KLEBSIELLA PNEUMONIAE – THE LEADING CAUSE OF WOUND INFECTION
DOI:
https://doi.org/10.11603/1681-2727.2025.2.15299Keywords:
K. pneumoniae strains, antibiotic sensitivity, wound infection, mine-explosive injuriesAbstract
SUMMARY. The aim of the work is to determine the microbiome of wound infection, to study the sensitivity of clinical isolates of K. pneumoniae to the action of antibacterial drugs of different groups.
Patients and methods. The study involved 96 patients with wound infection resulting from mine-explosive injuries (men aged 20 to 45 years). The main selection criteria were the patient’s status as a military serviceman, the fact that the patient had received a mine-explosive injury in combat conditions, the presence of the results of a microbiological examination of the wound, which was considered a sign of the presence of an infectious process or suspicion of it. The analysis of the microbiome of wound infection was carried out by the bacteriological method of research. Determination of sensitivity to antibiotics was done by the disk-diffusion method.
Research results and their discussion. 46 strains were isolated from wound contents of patients, among which in 39.0 % of cases the leading etiological factor of wound infection was K. pneumoniae, in 28.0 % – S. aureus, P. aeruginosa (13.0 %), Acinetobacter spp (8.7 %) and the specific weight of isolated strains of E. faecalis and E. coli was (4.3 %) and (6.5 %), respectively. The highest antibiotic resistance to different classes of antibacterial drugs was observed in half of isolated cultures of K. pneumoniae, among which polyresistant strains prevailed.
Conclusions. Analysis of the level of antibiotic sensitivity of isolated clinical strains of K. pneumoniae demonstrated low rates. The most sensitive strains of K. pneumoniae were found to amikacin and gentamicin (45.4 %), sensitivity to piperacillin/tazobactam was 36.3 %, and the number of strains sensitive to ceftazidime, meropenem, levofloxacin and ciprofloxacin was 27.2 %. The antibiotics amoxicillin, ampicillin, ceftriaxone, cefepime, cefoperazone, cefepime, cefotaxime, imepenem had less activity, the sensitivity to which was almost 9 %.
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