A MODERN VIEW OF THE CAUSATIVE AGENTS SPECIES SPECTRUM OF «CLASSICAL» INFECTIOUS BACTERIAL DISEASES
DOI:
https://doi.org/10.11603/1681-2727.2023.1.13470Keywords:
infections, pathogen, taxonomy, causative agentAbstract
SUMMARY. Modern views on «classical» infectious diseases using the examples of whooping cough, diphtheria, erysipelas and pseudomembranous colitis are presented. The role of molecular genetic methods in the study of bacterial pathogenicity factors, as well as for the taxonomy of infectious disease agents, is considered. The data of recent years, on the basis of which new species of bacteria are included among the causative agents of human infectious diseases, have been analyzed. In particular, the expansion of the range of causative agents of pertussis-like diseases, such as Bordetella holmensii, is being considered. In recent years, the structure of the species Corynebacterium diphtheriae has been revised, and the opinion about the « diphtheriae species complex» has been formed. Examples of the opposite situation are illustrated, when the use of molecular methods made it possible to narrow down the circle of possible pathogens for infections with similar clinical pictures. According to the results of research in recent years, role of pathogens other than Streptococcus pyogenes as causative agents of erysipelas is to discussible. Clostridium difficile is identified as the main etiological agent for pseudomembranous colitis.
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