disorders.
References
Osadchyy, O. (2020). Lyme disease: guidelines for treatment and prevention. Ukrayinskyy medychnyy chasopys – Ukrainian medical journal. umj.com.ua. Retrieved from: www.umj.com.ua/uk/publikatsia-195683-hvoroba-lajma-nastanovi-z-likuvannya-ta-profilaktiki [in Ukrainian].
Radesich, C, Del Mestre, E, Medo, K, Vitrella, G, Manca, P, Chiatto, M, Castrichini, M, Sinagra, G. (2022). Lyme Carditis: From Pathophysiology to Clinical Management. Pathogens. 11(5),582. DOI: 10.3390/pathogens11050582. DOI: https://doi.org/10.3390/pathogens11050582
Oscar, J. Rivera, Vinod, Nookala. (2023). Lyme Carditis. Stat Pearls Publishing, Retrieved from www.statpearls.com/point-of-care/24539
Sympascho Young, Omair Arshad, Yasemin Arikan, Yazdan Mirzanejad (2022). Lyme carditis: A can’t miss diagnosis BCMJ, 62 (10), 368-372.
Yeung, C., Baranchuk, A. (2019). Diagnosis and Treatment of Lyme Carditis: JACC Review Topic of the Week. Journal of the American College of Cardiology, 73,(6), 717-726, DOI: 10.1016/j.jacc.2018.11.035 DOI: https://doi.org/10.1016/j.jacc.2018.11.035
Scheffold, N, Herkommer, B, Kandolf, R, May, A E. (2015). Lyme carditis—diagnosis, treatment and prognosis. Dtsch Arztebl Int, 112 (12), 202-208. doi:10.3238/arztebl.2015.0202 DOI: https://doi.org/10.3238/arztebl.2015.0202
Jarne, M., van Hattem, Jan, T. Keijer, Robin, Nijveldt (2015). A man with cardiac Lyme borreliosis. CMAJ, 187(14), 1071-1073. DOI: 10.1503/cmaj.141468 DOI: https://doi.org/10.1503/cmaj.141468
Yarema, N. I., Myndziv, K. V., Kotsiuba, O. I., Popovych, D. V. (2021). Description of a clinical case of Lyme carditis. Achievements in clinical and experimental medicine – Zdobutky klinichnoi i eksperymentalnoi medytsyny, 3, 161-172. DOI: 10.11603/1811-2471.2021.v.i3.12254 [in Ukrainian]. DOI: https://doi.org/10.11603/1811-2471.2021.v.i3.12254
Popovych, O. O. (2016). Lyme-borreliosis: a modern problem of infectology (clinical lecture). Actual infectology – Aktualna infektolohiia, 3(12), 114–122. DOI: 10.22141/2312-413x.3.12.2016.81725 [in Ukrainian]. DOI: https://doi.org/10.22141/2312-413x.3.12.2016.81725
Krause, P. J., Bockenstedt, L. K. (2013). Lyme Disease and the Heart. Circulation. 127(7), 451–454. doi: 10.1161/CIRCULATIONAHA.112.101485
Mukharska, L.M. Yemets, M.A., Biletska, H.V., Lozynskyi, I.M., Semenyshyn, O.B. (2005). Methodological recommendations on epidemiology, diagnosis and prevention of ixodobos tick-borne borreliosis (Lyme disease) in Ukraine. zakononline.com.ua. Retrieved from: https://zakononline.com.ua/documents/show/83937___83937
Linden, Hu (2023). Lime carditis. UpToDate. Retrieved from www.uptodate.com/contents/lyme-carditis?search=lyme%20carditis&source=search_result&selectedTitle=1~17&usage_type=default&display_rank=1
Georgia, Besant, Douglas, Wan, Cynthia, Yeung, Crystal, Blakely, Pamela, Branscombe, Laiden, Suarez-Fuster… Adrian, Baranchuk (2018). Suspicious index in Lyme carditis: Systematic review and proposed new risk score. Clin Cardiol.,41(12),1611–1616. doi: 10.1002/clc.23102 DOI: https://doi.org/10.1002/clc.23102
Dzyga, S.V., Bakalets, O.V., Behosh, N.V., Maksiv, K.Iu. (2020). A clinical case of borreliosis infection as a possible cause of heart damage and occurrence of syncopal states. Bulletin of medical and biological research – Visnyk medychnykh i biolohichnykh doslidzhen, 1, 83-85. DOI: 10.11603/bmbr.2706-6290.2020.1.10959 [in Ukrainian]. DOI: https://doi.org/10.11603/bmbr.2706-6290.2020.1.10959
Goldberg, Nieca (2014). Cardiologists: Know the signs of Lyme disease. Healio. Retrieved from www.healio.com/news/cardiology/20140414/cardiologists-know-the-signs-of-lyme-disease
Krause, P. J., Bockenstedt, L. K. (2013). Lyme disease and the heart. Circulation, 127, 451-454. DOI:org/10.1161/CIRCULATIONAHA.112.101485 DOI: https://doi.org/10.1161/CIRCULATIONAHA.112.101485
Maderis, T. (2021). What is Lyme Carditis? drtoddmaderis.com. Retrieved from: drtoddmaderis.com/what-is-lyme-carditis
Kozlovska, A. (2019). Lyme disease: clinical picture, diagnosis and treatment. Ukrainian medical journal – Ukrainskyi medychnyi chasopys. Retrieved from www.umj.com.ua/article/158253/hvoroba-lajma-klinichna-kartina-diagnostika-ta-likuvannya [in Ukrainian].
Klius, V. Iu. (2017). Multiple organ lesions in Lyme disease. Current infectology – Aktualna infektolohiia, 5 (5), 256-259. DOI: 10.22141/2312-413x.5.5.2017.121642 [in Ukrainian]. DOI: https://doi.org/10.22141/2312-413x.5.5.2017.121642
Muehlenbachs, A, Bollweg BC, Schulz TJ, Forrester, JD., Muehlenbachs, A, Carnes, M…Zaki, Sherif R. (2016). Cardiac tropism of Borrelia burgdorferi: An autopsy study of sudden cardiac death associated with Lyme carditis. The American Journal of Pathology, 186(5), 1195-1205. DOI:10.1016/j.ajpath.2015.12.027 DOI: https://doi.org/10.1016/j.ajpath.2015.12.027
Fish, A.E., Pride, Y.B., Pinto, D.S. (2008). Lyme carditis. Infectious Disease Clinics of North America, 22(2), 275-288. doi: 10.1016/j.idc.2007.12.008 DOI: https://doi.org/10.1016/j.idc.2007.12.008
Lantos, M., Rumbaugh, Jeffrey, Linda, K. Bockenstedt, Yngve, T. Falck-Ytter, Maria, E. Aguero-Rosenfeld, Paul, G. Auwaerter… Lawrence S. Zemel1. (2020). Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. Arthritis Care & Research. 73 (1), 1-9. DOI: 10.1002/acr.24495 DOI: https://doi.org/10.1002/art.41562
Fuster, LS, Gul, EE, Baranchuk, A. (2017). Electrocardiographic progression of acute Lyme disease. The American Journal of Emergency Medicine, 35(7),1040-1040. DOI: 10.1016/j.ajem.2017.02.052 DOI: https://doi.org/10.1016/j.ajem.2017.02.052
Lytvyn, H, Basa, N, Slivinska-Kurchak, K, Avramenko, I. (2022). First-degree atrioventricular block in 14-year-old child due to Lyme disease. J. Infect. Dev. Ctries., 16(4), 726-728. doi: 10.3855/jidc.15071. DOI: https://doi.org/10.3855/jidc.15071
Bamgboje, A, Akintan, FO, Gupta, NM, Kaur, G, Pekler, G, Mushiyev, S. (2021). Lyme Carditis: A Reversible Cause of Acquired Third-Degree AV Block. Am. J. Case Rep., 22, e927885. doi: 10.12659/AJCR.927885. DOI: https://doi.org/10.12659/AJCR.927885
Malik, MB, Baluch, A, Adhikari, S, Adhikari, S, Quraeshi, S, Rao, S (2021). Early Onset Lyme Myopericarditis With Left Ventricular Dysfunction and Mitral Regurgitation. Journal of Investigative Medicine High Impact Case, 9, 1-4. DOI:10.1177/23247096211045267 DOI: https://doi.org/10.1177/23247096211045267
Shushkovska, Yu. Yu., Afanasiuk, O. I. , Matiash, R. V. (2020). Polyorgan lesions in the disease Clinical case of borreliosis myocarditis. Visnyk Vinnytskoho natsionalnoho medychnoho universytetu – Bulletin of Vinnytsia National Medical University, 24 (2), 232-235. DOI:10.31393/reports-vnmedical-2020-24(2)-06 [in Ukrainian]. DOI: https://doi.org/10.31393/reports-vnmedical-2020-24(2)-06
Tomislav, Kostić, Stefan, Momčilović , Zoran, D Perišić , Svetlana, R Apostolović , Jovana, Cvetković, Andriana, Jovanović…Suzana Tasić-Otašević (2017). Manifestations of Lyme carditis. Int. J. Cardiol., 232, 24-32. DOI: 10.1016/j.ijcard.2016.12.169 DOI: https://doi.org/10.1016/j.ijcard.2016.12.169
Shostakovych-Koretska, L. R., Budaeva, I. V., Cherhinets, A. V., Mavrutenkov, V. V., Marchenko, N. E. (2014). Lyme borreliosis: issues of diagnosis and therapy. Actual infectology – Aktualna infektolohiia, 2 (3), 27-31 [in Ukrainian].
Motamed M, Liblik K, Miranda-Arboleda AF, Wamboldt R, Wang CN, Cingolani O, … Baranchuk A. (2022). Disseminated Lyme disease and dilated cardiomyopathy: A systematic review. Trends in Cardiovascular Medicine, 33(8), 531-536. DOI: 10.1016/j.tcm.2022.05.010 DOI: https://doi.org/10.1016/j.tcm.2022.05.010
Public Health Agency of Canada. (2023). Lyme disease: Surveillance. canada.ca. Retrieved from: www.canada.ca/en/public-health/services/diseases/lyme-disease/surveillance-lyme-disease.html.
Audrius, Aurelijus, Pilypas, Jurgita, Valaikiene, Giedrutė, Raišelienė (2019). Lyme disease and heart transplantation: presentation of a clinical case and a literature review. Acta Med. Litu. 26(3),173-180. DOI: 10.6001/actamedica.v26i3.4147. DOI: https://doi.org/10.6001/actamedica.v26i3.4147
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