PHARMACOTHERAPY OF INTRA-FETAL PATHOLOGIES

Abstract

SUMMARY. The article considers the main problems of pharmacotherapy of intrauterine fetal pathologies. An active search for the solution has been carried out, making the problem truly scientific, not empirical, and most importantly, accessible to practical clinical medicine. Studies have shown that the most promising method of fetal pharmacotherapy is the injection of pharmacological agents into the amniotic fluid. Mathematical models have been created based on the direct delivery of the pharmacological agents to the fetus, taking into account its gestational age, weight, physiological characteristics and volume of amniotic fluid in a developing pregnancy, which allows us to calculate: the initial dose of a drug to be injected into the amniotic fluid, as well as the dynamics of fetal oral absorption of the drugs. A theoretical base has been developed that allows to make this method of fetal pharmacotherapy universal, enabling it to be put into practice and used in a wide range of fetal pathologies in clinical medicine. The most promising area of this method application nowadays is the therapy of intrauterine fetal infections.