POST-COVID-19 SYNDROME IS A NEW ACTUAL PROBLEM OF MODERN MEDICINE
DOI:
https://doi.org/10.11603/1681-2727.2020.4.11890Keywords:
coronaviral disease, COVID-19, ‘‘long-haulers’’, post-COVID syndromeAbstract
Coronaviral disease is a challenge to the health care system of many countries due to its high prevalence, the involvement of large numbers of people, the severity disease in certain groups of patients, and the presence of residual symptoms for a long time. Based on reviews, the concept of «post-covid syndrome», its prevalence and main clinical manifestations are highlighted. The pathogenesis of long-term symptoms in patients who have overcome the acute phase are still uncertain, but the hypotheses concern the long-term viral persistence, the hyperinflammatory response in the acute phase, and the development of immunodeficiency. Diagnosis of post-cognitive syndrome involves differential diagnosis with anaemia, vitamin deficiency, and endocrine disorders. The article is addressed mainly to general practitioners who provide outpatient care to COVID-19 convalescents.
References
Garg, P., Arora, U., Kumar, A., & Wig, N. (2021). The “post-COVID” syndrome: How deep is the damage? Journal of Medical Virology, 93 (2), 673-674.
Carfì, A., Bernabei, R., & Landi, F. (2020). Persistent symptoms in patients after acute COVID-19. Jama, 324 (6), 603-605.
Huang, C., Huang, L., Wang, Y., Li, X., Ren, L., Gu, X., ... & Cao, B. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet.
Komaroff, A. (2020). The tragedy of the post-COVID “long haulers”. Harvard Health Letter, OCTOBER 15.
NICE guideline COVID-19 rapid guideline: managing the long-term effects of COVID-19 (www.nice.org.uk/guidance/NG188)
Otte, M. S., Klussmann, J.P., & Luers, J.C. (2020). Persisting olfactory dysfunction in patients after recovering from COVID-19. The Journal of Infection.
Zhao, Y. M., Shang, Y. M., Song, W. B., Li, Q. Q., Xie, H., Xu, Q. F., ... & Xu, A. G. (2020). Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine, 25, 100463.
Tansey, C.M., Louie, M., Loeb, M., Gold, W.L., Muller, M.P., de Jager, J., ... & Herridge, M.S. (2007). One-year outcomes and health care utilization in survivors of severe acute respiratory syndrome. Archives of Internal Medicine, 167 (12), 1312-1320.
Mason, R. J. (2020). Pathogenesis of COVID-19 from a cell biology perspective.
Baig, A. M. (2020). Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome. ACS Chemical Neuroscience. (https://doi.org/10.1021/acschemneuro.0c00725)
Romero-Sánchez, C.M., Díaz-Maroto, I., Fernández-Díaz, E., Sánchez-Larsen, Á., Layos-Romero, A., García-García, J., ... & Segura, T. (2020). Neurologic manifestations in hospitalized patients with COVID-19: the ALBACOVID registry. Neurology, 95 (8), e1060-e1070.
Davido, B., Seang, S., Tubiana, R., & de Truchis, P. (2020). Post-COVID-19 chronic symptoms: a postinfectious entity? Clinical Microbiology and Infection, 26 (11), 1448-1449.
Chen, M., Zhou, W., & Xu, W. (2020). Thyroid function analysis in 50 patients with COVID-19: a retrospective study. Thyroid.
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