ASSESSMENT OF THE COMPLETENESS OF REGISTRATION OF TICK INFECTIONS IN TERNOPIL REGION

Authors

DOI:

https://doi.org/10.11603/1681-2727.2023.1.13921

Keywords:

tick-borne infections, Lyme borreliosis, morbidity statistics

Abstract

SUMMARY. The purpose of the study is to assess the completeness of the statistical record of individual tick-borne infections.

Materials and methods. The results of long-term epidemiological surveillance of tick-borne infectious diseases were used, including data from official statistics, epidemiological investigations, field entomological and laboratory studies. Statistical methods of assessment and forecasting are applied.

The results. Manifestations of the epidemic process, clinical course, diagnosis of Lyme borreliosis (LB) in the Ternopil region were evaluated. Incidence indicators in individual districts and their dynamics during 2000-2021 were analyzed. The number of registered cases was compared with predicted statistical methods. The ratio of erythematous (EF) and non-erythematic forms (BEF) of LB was analyzed, territorial differences in diagnosis were revealed. Centrality is determined. The completeness of the record of risk events for Borrelia infection was assessed.

Levels of registered incidence of LB turned out to be lower than predicted. At the same time, the predicted number of undetected patients with BEF LB was higher than the number of undetected cases of EF.

Conclusion. The conducted assessment gives reason to consider the official statistical indicators of the incidence of LB to be lower than the real ones.

Author Biographies

V. O. Panychev, Ternopil Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine

Deputy General Director for Research of Biological Factors of the State institution «Ternopil Regional Center for Disease Control and Prevention of the Ministry of Health of Ukraine»

M. A. Andreychyn, I. Horbachevsky Ternopil National Medical University

academician of NAMS of Ukraine, MD, Professor, Head of the Department of Infectious Diseases and Epidemiology, Skin and Venereal Illnesses of I. Horbachevsky Ternopil National Medical University

A. S. Sverstiuk, I. Horbachevsky Ternopil National Medical University

Doctor of Technical Sciences, Professor of the Department of Medical Informatics of I. Horbachevsky Ternopil National Medical University

References

Bord, S., Dernat, S., Ouillon, L., René-Martellet, M., Vourc’h, G., Lesens, O., ... & Lebert, I. (2022). Tick ecology and Lyme borreliosis prevention: a regional survey of pharmacists’ knowledge in Auvergne-Rhône-Alpes, France. Ticks and Tick-Borne Diseases, 13 (3), 101932. https://doi.org/10.1016/j.ttbdis.2022.101932.

Beltrame, A., Rodari, P., Mauroner, L., Zanella, F., Moro, L., Bertoli, G., ... & Silva, R. (2021). Emergence of Lyme borreliosis in the province of Verona, Northern Italy: Five-years of sentinel surveillance. Ticks and Tick-borne Diseases, 12(2), 101628. https://doi.org/10.1016/j.ttbdis.2020.101628.

Elhelw, R. A., El-Enbaawy, M. I., & Samir, A. (2014). Lyme borreliosis: A neglected zoonosis in Egypt. Acta tropica, 140, 188-192. https://doi.org/10.1016/j.actatropica.2014.09.005. DOI: https://doi.org/10.1016/j.actatropica.2014.09.005

Figoni, J., Chirouze, C., Hansmann, Y., Lemogne, C., Hentgen, V., Saunier, A., ... & Tattevin, P. (2019). Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. Médecine et maladies infectieuses, 49(5), 318-334. https://doi.org/10.1016/j.medmal.2019.05.006.

Tilak, R., Karade, S., Yadav, A. K., Singh, P. M. P., Shahbabu, B., Gupte, M. D., ... & Kaushik, S. K. (2022). Lyme Borreliosis, a public health concern in India: Findings of Borrelia burgdorferi serosurvey from two states. Medical Journal Armed Forces India. https://doi.org/10.1016/j.mjafi.2022.09.001.

Moon, S., Gwack, J., Hwang, K. J., Kwon, D., Kim, S., Noh, Y., ... & Youn, S. K. (2013). Autochthonous lyme borreliosis in humans and ticks in Korea. Osong Public Health and Research Perspectives, 4(1), 52-56. https://doi.org/10.1016/j.phrp.2012.12.001.

Naddaf, S. R., Mahmoudi, A., Ghasemi, A., Rohani, M., Mohammadi, A., Ziapour, S. P., ... & Mostafavi, E. (2020). Infection of hard ticks in the Caspian Sea littoral of Iran with Lyme borreliosis and relapsing fever borreliae. Ticks and tick-borne diseases, 11(6), 101500. https://doi.org/10.1016/j.ttbdis.2020.101500. DOI: https://doi.org/10.1016/j.ttbdis.2020.101500

Shulhan, A. M., Zarichna, O. Z., Lozynskyy, I. M., & Semenyshyn, O. B. (2019). Natural foci of Lyme-borreliosis in Lviv region: results of acarological observations and laboratory diagnostics. Studia Biologica, 13(1), 85-94. https://doi.org/10.30970/sbi.1301.586. DOI: https://doi.org/10.30970/sbi.1301.586

Huk, M. T., & Andreychyn, M. A. (2022). Optimization of the treatment of patients with Lyme borreliosis and human granulocytic anaplasmosis. Bulletin of Medical and Biological Research. Ternopil State Medical University. https://doi.org/10.11603/bmbr.2706-6290.2021.4.12756 [in Ukrainian]. DOI: https://doi.org/10.11603/bmbr.2706-6290.2021.4.12756

Figoni, J., Chirouze, C., Hansmann, Y., Lemogne, C., Hentgen, V., Saunier, A., ... & Tattevin, P. (2019). Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. Médecine et maladies infectieuses, 49(5), 318-334. https://doi.org/10.1016/j.medmal.2019.04.381. DOI: https://doi.org/10.1016/j.medmal.2019.04.381

Cuellar, J., Dub, T., Sane, J., & Hytönen, J. (2020). Seroprevalence of Lyme borreliosis in Finland 50 years ago. Clinical Microbiology and Infection, 26(5), 632-636. https://doi.org/10.1016/j.cmi.2019.10.003. DOI: https://doi.org/10.1016/j.cmi.2019.10.003

Stanek, G., Fingerle, V., Hunfeld, K. P., Jaulhac, B., Kaiser, R., Krause, A., ... & Gray, J. (2011). Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clinical Microbiology and Infection, 17(1), 69-79. https://doi.org/10.1111/j.1469-0691.2010.03175.x. DOI: https://doi.org/10.1111/j.1469-0691.2010.03175.x

Haven, J., Magori, K., & Park, A. W. (2012). Ecological and inhost factors promoting distinct parasite life-history strategies in Lyme borreliosis. Epidemics, 4(3), 152-157. https://doi.org/10.1016/j.epidem.2012.07.001. DOI: https://doi.org/10.1016/j.epidem.2012.07.001

Ni, X. B., Jia, N., Jiang, B. G., Sun, T., Zheng, Y. C., Huo, Q. B., ... & Cao, W. C. (2014). Lyme borreliosis caused by diverse genospecies of Borrelia burgdorferi sensu lato in northeastern China. Clinical Microbiology and Infection, 20(8), 808-814. https://doi.org/10.1111/1469-0691.12532. DOI: https://doi.org/10.1111/1469-0691.12532

Smith, R. P., & Boucher, H. W. (Eds.). (2022). Lyme Disease and the Expanded Spectrum of Blacklegged Tick-Borne Infections. Infectious Disease Clinics Of North America, 36(3). https://doi.org/10.1016/s0891-5520(22)00064-2. DOI: https://doi.org/10.1016/S0891-5520(22)00064-2

Kim, K. T., & Seo, M. G. (2023). Molecular analysis of Rickettsia spp. and related tick-borne pathogens detected in dogs in Korea. Acta Tropica, 243, 106934. https://doi.org/10.1016/b978-0-323-91148-1.00006-x. DOI: https://doi.org/10.1016/j.actatropica.2023.106934

Andreychyn, M. A., Korda M. M., Shkilna M. I., Ivakhiv O. L. (2021). Lyme-borreliosis. Ternopil: TNMU, Ukrmedknyha [in Ukrainian].

Miziara, C. S. M. G., Gelmeti Serrano, V. A., & Yoshinari, N. (2018). Passage of Borrelia burgdorferi through diverse Ixodid hard ticks causes distinct diseases: Lyme borreliosis and Baggio-Yoshinari syndrome. Clinics, 73, 394e. https://doi.org/10.6061/clinics/2018/e394. DOI: https://doi.org/10.6061/clinics/2018/e394

Stanek, G., Wormser, G. P., Gray, J., & Strle, F. (2012). Lyme borreliosis. The Lancet, 379(9814), 461-473. https://doi.org/10.1016/s0140-6736(11)60103-7. DOI: https://doi.org/10.1016/S0140-6736(11)60103-7

British Infection Association. (2011). The epidemiology, prevention, investigation and treatment of Lyme borreliosis in United Kingdom patients: a position statement by the British Infection Association. Journal of Infection, 62(5), 329-338. https://doi.org/10.1016/j.jinf.2011.03.006. DOI: https://doi.org/10.1016/j.jinf.2011.03.006

Rudenko, N., Golovchenko, M., Vancova, M., Clark, K., Grubhoffer, L., & Oliver Jr, J. H. (2016). Isolation of live Borrelia burgdorferi sensu lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis. Clinical microbiology and infection, 22(3), 267-e9. https://doi.org/10.1016/j.cmi.2015.11.009. DOI: https://doi.org/10.1016/j.cmi.2015.11.009

Strle, F., Stupica, D., Bogovič, P., Visintainer, P., & Wormser, G. P. (2018). Is the risk of early neurologic Lyme borreliosis reduced by preferentially treating patients with erythema migrans with doxycycline? Diagnostic Microbiology and Infectious Disease, 91(2), 156–160. https://doi.org/10.1016/j.diagmicrobio.2018.01.025. DOI: https://doi.org/10.1016/j.diagmicrobio.2018.01.025

Kortela, E., Kanerva, M. J., Kurkela, S., Oksi, J., Koivisto, M., & Järvinen, A. (2022). Consumption of healthcare services and antibiotics in patients with presumed disseminated Lyme borreliosis before and after evaluation of an infectious disease specialist. Ticks and Tick-borne Diseases, 13(1), 101854. https://doi.org/10.1016/j.ttbdis.2021.101854. DOI: https://doi.org/10.1016/j.ttbdis.2021.101854

Beltrame, A., Rodari, P., Mauroner, L., Zanella, F., Moro, L., Bertoli, G., Da Re, F., Russo, F., Napoletano, G., & Silva, R. (2021). Emergence of Lyme borreliosis in the province of Verona, Northern Italy: Five-years of sentinel surveillance. Ticks and Tick-borne Diseases, 12(2), 101628. https://doi.org/10.1016/j.ttbdis.2020.101628.

Zanzani, S. A., Rimoldi, S. G., Manfredi, M., Grande, R., Gazzonis, A. L., Merli, S., Olivieri, E., Giacomet, V., Antinori, S., Cislaghi, G., Bestetti, G., Nan, K., Sala, V., Gismondo, M. R., Atzori, C., & De Faveri, E. (2019). Lyme borreliosis incidence in Lombardy, Italy (2000–2015): Spatiotemporal analysis and environmental risk factors. Ticks and Tick-borne Diseases, 10(6), 101257. https://doi.org/10.1016/j.ttbdis.2019.07.001. DOI: https://doi.org/10.1016/j.ttbdis.2019.07.001

Geebelen, L., Van Cauteren, D., Devleesschauwer, B., Moreels, S., Tersago, K., Van Oyen, H., Speybroeck, N., & Lernout, T. (2019). Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015–2017. Ticks and Tick-borne Diseases, 10(3), 598–605. https://doi.org/10.1016/j.ttbdis.2018.12.007.

Hinckley, A. F., Connally, N. P., Meek, J. I., Johnson, B. J., Kemperman, M. M., Feldman, K. A., White, J. L., & Mead, P. S. (2014). Lyme Disease Testing by Large Commercial Laboratories in the United States. Clinical Infectious Diseases, 59(5), 676–681. https://doi.org/10.1093/cid/ciu397. DOI: https://doi.org/10.1093/cid/ciu397

Wijesinghe, S., Walsh, A., Stauffer, J., Hamler, N., Sawh, O. (2023). Intersection of Emerging Infectious Diseases and Substance Use Disorder. Physician Assistant Clinics, 8(3), 593–612. https://doi.org/10.1016/j.cpha.2023.02.009. DOI: https://doi.org/10.1016/j.cpha.2023.02.009

Wilking, H., & Stark, K. (2014). Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany, 2009–2012. Ticks and Tick-borne Diseases, 5(3), 219–224. https://doi.org/10.1016/j.ttbdis.2013.10.010. DOI: https://doi.org/10.1016/j.ttbdis.2013.10.010

Busson, L., Reynders, M., Van den Wijngaert, S., Dahma, H., Decolvenaer, M., Vasseur, L., & Vandenberg, O. (2012). Evaluation of commercial screening tests and blot assays for the diagnosis of Lyme borreliosis. Diagnostic Microbiology and Infectious Disease, 73(3), 246–251. https://doi.org/10.1016/j.diagmicrobio.2012.04.001. DOI: https://doi.org/10.1016/j.diagmicrobio.2012.04.001

Twizeyimana, E., Pichard, E., Lunel-Fabiani, F., Fanello, S., & De Martino, S. J. (2014). Impact of serodiagnosis on the management of Lyme borreliosis at Angers University Hospital. Médecine et Maladies Infectieuses, 44(9), 429–432. https://doi.org/10.1016/j.medmal.2014.07.011. DOI: https://doi.org/10.1016/j.medmal.2014.07.011

Kobayashi, T., & Auwaerter, P. G. (2022). Diagnostic Testing for Lyme Disease. Infectious Disease Clinics of North America, 36(3), 605–620. https://doi.org/10.1016/j.idc.2022.04.001. DOI: https://doi.org/10.1016/j.idc.2022.04.001

Zeman, P., & Benes, C. (2013). Spatial distribution of a population at risk: An important factor for understanding the recent rise in tick-borne diseases (Lyme borreliosis and tick-borne encephalitis in the Czech Republic). Ticks and Tick-borne Diseases, 4(6), 522–530. https://doi.org/10.1016/j.ttbdis.2013.07.003.

Strle, F., & Wormser, G. P. (2022). Early Lyme Disease (Erythema Migrans) and Its Mimics (Southern Tick-Associated Rash Illness and Tick-Associated Rash Illness). Infectious Disease Clinics of North America, 36(3), 523–539. https://doi.org/10.1016/j.idc.2022.03.005. DOI: https://doi.org/10.1016/j.idc.2022.03.005

Baarsma, M. E., van de Schoor, F. R., Gauw, S. A., Vrijmoeth, H. D., Ursinus, J., Goudriaan, N., Popa, C. D., ter Hofstede, H. J., Leeflang, M. M., Kremer, K., van den Wijngaard, C. C., Kullberg, B.-J., Joosten, L. A., & Hovius, J. W. (2022). Diagnostic parameters of cellular tests for Lyme borreliosis in Europe (VICTORY study): a case-control study. The Lancet Infectious Diseases, 22(9), 1388–1396. https://doi.org/10.1016/s1473-3099(22)00205-5. DOI: https://doi.org/10.1016/S1473-3099(22)00205-5

Moon, S., Gwack, J., Hwang, K. J., Kwon, D., Kim, S., Noh, Y., Roh, J., Shin, E., Jeong, K., Seok, W., & Youn, S.-K. (2013). Autochthonous Lyme Borreliosis in Humans and Ticks in Korea. Osong Public Health and Research Perspectives, 4(1), 52–56. https://doi.org/10.1016/j.phrp.2012.12.001. DOI: https://doi.org/10.1016/j.phrp.2012.12.001

Bransfield, R., Embers, M., & Dwork, A. (2023). A Fatal Case of Late Stage Lyme Borreliosis and Substance Abuse. Journal of Affective Disorders Reports 12, 100525. https://doi.org/10.1016/j.jadr.2023.100525. DOI: https://doi.org/10.1016/j.jadr.2023.100525

Bord, S., Dernat, S., Ouillon, L., René-Martellet, M., Vourc’h, G., Lesens, O., Forestier, C., & Lebert, I. (2022). Tick ecology and Lyme borreliosis prevention: a regional survey of pharmacists’ knowledge in Auvergne-Rhône-Alpes, France. Ticks and Tick-borne Diseases, 13(3), 101932. https://doi.org/10.1016/j.ttbdis.2022.101932. DOI: https://doi.org/10.1016/j.ttbdis.2022.101932

Itani, O., Haddad, E., Pitron, V., Pichon, F., & Caumes, E. (2021). Focus on patients receiving long-term antimicrobial treatments for lyme borreliosis: No lyme but mostly mental disorders. Infectious Diseases Now, 51(3), 300–303. https://doi.org/10.1016/j.medmal.2020.10.018. DOI: https://doi.org/10.1016/j.medmal.2020.10.018

Tilak, R., Karade, S., Yadav, A. K., Singh, P. M. P., Shahbabu, B., Gupte, M. D., Bajaj, S., & Kaushik, S. K. (2022). Lyme Borreliosis, a public health concern in India: Findings of Borrelia burgdorferi serosurvey from two states. Medical Journal Armed Forces India, Available online. https://doi.org/10.1016/j.mjafi.2022.09.001. DOI: https://doi.org/10.1016/j.mjafi.2022.09.001

Moniuszko-Malinowska, A., Dunaj, J., Andersson, M. O., Czupryna, P., Zajkowska, J., Guziejko, K., Garkowski, A., Grygorczuk, S., Kondrusik, M., & Pancewicz, S. (2020). Assessment of Anaplasma phagocytophilum presence in early Lyme borreliosis manifested by erythema migrans skin lesions. Travel Medicine and Infectious Disease, 36, 101648. https://doi.org/10.1016/j.tmaid.2020.101648. DOI: https://doi.org/10.1016/j.tmaid.2020.101648

Panychev, V. O. (2020). Тick infection in Тernopil parks. Infectious diseases, 4, 35–40. https://doi.org/10.11603/1681-2727.2020.4.11894. DOI: https://doi.org/10.11603/1681-2727.2020.4.11894

Panychev, V. O., Andreichyn, M. A., Kravchuk, Yu. A., Dautov, A. H., & Dubrovska, A. M. (2021). Infestation of ticks in forest biotopes of Ternopil region. Infectious diseases, 2, 44–52. https://doi.org/10.11603/1681-2727.2021.2.12164. DOI: https://doi.org/10.11603/1681-2727.2021.2.12164

Zeman, P., & Benes, C. (2013). Spatial distribution of a population at risk: An important factor for understanding the recent rise in tick-borne diseases (Lyme borreliosis and tick-borne encephalitis in the Czech Republic). Ticks and Tick-borne Diseases, 4(6), 522–530. https://doi.org/10.1016/j.ttbdis.2013.07.003. DOI: https://doi.org/10.1016/j.ttbdis.2013.07.003

Zinchuk O.M. (2014). Asymptomatic course of Lyme borreliosis in workers of a professional group with a high risk of infection. Infectious diseases, 2, 39–42. https://doi.org/10.11603/1681-2727.2014.2.4041.

Boletska T.O., Chemych M.D. (2014). Epidemiological situation with Lyme borreliosis in Sumy region. Infectious diseases, 3, 82–87. https://doi.org/10.11603/1681-2727.2014.3.3935.

Beltrame, A., Rodari, P., Mauroner, L., Zanella, F., Moro, L., Bertoli, G., Da Re, F., Russo, F., Napoletano, G., & Silva, R. (2021). Emergence of Lyme borreliosis in the province of Verona, Northern Italy: Five-years of sentinel surveillance. Ticks and Tick-borne Diseases, 12(2), 101628. https://doi.org/10.1016/j.ttbdis.2020.101628. DOI: https://doi.org/10.1016/j.ttbdis.2020.101628

Pietikäinen, A., Backman, I., Henningsson, A. J., & Hytönen, J. (2022). Clinical performance and analytical accuracy of a C6 peptide-based point-of-care lateral flow immunoassay in Lyme borreliosis serology. Diagnostic Microbiology and Infectious Disease, 103(1), 115657. https://doi.org/10.1016/j.diagmicrobio.2022.115657. DOI: https://doi.org/10.1016/j.diagmicrobio.2022.115657

Espinazo, F. C., Machado, J. A. Q., Peral, P. M., & Muñoz, M. C. P. (2022). Borreliosis, enfermedad de Lyme y fiebre recurrente. Medicine – Programa de Formación Médica Continuada Acreditado, 13(54), 3157–3162. https://doi.org/10.1016/j.med.2022.04.002. DOI: https://doi.org/10.1016/j.med.2022.04.002

Klouwens, M. J., Salverda, M. L. M., Trentelman, J. J., Ersoz, J. I., Wagemakers, A., Gerritzen, M. J. H., van der Ley, P. A., & Hovius, J. W. (2021). Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis. Vaccine, 39(18), 2561–2567. https://doi.org/10.1016/j.vaccine.2021.03.059. DOI: https://doi.org/10.1016/j.vaccine.2021.03.059

Jaulhac, B., Saunier, A., Caumes, E., Bouiller, K., Gehanno, J. F., Rabaud, C., Perrot, S., Eldin, C., de Broucker, T., Roblot, F., Toubiana, J., Sellal, F., Vuillemet, F., Sordet, C., Fantin, B., Lina, G., Sobas, C., Gocko, X., Figoni, J., … Tattevin, P. (2019). Lyme borreliosis and other tick-borne diseases. Guidelines from the French scientific societies (II). Biological diagnosis, treatment, persistent symptoms after documented or suspected Lyme borreliosis. Médecine et Maladies Infectieuses, 49(5), 335–346. https://doi.org/10.1016/j.medmal.2019.05.001. DOI: https://doi.org/10.1016/j.medmal.2019.05.001

Kortela, E., Kanerva, M., Kurkela, S., Oksi, J., & Järvinen, A. (2021). Suspicion of Lyme borreliosis in patients referred to an infectious diseases clinic: what did the patients really have? Clinical Microbiology and Infection, 27(7), 1022–1028. https://doi.org/10.1016/j.cmi.2020.09.022. DOI: https://doi.org/10.1016/j.cmi.2020.09.022

Geebelen, L., Van Cauteren, D., Devleesschauwer, B., Moreels, S., Tersago, K., Van Oyen, H., Speybroeck, N., & Lernout, T. (2019). Combining primary care surveillance and a meta-analysis to estimate the incidence of the clinical manifestations of Lyme borreliosis in Belgium, 2015–2017. Ticks and Tick-borne Diseases, 10(3), 598–605. https://doi.org/10.1016/j.ttbdis.2018.12.007. DOI: https://doi.org/10.1016/j.ttbdis.2018.12.007

Haddad, E., & Caumes, E. (2019). Experience of three French centers in the management of more than 1,000 patients consulting for presumed Lyme Borreliosis. Médecine et Maladies Infectieuses, 49(6), 481–482. https://doi.org/10.1016/j.medmal.2019.03.006. DOI: https://doi.org/10.1016/j.medmal.2019.03.006

Published

2023-03-29

How to Cite

Panychev, V. O., Andreychyn, M. A., & Sverstiuk, A. S. (2023). ASSESSMENT OF THE COMPLETENESS OF REGISTRATION OF TICK INFECTIONS IN TERNOPIL REGION. Infectious Diseases – Infektsiyni Khvoroby, (1), 18–28. https://doi.org/10.11603/1681-2727.2023.1.13921

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Section

Original investigations