CHANGES OF INTEGRAL HEMATOLOGICAL INDICATORS IN LEPTOSPIROSIS
DOI:
https://doi.org/10.11603/1681-2727.2023.3.14207Keywords:
leptospirosis, Leptospira interrogans, hematological indexAbstract
SUMMARY. The pathogenesis of leptospirosis is conditioned by a number of factors resulting from endo- and exotoxicosis caused by Leptospira interrogans. To assess the usage of hematological indices as predictors of disease severity, we analyzed integral hematological indices in 56 patients with leptospirosis, who were treated at Lviv Regional Infectious Disease Clinical Hospital in 2016–2019. The specific hematological markers were mathematically calculated using standard formulas. Patients with leptospirosis had a unidirectional character of adaptation markers changes (decreasing of all indices) at the start of the disease, which corresponded to a «stress reaction». In the dynamics of the disease, a tendency towards the normalization of the specified parameters was noted, which corresponded to the «reaction of orientation». These changes ere obviously the result of an increase in the level of granulocytes and a decrease of lymphocytes due to toxemia. An unsatisfactory adaptation state can be considered a risk factor for a severe and complicated course of leptospirosis.
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