CLINICAL AND LABORATORY FEATURES OF CIRRHOSIS OF THE LIVER ASSOCIATED WITH HEPATITIS VIRUSES
DOI:
https://doi.org/10.11603/1681-2727.2020.3.11251Keywords:
HCV infection, cirrhosis, fibrotest, liver ultrasoundAbstract
HCV infection is one of the leading causes of chronic liver disease worldwide, cirrhosis is a dangerous complication of chronic liver disease, summarizing a number of progressive stages. Beginning of the disease is latent and manifests itself in nonspecific symptoms, up to the manifestation of significant liver dysfunction.
The aim of the work is to investigate the clinical and laboratory features of liver cirrhosis associated with hepatitis viruses.
Materials and methods. Inpatient medical records were analyzed and 107 patients aged (47.1±12.1) years who were treated at the municipal non-commercial enterprise of Sumy Regional Council “Medical Clinical Center of Infectious Diseases and Dermatology named after Z. Y. Krasovytskyi” and Sumy Regional Clinical Hospital in 2015–2019 were examined. Patients were divided into 2 groups – cirrhosis associated with hepatitis viruses (I) and cirrhosis of non-viral origin (II). Clinical data and blood biochemical parameters were compared with a comparison group of 70 healthy individuals aged (45.6±2.1) years. These studies were processed by the method of variation statistics.
Results. The viral origin of cirrhosis is dominated by middle-aged, overweight male residents of the city. Despite the predominance of minimal activity and severity of class A and B cirrhosis (according to Child Pugh), noninvasive tests indicated a higher number of patients with severe fibrosis in this disease. Medical manipulations and injecting drug use are the most common routes of infection. Astheno-vegetative syndrome, heaviness in the right hypochondrium, subicteric sclera, splenomegaly, encephalopathy, among the concomitant diseases – cholecystitis, metabolic cardiomyopathy dominate. The disease is accompanied by severe thrombocytopenia, accelerated ESR, bilirubinemia and transferasemia, increased echogenicity of the liver and enlargement of the splenic vein.
Conclusion. Cirrhosis associated with hepatitis viruses has a more severe course, pronounced clinical and laboratory symptoms with a predominance of fibrosis, requires a comprehensive examination and constant monitoring.
References
Fortea, J.I., Carrera, I.G., Puente, A., & Crespo, J. (2020). Hepatic cirrhosis. Medicine (Spain), 13 (6), 297-307.
Conde, I., Vinaixa, C., & Berenguer, M. (2017). Hepatitis C-related cirrhosis. Current status. Medicina Clinica, 148 (2), 78-85. DOI: https://doi.org/10.1016/j.medcli.2016.09.019
Mihai, F., Trifan A., Stanciu C., Singeap A.M., Cucuteanu, B., Ursulescu C.L., … Cojocariu, C. (2020). Liver remodeling on ct examination in patients with hcv compensated cirrhosis who achieved sustained virological response after direct-acting antivirals treatment. Medicina (Lithuania), 56 (4). DOI: https://doi.org/10.3390/medicina56040171
Ferenci, P. (2020). Are all cirrhotic patients equal? Journal of Hepatology, 72(3), 389-390. DOI:10.1016/j.jhep.2019.10.022. DOI: https://doi.org/10.1016/j.jhep.2019.10.022
Bhatti, H.W., Tahir, U., Chaudhary, N.A., Bhatti, S., Hafeez, M., & Rizvi, Z.A. (2019). Factors associated with renal dysfunction in hepatitis C-related cirrhosis and its correlation with child-pugh score. BMJ Open Gastroenterology, 6 (1) DOI:10.1136/bmjgast-2019-000286. DOI: https://doi.org/10.1136/bmjgast-2019-000286
Siregar, G.A., & Gurning, M. (2018). Renal dysfunction in liver cirrhosis and its correlation with Child-Pugh score and MELD score. IOP Conf. Ser. Earth Environ. Sci. DOI: https://doi.org/10.1088/1755-1315/125/1/012214
Duah, A., Nkrumah, K.N., & Tachi, K. (2018). Oesophageal varices in patients with liver cirrhosis attending a major tertiary hospital in Ghana. Pan African Medical Journal, 31. DOI: https://doi.org/10.11604/pamj.2018.31.230.16657
Tapper, E.B., Aberasturi, D., Zhao, Z., Hsu, C., & Parikh, N.D. (2020). Outcomes after hepatic encephalopathy in population-based cohorts of patients with cirrhosis. Alimentary Pharmacology and Therapeutics, 51 (12), 1397-1405. DOI:10.1111/apt.15749. DOI: https://doi.org/10.1111/apt.15749
Strauss, E. (2018). Chronic hepatitis C is still a problem for the public health care system in brazil. Arquivos De Gastroenterologia, 55 (4), 321-323. DOI:10.1590/s0004-2803.201800000-90. DOI: https://doi.org/10.1590/s0004-2803.201800000-90
Mansour, D., & McPherson, S. (2018). Management of decompensated cirrhosis. Clinical Medicine. Journal of the Royal College of Physicians of London, 18, s60-s65. DOI:10.7861/clinmedicine.18-2-s60. DOI: https://doi.org/10.7861/clinmedicine.18-2-s60
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