THE RECOVERY OF VAGINAL MICROBIOM IN BACTERIAL VAGINOSIS BY DIALAC PROBIOTICS
DOI:
https://doi.org/10.11603/1681-2727.2020.4.11460Keywords:
bacterial vaginosis, vaginal microbiome, probiotic, lactobacilli, aerobic and anaerobic pathogens, commensalsAbstract
The article presents the results of study of the vagina microbiome in women with bacterial vaginosis before and after oral use of the capsule form of the probiotic “Dialak” containing strain L. casei IMB B-7280 and vaginal suppositories with the same probiotic. This drug is recommended for the correction of vaginal microbiota, and it has combined anti-inflammatory and selective antimicrobial activity. It has a high antagonistic activity against pathogenic and opportunistic microorganisms: Staphylococcus spp, Streptococcus spp, Pseudomonads spp., Escherichia coli, etc. It effectively inhibits the growth of microscopic fungi.
The aim of the study – to evaluate the effectiveness of the probiotic “Dialak” for women with bacterial vaginosis.
Patients and methods. The examination of women with bacterial vaginosis was performed by traditional gynecological examination to determine the general history of disease particularly, to determine the frequency, severity of clinical manifestations, and duration of recurrence of urogenital infection. Laboratory diagnostic methods included microscopy of the smears for evaluation microbial status for confirmation of the presense of key cells, as well aminotest, examination of secrets pH, classical bacteriological technique before treatment in 10 days after treatment, examination of peripheral blood before treatment and in a month after probiotic therapy to study cellular immunity.
Results. Examination showed that due to vaginal and oral use of probiotic “Dialak” there is stable colonization of vaginal mucosa with commensal microbiota. The effectiveness of the drug against Gardnerella vaginalis, Mobiluncus spp, Lactococcus spp, Veillonella spp is clinically proven.
Conclusion. The possibility of using the probiotic “Dialak” containing strain L. casei IMB B-7280 for the treatment of bacterial vaginosis has been clinically proven. Good tolerability of the medicine, absence of side effects, convenient form of use, justify its use both in obstetrics and gynecology for the treatment of bacterial vaginosis and correction of vaginal micropbiota.
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