Fatal case of generalized chickenpox in an HIV-infected child (clinical and pathological analysis)
DOI:
https://doi.org/10.11603/1681-2727.2021.1.11881Keywords:
child, HIV, Varicella Zoster virus, pneumonia, pathomorphologyAbstract
Summary.
Chickenpox is one of the highly contagious acute infectious diseases with severe course of the disease, which can be complicated with the involvement of the visceral organs and the central nervous system. In HIV-infected children life-threatening conditions can be developed. The case presents a severe form of generalized chickenpox with development of the pneumonia and acute distress syndrome which is described in an 11-year-old HIV-positive child. Simultaneous lack of prior antiretroviral therapy, concealment of the child's HIV status, late request for medical help and many factors were seen. Delayed adequate specific treatment led to a dramatic lethal course of the disease. The course of the disease is due to the child's HIV status and lack of antiretroviral therapy, which led to death.
Conclusion. Postmortem examination confirmed VZV infection with alterative changes in internal organs and morphological changes in lymph nodes typical to HIV infection.
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