OXIDATION STRESS AS ONE OF THE MOST IMPORTANT FACTORS OF AN ACUTE ENDOTHELIAL DAMAGE

Abstract

The aim of the work was to study the dynamics of circulating endothelial cells in peripheral blood and to determine the role of free radical oxidation processes in damage to endothelial cells. On the basis of the conducted research – to improve the treatment of patients with influenza A.

On the basis of a survey of 158 patients with influenza A, of whom 32 patients were with mild, 62 patients – with moderate severity and 64 patients – with severe influenza at the age of 18 to 45 years, there was a correlation between the increase in the level circulating endothelial cells and the activity of free radical oxidation processes, the effectiveness of complex treatment in patients with influenza A was shown. Based on the performed studies, it was found that excessive increase in the activity of lipid peroxidation processes with a decrease in the level of antioxidant defense plays an important role in the pathogenesis of the influenza. A direct relationship was established between the degree of concentration of malonic dialdehyde, the new conjugate and ketodynes in the blood of patients with influenza with severe course of the disease. In the study of circulating endothelial cells in patients with influenza, an increase in their total number was found, depending on the severity of the disease. The enhanced detachment of endothelial cells from the basement membrane in the study groups is evidence of the combined action of influenza toxins and cytotoxic products of free radical oxidation. 2-ethyl-6-methyl-3-hydroxypyridine succinate was added to the baseline therapy in order to reduce the toxic effect of lipid peroxidation products in 32 patients with moderately severe disease, whose mechanism of action was due to its antioxidant and membrane-protective effects. The conducted studies allowed the following conclusions: the imbalance in the system of LPO/AOD leads to depression and depletion of the antioxidant system, damage to endothelial cells with the further development of endothelium dysfunction; an increase in the total number of circulating endothelial cells in the blood develops in response to oxidative stress; An integrated approach to the treatment of influenza with the administration of drugs with an antiradical mechanism of action has a beneficial effect on the flu and reduces the manifestations of vascular endothelial damage.