CORONAVIRUS DISEASE COVID-19 IN PREGNANT WOMEN: RELEVANCE OF THE ISSUE

Authors

  • O. V. Riabokon Zaporizhzhia State Medical University
  • V. V. Cherkaskiy Municipal non-profit enterprise “Regional Infectious Diseases Clinical Hospital” of Zaporizhia Regional Council
  • Yu. Yu. Riabokon Zaporizhzhia State Medical University

DOI:

https://doi.org/10.11603/1681-2727.2021.1.11950

Keywords:

coronavirus disease COVID-19, the pregnant

Abstract

Based on inspection of scientific literature we can see information about current coronavirus disease COVID-19 in pregnant women and influence this infection on the course of pregnancy. Besides, we found out information about perinatal transmission and treatment features. Today we install certain features of clinical and laboratory manifestations of infection SARS-CoV-2 in pregnant women, certainly, we must consider all this things for early diagnosis of the disease and severity assessment COVID-19. What’s more, all pregnant women which are on the second and the third trimester especially need of direct care, because we have information about significant deterioration in the course of infection with rapid progression of acute respiratory failure and multiple organ failure in perinatal or postpartum period. All things considered, we should follow to acting and unified recommendations in own country, when we treat pregnant women with severe or critical current coronavirus disease COVID-19.

Author Biographies

O. V. Riabokon, Zaporizhzhia State Medical University

MD, Professor, Head of the Department of Infectious Diseases, Zaporizhzhia State Medical University

V. V. Cherkaskiy, Municipal non-profit enterprise “Regional Infectious Diseases Clinical Hospital” of Zaporizhia Regional Council

Head of the Department of Anesthesiology and Intensive Care of Municipal non-profit enterprise “Regional Infectious Diseases Clinical Hospital” of Zapo­rizhzhia Regional Council

Yu. Yu. Riabokon, Zaporizhzhia State Medical University

MD, Professor of the Department of Pediatric Infectious Disseases, Zaporizhzhia State Medical University

References

Racicot, K., & Mor, G. (2017). Risks associated with viral infections during pregnancy. J Clin. Invest., 127 (5), 1591-1599. DOI:10.1172/JCI87490

Madjunkov, M., Dviri, M. & Librach, C. (2020). A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective. J. Ovarian Res., 140 (13). Retrieved from: https://doi.org/10.1186/s13048-020-00737-1.

Wong, S.F., Chow, K.M., Leung, T.N., Ng, W.F., Ng, T.K., Shek, C.C., Ng, P.C. et al. (2004). Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome. Am J Obstet. Gynecol., 191(1), 292-297. DOI:https://doi.org/10.1016/j.ajog.2003.11.019.

Pettirosso, E., Giles, M., Cole, S., Rees, M. (2020). COVID-19 and pregnancy: A review of clinical characteristics, obstetric outcomes and vertical transmission. Aust. N Z J Obstet. Gynaecol., 60 (5), 640-659. Retrieved from: https://doi.org/10.1111/ajo.13204.

Adhikari, E.H., Moreno, W., Zofkie, A.C., MacDonald, L., McIntire, D.D., Collins, R.R.J., & Spong, C.Y. (2020). Pregnancy outcomes among women with and without severe acute respiratory syndrome Coronavirus 2 infection. JAMA Netw. Open, 3, 1-11. DOI:10.1001/jamanetworkopen.2020.29256.

Baud, D., Greub, G., Favre, G., Gengler, C., Jaton, K., Dubruc, E., Pomar, L. (2020). Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA, 323 (21), 2198-2200. DOI: 10.1001/jama.2020.7233.

Chen, L., Li, Q., Zheng, D., Jiang, H., Wei, Y., Zou, L., Feng, L., Xiong, G., Sun, G., Wang, H., Zhao, Y., Qiao, J. (2020). Clinical characteristics of pregnant women with Covid-19 in Wuhan, China. N Engl J Med, 323(25), 100. P. 100. DOI:10. 1056/NEJMc2009226.

Yu, N., Li, W., Kang, Q., Xiong, Z., Wang, S., Lin, X., Liu, Y., et al. (2020). Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect. Dis., 20 (5), 559-564. DOI:10.1016/S1473-3099(20)30176-6.

Hantoushzadeh, S., Shamshirsaz, A.A., Aleyasin, A., Seferovic, M.D., Aski, S.K., Arian, S.E.,... Aagaard, K. (2020). Maternal death due to COVID-19. Am. J. Obstet. Gynecol., 223 (1), 109.e1-109.e16. DOI: 10.1016/j.ajog.2020.04.030.

Li, J., Wang, Y., Zeng, Y., Song, T., Pan, X., Jia, M.,… Chen, D. (2020). Critically ill pregnant patient with COVID-19 and neonatal death within two hours of birth. Int. J. Gynaecol. Obstet., 150, 126-128. DOI: 10.1002/ijgo.13189.

Alzamora, M.C., Paredes, T., Caceres, D., Webb, C.M., Valdez, L.M., & Rosa, M.L. (2020). COVID-19 during pregnancy and possible vertical transmission. Am. J. Perinatol, 37, 861-865. DOI: 10.1055/s-0040-1710050.

Vallejo, V., & Ilagan, J.G. (2020). A postpartum death due to Coronavirus disease 2019 (COVID-19) in the United States. Obstet. Gynecol., 136 (1), 52-55. DOI: 10.1097/AOG.0000000000003950.

Sutton, D., Fuchs, K., D’Alton, M., & Goffman, D. (2020). Universal screening for SARS-CoV-2 in women admitted for delivery. N. Engl. J. Med., 382 (22), 2163-2164. DOI: 10.1056/NEJMc2009316.

Yan, J., Guo, J., Fan, C., Juan, J., Yu, X., Li, J. … Yang, H. (2020). Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am. J. Obstet. Gynecol., 223 (1), 111.e1-111.e14. DOI: 10.1016/j.ajog.2020.04.014.

Liu, D., Li, L., & Wu, X. (2020). Pregnancy and perinatal outcomes of women with coronavirus disease (COVID-19) pneumonia: a preliminary analysis. Am. J. Roentgenol., 215 (1), 127-132. DOI: 10.2214/AJR.20.23072.

Dashraath, P., Wong, J.L.J., Lim, M.X.K., Lim, L.M., Li, S., Biswas, A. … Su, L.L. (2020). Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am. J. Obstet. Gynecol., 22(6), 521-531. DOI: 10.1016/j.ajog.2020.03.021.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., … Cao, P.B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet, 395, 1054-1062. DOI: 10.1016/S0140-6736(20)30566-3.

Kovac, M., Mikovic, Z., Rakicevic, L., Srzentic, S., Mandic, V., Djordjevic, V., Radojkovic, D., & Elezovic, I. (2020). The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. Eur. J. Obstet. Gynecol. Reprod. Biol., 148 (1), 27-30. DOI: 10.1016/j.ejogrb.2009.09.005.

Allotey, J., Stallings, E., Bonet M., Yap, M., Chatterjee, S., Kew, T., … Thangaratinam, S. (2020). Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ, 370, m3320. DOI: https://doi.org/10.1136/bmj.m3320.

Cohen, J., Vignaux, O., & Jacquemard, F. (2020). Covid-19 in pregnant women: General data from a French National Survey. Eur. J. Obstet. Gynecol. Reprod. Biol., 251 (9), 267-268. DOI:10.1016/j.ejogrb.2020.06.002 pmid:32540156.

Ellington, S., Strid, P., Tong, V.T., Woodworth, K., Galang, R.R., Zambrano, L.D., … Gilboa, S.M. (2020). Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status – United States. MMWR Morb. Mortal. Wkly. Rep., 69 (25), 769-775. DOI: 10.15585/mmwr.mm6925a1.

Huntley, B.J.H., Huntley, E.S., Mascio, D.D., Chen, T., Berghella, V., Chauhan, S.P. (2020). Rates of maternal and perinatal mortality and vertical transmission in pregnancies complicated by severe acute respiratory syndrome coronavirus 2 (SARS-co-V-2) infection: a systematic review. Obstet. Gynecol., 136 (2), 303-312. DOI: 10.1097/AOG.0000000000004010.

Khoury, R., Bernstein, P.S., Debolt, C., Stone, J., Sutton, D.M., Simpson, L.L. … M Dolan S.M. (2020). Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection at five New York city medical centers. Obstet. Gynecol, 136 (2), 273-282. DOI: 10.1097/AOG.0000000000004025.

Algarroba, G.N., Rekawek, P., Vahanian, S.A., Khullar, P., Palaia, T., Peltier, M.R., Chavez, M.R., & Vintzileos, A.M. (2020). Visualization of SARS-CoV-2 virus invading the human placenta using electron microscopy. Vahanian Am. J. Obstet. Gynecol., 232 (2), 275-278. DOI: 10.1016/j.ajog.2020.05.023.

Patanè, L., Morotti, D., Giunta, M.R., Sigismondi, C., Piccoli, M.G., Frigerio, L., … Cornolti, G. (2020). Vertical transmission of COVID19: SARS-CoV-2 RNA on the fetal side of the placenta in pregnancies with COVID-19 positive mothers and neonates at birth. Am. J. Obstet. Gynecol., 2(3). DOI: 10.1016/j.ajogmf.2020.100145.

Thea, N.G., & Rebecca, A. (2020). Simmons maternal and neonatal response to COVID-19. Am. J. Physiol. Endocrinol. Metab., 319 (2), 315-319. DOI: 10.1152 / ajpendo.00287.2020.

Li, M., Chen, L., Zhang, J., Xiong, C., & Li, X. (2020). The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One, 15 (4). DOI:10.1371/journal. pone.0230295.

Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., & Erichsen, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitorc. Cell, 181 (2), 271-280. DOI: 10.1016/j.cell.2020.02.052.

Sungnak, W., Huang, N., Bécavin, C., Berg, M., Queen, R., Litvinukova, M. … Josephine L Barnes, J.L. (2020). SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat. Med. 26 (5), 681-687. DOI:10.1038/s41591- 020-0868-6.

Yoon, S.H., Kang, J.-M., & Ahn, J.G. (2020). Ahn Clinical outcomes of 201 neonates born to mothers with COVID-19: a systematic review. Eur. Rev. Med. Pharmacol. Sci., 24 (14). DOI: 10.26355/eurrev_202007_22285.

Kotlyar, M.A., Grechukhina, O., Chen, A., Popkhadze, S., Grimshaw, A., Tal, O., Taylor, H.S., & Tal, R. (2020). Vertical transmission of COVID-19: a systematic review and Meta-analysis. Am. J. Obstet. Gynecol., 224 (1), 35-53. DOI: https://doi.org/10.1016/j.ajog.2020.07.049.

Pique-Regi, R., Romero, R, Tarca, A.L., Luca, F., Xu, Y., Alazizi, A., Leng, Y., Hsu, C-D., Gomez-Lopez, N. Does the human placenta express the canonical cell entry mediators for SARS-CoV-2? Elife, 9. DOI: 10.7554/eLife.58716.

National Institutes of Health (2020). Coronavirus disease 2019 (COVID-19) treatment guidelines. COVID-19 Treatment Guidelines Panel. Retrieved from: https://www.covid19treatmentguidelines.nih.gov/.

Order of the Ministry of Health of Ukraine of April 2, 2020 No. 762, as amended by the order of the Ministry of Health of December 31, 2020 № 3094 Protocol «Provision of medical care for the treatment of coronavirus disease (COVID-19)» [in Ukrainian].

Tolcher, M.C., McKinney, J.R., Eppes, C.S., Muigai, D., Shamshirsaz, A., Guntupalli, K.K., & Nates, J.L. (2020). Prone positioning for pregnant women with hypoxemia due to coronavirus disease 2019 (COVID-19). Obstet. Gynecol., 136 (2), 259-261. DOI:10.1097/AOG.0000000000004012.

Liang, H., & Acharya, G. (2020). Novel corona virus disease (COVID-19) in pregnancy: What clinical recommendations to follow? Acta Obstet. Gynecol. Scand., 99 (4), 439-442. DOI: 10.1111/aogs.13836.

Naqvi, M., Zakowski, P., Glucksman, L., Smithson, S., & Burwick, R.M. (2020). Tocilizumab and Remdesivir in a pregnant patient with Coronavirus disease 2019 (COVID-19). Obstet. Gynecol., 136 (5), 1025-1029. DOI: 10.1097/AOG.0000000000004050.

Pierce-Williams, R.A.M., Burd, J., Felder, L., Khoury, R., Bernstein, P.S., Avila, K. … Berghella, V. (2020). Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a United States cohort study. Am. J. Obstet. Gynecol. MFM, 2 (3). DOI: 10.1016/j.ajogmf.2020.100134.

Wei, S-Q., Fraser, W., & Luo, Z-C. (2010). Inflammatory cytokines and spontaneous preterm birth in asymptomatic women: a systematic review. Obstet. Gynecol., 116 (2 Pt 1), 393-401. DOI: 10.1097/AOG.0b013e3181e6dbc0.

Horby, P., Lim, W.S., & Emberson, J. (2020). Dexamethasone for COVID-19-Preliminary Report Effect of Dexamethasone in Hospitalized Patients with COVID-19-Preliminary. Report RECOVERY Collaborative Group, 22. DOI: 10.1101/2020.06.22.20137273. 2020.06.22.20137273.

Marim, F., Karadogan, D., Eyuboglu, T.S., Emiralioglu, N., Gurkan, C.G., Toreyin, Z.N. … Akgun, M. (2020). Lessons Learned so Far from the Pandemic: A Review on Pregnants and Neonates with COVID-19. Eurasian J. Med., 52 (2), 202-210. DOI: 10.5152/eurasianjmed.2020.20118.

Published

2021-04-13

How to Cite

Riabokon, O. V., Cherkaskiy, V. V., & Riabokon, Y. Y. (2021). CORONAVIRUS DISEASE COVID-19 IN PREGNANT WOMEN: RELEVANCE OF THE ISSUE. Infectious Diseases – Infektsiyni Khvoroby, (1), 45–52. https://doi.org/10.11603/1681-2727.2021.1.11950

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Section

Reviews and lectures