PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-2019 – A NEW CONTEMPORARY CHALLENGE: HISTORICAL ASPECTS, APPROACHES TO DIAGNOSTIC AND TREATMENT

Authors

DOI:

https://doi.org/10.11603/1681-2727.2022.4.13696

Keywords:

pediatric multisystem inflammatory syndrome, COVID-19, children, clinic, diagnosis, treatment

Abstract

Modern data on the history of registration and study of «Pediatric multisystem inflammatory syndrome associated with COVID-19» as a new challenge of modern medicine are described. It is emphasized that this is a new condition that occurs in children after being infected with the coronavirus disease (COVID-19). The main clinical and laboratory signs of this syndrome are given, which are the basis of the criteria for its diagnosis. Approaches to the therapy of the disease in children are outlined and the need for further monitoring of the cardiovascular system of patients who have undergone «Pediatric multisystem inflammatory syndrome associated with COVID-19» is emphasized.

Author Biography

O. V. Usachova, Zaporizhzhia State Medical University

MD, professor, head of the Department of Children’s Infectious Diseases of Zaporizhzhia State Medical University

References

Clinical management of patients with COVID-19 “live” clinical guidelines. (2022). Kyiv: Ministerstvo okhorony zdorovia Ukrainy, Derzhavnyi ekspertnyi tsentr ministerstva okhorony zdorovia Ukrainy, Derzhavna naukova ustanova «Naukovo-praktychnyi tsentr profilaktychnoi i klinichnoi medytsyny» Derzhavnoho upravlinnia spravamy. URL: https://www.dec.gov.ua/wp-content/uploads/2022/08/2022_08_24_kn_covid-19_.pdf [in Ukrainian].

World Health Organization (2020). Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19. Retrieved from: https://www.who.int/news-room/commentaries/detail/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19.

Riphagen, S., Gomez, X., Gonzalez-Martinez, C., Wilkinson, N., & Theocharis, P. (2020). Hyperinflammatory shock in children during COVID-19 pandemic. Lancet (London, England), 395(10237), 1607–1608. https://doi.org/10.1016/S0140-6736(20)31094-1

Royal College of Paediatrics and Child Health (2020). Leading paediatricians publish case definition for illness affecting children during COVID-19. Retrieved from: https://www.rcpch.ac.uk/sites/default/files/2020-05/COVID-19-Paediatric-multisystem-%20inflammatory%20syndrome-20200501.pdf.

Potekhina T. (2020). Kawasaki-like symptoms in children with COVID-19: pediatric multisystem inflammatory syndrome. Dytiachyi likar – Children’s doctor, 2 (71), 21-24. URL: https://d-l.com.ua/en/archive/2020/2%2871%29/pages-21-24/kavasaki-podibni-simptomi-v-ditey-z-covid-pediatrichniy-multisistemniy-zapalniy-sindrom [in Ukrainian].

Royal College of Paediatrics and Child Health (2020). Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS) - guidance for clinicians. Retrieved from: https://www.rcpch.ac.uk/resources/paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19-pims-guidance.

Belot, A., Antona, D., Renolleau, S., Javouhey, E., Hentgen, V., Angoulvant, F., Delacourt, C., Iriart, X., Ovaert, C., Bader-Meunier, B., Kone-Paut, I., & Levy-Bruhl, D. (2020). SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(22), 2001010. https://doi.org/10.2807/1560-7917.ES.2020.25.22.2001010

Verdoni, L., Mazza, A., Gervasoni, A., Martelli, L., Ruggeri, M., Ciuffreda, M., Bonanomi, E., & D’Antiga, L. (2020). An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet (London, England), 395(10239), 1771–1778. https://doi.org/10.1016/S0140-6736(20)31103-X

Raab, Ch. P. (2023). Kawasaki Disease. MSD MANUAL. Professional Version. Retrieved from: https://www.msdmanuals.com/professional/pediatrics/miscellaneous-disorders-in-infants-and-children/kawasaki-disease.

Stasiak, A., Perdas, E., & Smolewska, E. (2022). Risk factors of a severe course of pediatric multi-system inflammatory syndrome temporally associated with COVID-19. European journal of pediatrics, 181(10), 3733–3738. https://doi.org/10.1007/s00431-022-04584-8

Das, B. B., Shakti, D., Ghaleb, S., Akam-Venkata, J., Moskowitz, W. B., Osakwe, O., Weiland, M. D., Arya, S., Gajula, V., & Taylor, M. B. (2023). Racial and Ethnic Disparity in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 in Mississippi, USA. Clinical pediatrics, 62(1), 8–16. https://doi.org/10.1177/00099228221108591

Chen, M. R., Kuo, H. C., Lee, Y. J., Chi, H., Li, S. C., Lee, H. C., & Yang, K. D. (2021). Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children. Frontiers in immunology, 12, 632890. https://doi.org/10.3389/fimmu.2021.632890

Oshlyanska, O.A., Okhotnikova, O.M., Zakharchuk, O.V., Rusak S.O. (2021). Multisystem inflammatory syndrome associated with SARS-Cov-2 infection in children: new disease or syndrome? On the example of a clinical case. Ukrainskyi Revmatolohichnyi zhurnal – Ukrainian Journal of Rheumatology, 84 (2), 1-10. https://doi.org/10.32471/rheumatology.2707-6970.84.16258 [in Ukrainian].

Belay, E. D., Abrams, J., Oster, M. E., Giovanni, J., Pierce, T., Meng, L., Prezzato, E., Balachandran, N., Openshaw, J. J., Rosen, H. E., Kim, M., Richardson, G., Hand, J., Tobin-D’Angelo, M., Wilson, S., Hartley, A., Jones, C., Kolsin, J., Mohamed, H., Colles, Z., … Godfred-Cato, S. (2021). Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic. JAMA pediatrics, 175(8), 837–845. https://doi.org/10.1001/jamapediatrics.2021.0630

Nakaz MOZ Ukrainy «Pro zatverdzhennia protokolu «Nadannia medychnoi dopomohy dlia likuvannia koronavirusnoi khvoroby (COVID 19)» vid 02.04.2020 №762 iz zminamy, vnesenymy vid 22.02.2022 №358.

Usachova, O. V., Konakova, O. V., Silina, Ye. A., Vorobiova, N. V. (2022). Multisystem inflammatory syndrome, probably associated with SARS-CoV-2, complicated by thrombus in the right atrium, in a child. Patolohiya – Patologia, 19(3), 146-153. https://doi.org/10.14739/2310-1237.2022.2.255603 [in Ukrainian].

Published

2023-04-14

How to Cite

Usachova, O. V. (2023). PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-2019 – A NEW CONTEMPORARY CHALLENGE: HISTORICAL ASPECTS, APPROACHES TO DIAGNOSTIC AND TREATMENT. Infectious Diseases – Infektsiyni Khvoroby, (4), 4–9. https://doi.org/10.11603/1681-2727.2022.4.13696

Issue

Section

Editorial