DETERMINATION OF CLINICAL EFFECTIVENESS OF INNOVATIVE DRUGS IN PATIENTS WITH WOUND DEFECTS

Abstract

The aim of the work: determine the clinical efficacy of the proposed treatment regimen in patients with complicated wounds, using granulation rate, epithelialization speed, and functional activity of innate immune cells as endpoints, compared with standard therapy.

Materials and Methods. A prospective cohort study included 11 patients with chronic complicated wounds. Patients from the main group received a two-component wound treatment regimen using two drugs: spray (decamethoxin, hydrolyzed collagen, glycine, arginine, aspartic acid) and gel (collagen, sodium hyaluronate, silver sulfadiazine, decamethoxin, silicon dioxide). Patients from the comparison group received a standard treatment regimen, which included surgical wound debridement, antiseptic treatment, systemic antibiotic therapy (penicillins, cephalosporins, fluoroquinolones, metronidazole, lincosamides, carbapenems, monobactams) and local antiseptics with propylene glycol. The dynamics of regenerative processes was assessed by cytological analysis of the wound surface. The quantitative ratio of cellular elements was determined, which allowed assessing the degree of inflammatory reaction and the level of tissue regeneration. Statistical data processing was performed using licensed software IBM SPSS Statistics, version 26.0 (license No. ABCD-123456; IBM Corp., Armonk, NY, USA).

Results. Patient selection was carried out in accordance with the specified inclusion and exclusion criteria. The study involved people aged 18–80 years who had unhealed complicated wounds lasting more than 3 months. At the initial stage (5th day), the area of ​​granulations in the main group reached 45 %, which is 20 % more than in the comparative group (p<0.05). By the 20th day, complete epithelialization was observed in 81.8 % of patients in the main group versus 40 % in the comparative group (p<0.05). The results of cellular analysis showed a decrease in degenerative neutrophils by 1.77 times (p<0.05) and an increase in monocytes with lymphocytes. Phagocytosis activity increased: HCT-positive neutrophils increased by 2.18 times, myeloperoxidase – by 1.38 times (both p<0.05).

Conclusions. The proposed regimen accelerates granulation tissue formation and epithelialization, optimizes the inflammatory response, and sustains immune activation, thereby shortening healing times compared with standard therapy.