INFLUENCE OF STREPTOCOCCUS OF THE MUCOUS MEMBRANE OF THE NASOPHARYNX ON THE CYTOKINE RESPONSE OF CHILDREN WITH INFECTIOUS MONONUCLEOSIS
DOI:
https://doi.org/10.11603/1681-2727.2019.3.10633Keywords:
children, infectious mononucleosis, clinic, streptococcus, immunityAbstract
The aim of the study – to determine the value of the presence of streptococcus in the nasal and oropharyngeal mucosa in the blood interleukins of children with MI.
Patients and methods. The study included 60 children aged three to seven years, patients with mononucleosis who were hospitalized at Kharkiv Regional Children’s Infectious Clinical Hospital. The diagnosis of mononucleosis was confirmed on the basis of positive results of the search for disease markers by ELISA and PCR. In 30 children (group 1), bacterial examination of the nasal and oropharyngeal mucosa isolated Streptococcus pyogenes in concentrations of 10-5 and above. The group 2 (30 children) was not detected on the nasal and oropharyngeal mucosa. The immune status of patients was assessed by the levels of interleukins 1β, 4, TNF. Determination of the content of interleukins in the blood of patients with mononucleosis of children was carried out in the acute period (1-2 days of the disease) and in the period of early convalescence (7–10 days).
Results and conclusions. Analysis of the results of the survey found that the presence of streptococcus patients with mucous membrane of the nasal and oropharynx in the acute period of infectious mononucleosis leads to a more pronounced reaction of proinflammatory interleukins of their blood and – inhibition of the response of anti-inflammatory interleukin 4 (P <0.05). In the future – there is a slow decrease in the levels of interleukin 1, TNF-α and inhibition of the increase in the content of IL-4.
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