THE EFFECT OF HERPESVIRUS INFECTION ON THE IMMUNE RESPONSE OF CHILDREN WITH ROTAVIRUS GASTROENTERITIS

Abstract

The aim – to establish features of structure of correlations of indicators of immune response in children with a rotavirus infection (RVI), against their infection with herpesviruses (GV) in different periods of a disease.

Materials and methods. 104 children aged one to three years, patients with moderate and severe intestinal infections of rotavirus etiology were examined. Patients were divided into 2 groups: group 1 – 33 children who did not have a background infection with herpesviruses, group 2 – 71 children who suffered from RVI on the background of latent herpesvirus infection (GVI). A comparative analysis of the correlations between the immune response of patients in both groups (CD3 +, CD4 +, CD8 +, CD16 +, CD22 +, IgA, IgM, IgG, IL 1β, 4, TNFα) in the acute period of the disease and in the period of early convalescence was conducted.

Results. In the acute period of rotavirus infection in both groups, the system-forming indicator with the highest number of connections with other traits was the relative content of CD4 + T-lymphocytes, but the nature and strength of correlations between children of the compared groups are different. In the period of convalescence, not only the nature of the connections and their strength are different, but also the matrix of correlations and system-forming indicators. Thus, in group 1 of children this indicator was the relative content of CD8+ T-lymphocytes, 2 groups – TNFα.

Conclusions. The findings suggest that latent herpesvirus infection alters the correlation matrix of immune response rates in children with rotavirus gastroenteritis throughout the disease. This is the basis for further in-depth study of this issue, in order to find ways to restore a more physiological structure of the correlations of the immune response of these patients at the stage of rehabilitation of these patients.