EFFICIENCY OF USING THE PROBIOTIC «LACTIALE GERMINA FORTE» IN THE COMPLEX TREATMENT OF PATIENTS WITH COVID-19
DOI:
https://doi.org/10.11603/1681-2727.2023.2.14098Keywords:
COVID-19, intestinal microflora, pro-inflammatory cytokines, probiotic, Bacillus clausii UBBC-07Abstract
SUMMARY. The purpose of the work is to analyze the frequency and spectrum of disorders of the digestive tract in patients with COVID-19 and to evaluate the effectiveness of the use of a probiotic containing B. clausii UBBC-07 spores.
Materials and methods. 85 patients with COVID-19 were examined, of which 59 (69.4 %) had gastrointestinal disorders. They were divided into two groups: group I included 30 (50.9 %) patients who, in addition to standard therapy, were prescribed the probiotic «Lactiale Germina Forte» 1 bottle 2 times a day for 7 days, group II – 29 (49.1 %) of patients who received standard etiotropic and pathogenetic therapy.
Research results. Gastrointestinal disorders in patients with COVID-19 were characterized by decreased or absent appetite, diarrhea, bitterness in the mouth, abdominal pain, nausea, vomiting. Symptoms of TC damage on the 7th day from the start of treatment persisted in 5 (16.7 %) patients of group I and 20 (69.0 %) of patients from group II (р˂0.001). In the representatives of group I, the content of interleukin-1β, interleukin-2, and interleukin-8 decreased dynamically compared to the initial level (р˂0.01), and was lower than the similar indicator in the comparison group (р˂0.05) after treatment. Also, in these patients, there was an increase in the content of bifidobacteria and lactobacilli relative to the significantly reduced initial level (р˂0.001), inhibition of the growth of Staphylococcus aureus (р˂0.001), fungi of the genus Candida (р˂0.01), a decrease in the number of Escherichia coli with reduced enzymatic activity activity (р˂0.001), enterococci (р˂0.001), a tendency to decrease the number of Escherichia coli with hemolytic activity (р˃0.05).
Conclusions. The emergence of digestive tract disorders is typical for COVID-19. The use of «Lactiale Germina Forte» in the complex therapy of patients contributes to the regression of clinical manifestations, normalization or approximation to normalization of the content of pro-inflammatory cytokines in the blood serum, restoration of the state of the intestinal microflora, compared to standard therapy.
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