PECULIARITIES OF HEMOSTASIS DISORDERS IN PATIENTS WITH CORONAVIRUS INFECTION
DOI:
https://doi.org/10.11603/1681-2727.2020.3.11549Keywords:
hemostasis system, comorbid conditions, thrombohemorrhagic syndrome, coagulopathy, coronavirusAbstract
The aim of the work – to analyze the features of hemostasis disorders in patients with coronavirus infection.
Materials and methods. 78 medical records of inpatients hospitalized in the Regional Clinical Infectious Diseases Hospital of Kharkiv for the period from May to September 2020 were analyzed. To assess the state of the hemostasis system and the risk of thrombohemorrhagic complications, the level of platelets, fibrinogen, D-dimer, active partial thromboplastic time (APTT), international normalized ratio (INR) was monitored.
Results. During the study, disorders of cellular and plasma indicators of hemostasis were analyzed. Patients were divided into groups, depending on the severity of respiratory failure. Coagulation tests were monitored every 48 hours.
Conclusion. In patients with moderate severity, disorders of the hemostasis system in the form of hypercoagulation prevailed. Prolonged course of the disease for more than 21 days or in patients with severe, extremely severe course, hypercoagulation changed to hypocoagulation and DIC syndrome occurred. There is a direct relationship with the state of hemostasis and the severity of coronavirus infection.
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