TEST FOR CORONAVIRUS – WHAT DOES IT REALLY MEANS FOR THE PATIENT?
DOI:
https://doi.org/10.11603/1681-2727.2020.2.11287Keywords:
coronavirus, SARS-Cov-2, nCov19, detection, tests, PCR, ELISA, IgM, IgG, IgAAbstract
Testing for COVID has become one of the common day activities during pandemic days, often like a visit to dentist or family doctor. However, there are many types of tests with different principles, sensitivities, specificities, and diagnostic windows. And since the COVID disease has a great impact on our social life, changing our behavior, social contacts, and attitude, the incorrect treatment of «test for COVID» can have deteriorating results. The «COVID test» is seldom interpreted correctly due to multiple technologies, ways of testing, sensitivities and even influence of social media. Here we in a simple form summarize the most common detection methods with their peculiarities in the form of Q&A which typical patients can have. We discuss RT-qPCR, POC express tests, ELISA testing for IgG, IgM antibodies, as well as present our data regarding the longevity of blood antibody titers against coronaviral antigens.
References
Bilyy, R., Paryzhak, S., Turcheniuk, K., Dumych, T., Barras, A., Boukherroub, R., … Szunerits, S. (2019). Aluminum oxide nanowires as safe and effective adjuvants for next-generation vaccines. Materials Today, 22, 58-66. DOI:10.1016/j.mattod.2018.10.034
Narasaraju, T., Tang, B.M., Herrmann, M., Muller, S., Chow, V.T.K., & Radic, M. (2020). Neutrophilia and NETopathy as key pathologic drivers of progressive lung impairment in patients with COVID-19. Frontiers in Pharmacology, 11. DOI:10.3389/fphar.2020.00870
Backer, J.A., Klinkenberg, D., & Wallinga, J. (2020). Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020. Eurosurveillance, 25 (5). DOI:10.2807/1560-7917.ES.2020.25.5.2000062
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., … Peng, Z. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel Coronavirus–infected pneumonia in Wuhan, China. JAMA, 323 (11), 1061. DOI:10.1001/jama.2020.1585
Lippi, G., Simundic, A.-M., & Plebani, M. (2020). Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). Clinical Chemistry and Laboratory Medicine (CCLM), 58 (7), 1070-1076. DOI:10.1515/cclm-2020-0285
Young, B.E., Ong, S.W.X., Kalimuddin, S., Low, J.G., Tan, S.Y., Loh, J., … Lye, D.C. (2020). Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA, 323 (15), 1488. DOI:10.1001/jama.2020.3204
Long, Q.-X., Liu, B.-Z., Deng, H.-J., Wu, G.-C., Deng, K., Chen, Y.-K., … Huang, A.-L. (2020). Antibody responses to SARS-CoV-2 in patients with COVID-19. Nature Medicine. DOI:10.1038/s41591-020-0897-1
Xiao, A.T., Gao, C., & Zhang, S. (2020). Profile of specific antibodies to SARS-CoV-2: The first report. Journal of Infection, 81 (1), 147-178. DOI:10.1016/j.jinf.2020.03.012
Yu, H., Sun, B., Fang, Z., Zhao, J., Liu, X., Li, Y., … Zhong, N. (2020). Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients. European Respiratory Journal, 2001526. DOI:10.1183/13993003.01526-2020
Huang, A.T., Garcia-Carreras, B., Hitchings, M.D.T., Yang, B., Katzelnick, L., Rattigan, S.M., … Cummings, D.A.T. (2020). A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease. Med.Rxiv., 2020.04.14.20065771. DOI:10.1101/2020.04.14.20065771
Downloads
Published
How to Cite
Issue
Section
License
Journal Infectious Disease (Infektsiini Khvoroby) allows the author(s) to hold the copyright without registration
Users can use, reuse and build upon the material published in the journal but only for non-commercial purposes
This journal is available through Creative Commons (CC) License BY-NC "Attribution-NonCommercial" 4.0