DYNAMICS OF BIOCHEMICAL PARAMETERS, IL-4 AND IL-6 IN PATIENTS WITH ACUTE BRUCELLOSIS BEFORE AND AFTER TREATMENT
DOI:
https://doi.org/10.11603/1681-2727.2019.2.10323Keywords:
acute brucellosis, ALT, AST, IL-4, IL-6Abstract
Brucellosis remains a global problem for many countries around the world. The aim of our study was to determine the dynamics of serum levels of IL-4 and IL-6 in the patients with acute brucellosis before and after treatment.
Materials and methods. We examined 178 patients with clinic signs of acute brucellosis who applied for medical assistance. Specific methods of the study were conducted by ELISA with the detection of IgM and IgG. From 178 surveyed patients, only 120 persons were included in the main group according to the criteria. The control group consisted of 30 practically healthy persons. Among the surveyed, men were in the majority – 75.0 %. The average age of the patients with brucellosis was (35.9±2.8) years.
Results and discussion. Among the patients with acute brucellosis, the most commonly observed were such clinical symptoms: fever – 86.7 %, general weakness – 87.5 %, sweating in 70.0 % of patients, and arthralgia in 64.2 % of patients. At the same time, the least of all patients indicated the presence of myalgia – in 35.0 % of patients and weight loss – in 25.8 % of patients. In the objective survey, it was found that 77.5 % of patients had certain problems of the cardiovascular system, whereas only one patient (0.8 %) had disorders of the sexual system in the form of orchitis. A reliable difference was found between the overall blood count and the biochemical parameters among the main group before and after treatment and healthy individuals. It was found that the level of IL-4 in the serum of patients with acute brucellosis before treatment was (11.3±0.7) and the level of IL-6 was (15.3±1.4) pg/ml versus (15.3±1,4) and (8.5±0.9) pg/ml after therapy, respectively.
Conclusions. The level of hemoglobin in patients with acute brucellosis was 1.2 times lower compared with the control group. The levels of ALT and AST before treatment were 1.7 and 1.9 times higher, respectively, compared to post-treatment and 1.9 and 2.5 times higher compared to control group. IL-4 and IL-6 levels were 1.6 and 1.8 times higher in patients with acute brucellosis before and after treatment, and 1.8 and 2.0 times higher than healthy subjects.
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